6. • Denaturation of intracellular proteins.
• Enzymatic digestion of the cell.
PATHOGENESIS OF NECROSIS
7. MORPHOLOGY
• Increased eosinophilia of cytoplasm
• Glassy homogeneous appearance
• Cytoplasm is vacuolated
• Calcification of dead cells.
• Appearance of myelin figures
10. COAGULATIVE NECROSIS
• Preservation of general tissue architecture
• Affected tissue is firm
• Denaturation of structural proteins and enzymatic digestion of
cells.
• Example – Heart, kidney,spleen.
11.
12. • The tissue becomes liquid
viscous mass
• Material is creamy yellow
in color
• Seen in brain, abscess.
LIQUEFACTIVE NECROSIS
13.
14. WET GANGRENE
• In moist tissue like mouth,
bowel, lung, cervix
• Diabetic foot
• Bed sores
15. • In moist tissues like mouth, bowel, lung, cervix
• D
i
a
b
e
t
i
c
WET GANGRENE INTESTINE
16. DRY GANGRENE
• Toes and feet due to arteriosclerosis
• Thromboangitis obliterans
• Raynaud disease Trauma
18. • Wet gangrene caused by
gram positive anaerobic
bacteria
• Seen in muscle and in
colon
19. • Type of coagulative
necrosis
• Seen in tuberculous
infections
• Tissue is cheesy white in appearance
• The tissue architecture is preserved
CASEOUS NECROSIS
20. • Seen in pancreas, breast
• Grossly visible
chalky white areas.
• Presence of shadowy
outlines of necrotic cells.
FAT NECROSIS
