Introduction to Pharmacology- Definition, scope and source of drugs, dosage form and routes of drug administration. Pharmacodynamics-Mechanism of drug action, Receptors, classification and drug receptors interaction, combined effect of drugs, factors modifying drug action. Pharmacokinetics-Mechanism and principle of Absorption, Distribution, Metabolism and Excretion of drugs. Principles of basic and clinical pharmacokinetics. Pharmacogenetics. Adverse drug reactions. Discovery and development of new drugs-Preclinical and clinical studies. mcqs gpat niper di

1. GPAT-MCQS-SERIES
PART-1
BASIC PHARMACOLOGY
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SYLLABUS: Introduction to Pharmacology- Definition, scope and source of drugs, dosage form
and routes of drug administration. Pharmacodynamics-Mechanism of drug action, Receptors,
classification and drug receptors interaction, combined effect of drugs, factors modifying drug
action. Pharmacokinetics-Mechanism and principle of Absorption, Distribution, Metabolism and
Excretion of drugs. Principles of basic and clinical pharmacokinetics. Pharmacogenetics.
Adverse drug reactions. Discovery and development of new drugs-Preclinical and clinical
studies.
1. Following statements are true:
[P] An epidermic means simple application of medicament on the skin
[Q] An epidermic means application of medicament by rubbing
[R] Iontophoresis means application of medicament to and pushing it through skin to reach the
blood vessels by electric transmission
[S] Inunction means simple application of medicament on the skin
(a) P and Q
(b) Q and R
(c) Q and S
(d) P and R
2. Following statements are true for intradermal route:
[P] The drug is injected under skin
[Q] This route is used for testing sensitivity to drug like penicillin
[R] The drug is given within the skin layer
[S] Special process of infusing large amount of drugs like glucose
(a) P and R (b) Q and R
(c) Q and S (d) P and S
3. MgSO4 exerts their various effects through following route are true:
[P] It produces purgative effect if given orally
[Q] It produces depressant effect if given parenterally
[R] It does not produce any effect if given parenterally
[S] It increases intracranial tension if given enema
(a) P and Q (b) R and S
(c) Q and S (d) P and S

2. 4. Following statements are true for passive diffusion:
[P] It is saturable
[Q] It is nonselective
[R] It is energy dependent
[S] It is energy independent
(a) P and R (b) Q and R
(c) Q and S (d) P and S
5. Following statement are true for facilitated diffusion:
[P] It is unsaturable
[Q] It is Non selective
[R] It is energy dependent
[S] It is energy independent
(a) P and R (b) Q and R
(c) Q and S (d) P and S
6. Transport diffusion is proportional to concentration
gradient in
[P] Active transport
[Q] Facilitated diffusion
[R] Passive diffusion
[S] Ion pair transport
(a) P and R (b) Q and R
(c) Q and S (d) R and S
7. Following drug have more than 99% protein-binding
capacity
[P] Digoxin [Q] Aspirin
[R] Thyroxine [S] Warfarin
(a) P and Q (b) P and R
(c) Q and S (d) R and S
8. Following drug have less than 50% protein-binding capacity
[P] Insulin
[Q] Aminoglycoside antibiotic
[R] Diazepam
[S] Aspirin
(a) P and Q (b) Q and R
(c) Q and S (d) P and S
9. Spironolactone is a prodrug and its active metabolite is
(a) Desmethyl spironolactone
(b) Canrencne
(c) Acetylspironolactone
(d) None of the above

3. 10. Most of the drug is absorbed through
(a) Active transport
(b) Facilitated diffusion
(c) Passive diffusion
(d) Ion pair transport
11. Morphine’s affects the eye by:
(a) Producing miosis through an action on the oculomotor nerve
(b) Producing mydriasis through an action on the sympathetic system
(c) Decreasing pupillary responses to light
(d) Directly acting on the smooth muscles of the iris
12. pD2 value means
(a) Negative log of molar concentration of an antagonist which produces half of the maximum
response
(b) Negative log of molar concentration of an antagonist which produces of the maximum
response
(c) Negative log of molar concentration of an agonist which produces of the maximum response
(d) Negative log of molar concentration of an agonist which produces half of the maximum
response
13. Drug having high affinity but low intrinsic activity is called
(a) Partial agonist
(b) Antagonist
(c) Non-competitive antagonism
(d) Competitive antagonism
14. Phentolamine is competitive antagonism of
(a) Acetylcholine (b) Isoprenaline
(c) Noradrenaline (d) Atropine
15. pA2 can be defined as
(a) Negative log of molar concentration of an antagonist which produces half of the maximum
response
(b) Negative log of molar concentration of an agonist which produces half of the maximum
response
(c) Negative log of molar concentration of an antagonist in the presence of which double dose of
agonist required to produce same effect as produced in absence of antagonist
(d) Negative log of molar concentration of an antagonist in the presence of which half dose of
agonist required to produce same effect as produced in absence of
Antagonist
16. Following are the chloride channel blocker
[P] Amiloride [Q] Cadmium
[R] Picrotoxin [S] Ketamine

4. (a) R and S (b) Q and R
(c) Q and S (d) P and S
17. Following statements are true
[P] Synergism means if two or more drugs are taken simultaneously they increase the potency
and/or duration of other drug
[Q] Addition means in which total effect of two drugs is just equal to the sum of their individual
effects
[R] Potentiation means one drug produces own effect and increases the effect of other drug
[S] Synergism means one drug does not produce any effect but increases the effect of other drug
(a) P and Q (b) Q and R
(c) Q and S (d) P and S
18. Acetylcholine and physostigmine are examples of ______ type drug interaction.
(a) Synergism (b) Addition
(c) Potentiation (d) Antagonism
19. In the bioassay the convulsion activity in mice is
observed during _____ use.
(a) Insulin (b) Histamine
(c) Prolactin (d) Oxytocin
20. Following drugs have volume of distribution more
than 200:
[P] Warfarin [Q] Amitryptyline
[R] Digoxin [S] Alcohol
(a) P and Q (b) Q and R
(c) Q and S (d) P and S
21. Isolated rabbit jejunum is used
(a) To check adrenergic activity and mechanism
(b) To check the activity of skeletal muscle
(c) To check the activity straight muscle
(d) None of the above
22. Bioassays are carried out to:
(a) Measure the pharmacological activity of a drug
(b) Avoid clinical trials for new drugs
(c) Detect the impurity in a given drug
(d) Screen from pharmacogenetic influences of new drugs
23. Which of the following is CYP450 enzyme inhibitor?
(a) Grape juice (b) Rifampicin
(c) Barbiturates (d) Carbamazepine
24. Which of the following receptor shows the slowest response?

5. (a) GPCR (b) Ion channel
(c) Enzyme linked (d) Steroid receptor
25. Most common Phase-II reaction is
(a) Sulfate conjugation:
(b) Glucuronide conjugation
(c) α amino acid conjugation
(d) Methylation
Answer Keys
1. (d) 2. (b) 3. (a) 4. (c) 5. (c) 6. (b) 7. (d) 8. (a) 9. (b) 10. (c)
11. (c) 12. (d) 13. (a) 14. (c) 15. (c) 16. (a) 17. (a) 18. (c) 19. (a) 20. (b)
21. (a) 22. (a) 23. (a) 24. (d) 25. (b)