Membrane proteomics

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Cell membrane proteins perform important functions such as exchange of materials and out of the cell, cell recognition and immune response, signal transduction and regulation, and energy transfer. To better understand their functiond, it is necessary to reveal the characteristics of membrane proteins and monitor the modification and regulation of their expression. https://www.creative-proteomics.com/services/metabolomics-service.htm

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Edman Degradation is one of the N-terminal amino acid sequence analysis methods for peptide chains/proteins sequencing. The protein is reacted with PTC under weakly basic conditions and then treated with an acid to free the amino-terminal residue of the peptide chain in the form of PTH-AA for subsequent analysis. Peptide Mapping analysis is an effective method for rapidly localizing protein sequences and is a commonly used strategy in protein identification. The method uses mass spectrometry for peptide analysis and compares the obtained spectra with a protein database to obtain amino acid information. De Novo Protein Sequencing is a method based on the enzymatically cleaved peptides that exhibit regular fragmentation in mass spectrometry to obtain amino acid information from the mass differences in regular mass spectral peaks. https://www.creative-proteomics.com/services/proteomics-service.htm

Methods for Protein Sequencing.pdf

Methods for Protein Sequencing.pdf

Methods for Protein Sequencing.pdf

Creative Proteomics

Untargeted metabolomics is mainly conducted to comprehensively understand biochemical information metabolism in organisms. Using liquid chromatography-mass spectrometry technology, almost all metabolites under certain physiological or other specific conditions can be qualitatively and quantitatively analyzed for the identification of different metabolites. https://metabolomics.creative-proteomics.com/untargeted-metabolomics-service.htm

Introduction to Untargeted Metabolomics.pdf

Introduction to Untargeted Metabolomics.pdf

Introduction to Untargeted Metabolomics.pdf

Creative Proteomics

A chiral substance can rotate its polarization plan when plane-polarized light passes through it. This phenomenon is called "optical rotation." Here is the reason for the optical rotation: when the left-handed light and the right-handed light that make up the plane polarized light propagate through a chiral material, their refractive indices are different (nR≠nL). Therefore, the propagation speed of the circularly polarized light in the two directions in the chira material is different (vR≠vL), which leads to the rotation of the polarization plane. https://www.creative-proteomics.com/pronalyse/the-principle-of-circular-dichroism.html

Electronic circular dichroism(ECD).pdf

Electronic circular dichroism(ECD).pdf

Electronic circular dichroism(ECD).pdf

Creative Proteomics

Edman Degradation is one of the N-terminal amino acid sequence analysis methods for peptide chains/proteins sequencing. The protein is reacted with PTC under weakly basic conditions and then treated with an acid to free the amino-terminal residue of the peptide chain in the form of PTH-AA for subsequent analysis. Peptide Mapping analysis is an effective method for rapidly localizing protein sequences and is a commonly used strategy in protein identification. The method uses mass spectrometry for peptide analysis and compares the obtained spectra with a protein database to obtain amino acid information. De Novo Protein Sequencing is a method based on the enzymatically cleaved peptides that exhibit regular fragmentation in mass spectrometry to obtain amino acid information from the mass differences in regular mass spectral peaks. https://www.creative-proteomics.com/services/proteomics-service.htm

Three Methods for Protein Sequencing

Three Methods for Protein Sequencing

Three Methods for Protein Sequencing

Creative Proteomics

Targeted and Discovery Proteomics

Targeted and Discovery Proteomics

Targeted and Discovery Proteomics

Creative Proteomics

Protein qualitative analysis based on mass spectrometry explores protein expression within organisms. Mass spectrometry offers highly efficient, robust, and accurate results and is one of the core technologies for proteomic research. Protein identification is a common topic for biochemistry research, and mass spectrometry is considered one of the most useful techniques that solve this issue. Two major strategies that are widely used for protein identification by mass spectrometry are MALDI-TOF-based protein fingerprinting and LC-MS/MS-based peptide sequencing. Meanwhile, LC-MS/MS reserved higher sensitivity and ability than MALDl-TOF and can accurately identify multiple protein components from a single sample. https://www.creative-proteomics.com/services/protein-identification.htm

Protein Qualitative Analysis Services

Protein Qualitative Analysis Services

Protein Qualitative Analysis Services

Creative Proteomics

Untargeted metabolomics is mainly conducted to comprehensively understand biochemical information of metabolism in organisms. Using liquid chromatography-mass spectrometry technology(LC-MS), almost all metabolites under certain physiological or other specific conditions can be qualitatively and quantitatively analyzed for the identification of different metabolites. To the greatest extent, untargeted metabolomics reflects the multiple dynamic responses of living organisms to external stimuli, pathophysiological changes, and gene mutations in metabolite levels in vivo, offering a new perspective for disease diagnosis, pathological research, new drug development, drug toxicology, and other studies. https://metabolomics.creative-proteomics.com/untargeted-metabolomics-service.htm

Why Choose Untargeted Metabolomics

Why Choose Untargeted Metabolomics

Why Choose Untargeted Metabolomics

Creative Proteomics

Untargeted metabolomics is mainly conducted to comprehensively understand biochemical information of metabolism in organisms. Using liquid chromatography-mass spectrometry technology, almost all metabolites under certain physiological or other specific conditions can be qualitatively and quantitatively analyzed for the identification of different metabolites. https://www.creative-proteomics.com/services/untargeted-metabolomics.htm

Untargeted Metabolomics Solutions

Untargeted Metabolomics Solutions

Untargeted Metabolomics Solutions

Creative Proteomics

Untargeted metabolomics is mainly conducted to comprehensively understand biochemical information of metabolism in organisms. Using liquid chromatography-mass spectrometry technology, almost all metabolites under certain physiological or other specific conditions can be qualitatively and quantitatively analyzed for the identification of different metabolites. https://www.creative-proteomics.com/services/untargeted-metabolomics.htm

Untargeted Metabolomics Solutions

Untargeted Metabolomics Solutions

Untargeted Metabolomics Solutions

Creative Proteomics

Metabolomics is a study of a complete set of metabolites in a specific cell or organism. Metabolomics analysis aims at simultaneous identification and quantitative analysis of intracellular metabolites. Since metabolomics is focused on a whole set of metabolites, it reflects the metabolomics activity of the organism, and hence, allows researchers to explore the biological system. An Accurate study on metabolomics relies on sensitive and sophisticated analytic platforms and bioinformatics analysis systems. With years of developing and refining our bioinformatics analysis system, Creative Proteomics offers comprehensive bioinformatics support to our clients’ research! https://www.creative-proteomics.com/services/bioinformatic-analysis-for-metabolomics-study.htm

Bioinformatics Analysis of Metabolomics Data

Bioinformatics Analysis of Metabolomics Data

Bioinformatics Analysis of Metabolomics Data

Creative Proteomics

Proteins play a key role in molecular recognition and are at the core of all biological processes. They can interact with other components of the cell, such as small molecular metabolites, nucleic acids, membranes and other proteins to build supramolecular components and carefully design molecular machines that perform various functions, from chemical catalysis, mechanical work to signal transmission And adjustment. So far, large-scale protein-protein interactions have been identified, and all the generated data is collected in a special database, which can create large-scale protein interaction networks. Like metabolism or genetic/epigenetic networks, the study of PPIs can help us understand the mechanisms of signal transduction, transmembrane transport, cell metabolism and other biological processes through stable or transient, covalent or non-covalent interactions. https://www.creative-proteomics.com/services/protein-protein-interaction-networks.htm

Protein Network Analysis

Protein Network Analysis

Protein Network Analysis

Creative Proteomics

Untargeted metabolomics is mainly conducted to comprehensively understand biochemical information of metabolism in organisms. Using liquid chromatography-mass spectrometry technology, almost all metabolites under certain physiological or other specific conditions can be qualitatively and quantitatively analyzed for the identification of different metabolites. https://www.creative-proteomics.com/services/untargeted-metabolomics.htm

Why Choose Untargeted Metabolomics

Why Choose Untargeted Metabolomics

Why Choose Untargeted Metabolomics

Creative Proteomics

Proteomics is a discipline that analyzes the dynamics of protein components, including expression levels and modification states from a holistic perspective, understands the interactions and connections between proteins, reveals the function of proteins and the laws of cell life, and studies all proteins in cells and their behaviours. Creative Proteomics can provide a comprehensive range of proteomics services to help you better conduct research in the drug discovery process, which includes: protein gel and imaging analysis, protein identification, protein quantification, top-down proteomics, peptidomics, post-translational modification analysis, and protein-protein interaction. https://www.creative-proteomics.com/services/protein-gel-and-imaging-analysis.htm

Proteomics, A Major New Technology for Drug Discovery

Proteomics, A Major New Technology for Drug Discovery

Proteomics, A Major New Technology for Drug Discovery

Creative Proteomics

Untargeted metabolomics is mainly conducted to comprehensively understand biochemical information metabolism in organisms. Using liquid chromatography-mass spectrometry technology, almost all metabolites under certain physiological or other specific conditions can be qualitatively and quantitatively analyzed for the identification of different metabolites. https://metabolomics.creative-proteomics.com/untargeted-metabolomics-service.htm

Untargeted Metabolomics

Untargeted Metabolomics

Untargeted Metabolomics

Creative Proteomics

Proteomics is a discipline that analyzes the dynamics of protein components, including expression levels and modification states from a holistic perspective, understands the interactions and connections between proteins, reveals the function of proteins and the laws of cell life, and studies all proteins in cells and their behaviours. Creative Proteomics can provide a comprehensive range of proteomics services to help you better conduct research in the drug discovery process, which includes: protein gel and imaging analysis, protein identification, protein quantification, top-down proteomics, peptidomics, post-translational modification analysis, and protein-protein interaction. https://www.creative-proteomics.com/services/protein-gel-and-imaging-analysis.htm

Proteomics and pharmacoproteomics

Proteomics and pharmacoproteomics

Proteomics and pharmacoproteomics

Creative Proteomics

Microorganisms such as bacteria, actinomycetes, and fungi are ubiquitous on our planet. They are widely distributed in soil, water, the human body and other environments. Microorganisms and their activities are of great importance to biogeochemical cycles and to all biological systems. Creative Proteomics provides a one-stop proteomics service from sample collection, protein separation, to protein quantification and bioinformatics analysis. We offer both relative quantification (including iTRAQ, TMT and SILAC) and absolute quantification (such as SRM/MRM and PRM) approaches to help you discover, detect and quantify proteins in a broad array of samples. https://www.creative-proteomics.com/services/proteomics-service.htm

Importance of microbial research

Importance of microbial research

Importance of microbial research

Creative Proteomics

Flow Cytometry (FC) determines multiple physical and biological characteristics of cells by detecting the intensity of the scattered or emitted light of a single cell in a linear flow state before laser irradiation. This technology can analyze cells rapidly at a rate of tens of thousands of cells per second. The types of samples can be various types of cells (such as peripheral blood, bone marrow, solid tissues, cells in suspension or adherent culture), microorganisms, synthetic microspheres, etc. https://www.creative-proteomics.com/services/flow-cytometry-facs-service.htm

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Flow cytometry and fluorescence microscopy

Flow cytometry and fluorescence microscopy

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Proteomics is a discipline that analyzes the dynamics of protein components, including expression levels and modification states from a holistic perspective, understands the interactions and connections between proteins, reveals the function of proteins and the laws of cell life, and studies all proteins in cells and their behaviours. Creative Proteomics can provide a comprehensive range of proteomics services to help you better conduct research in the drug discovery process, which include: protein gel and imaging analysis, protein identification, protein quantification, top-down proteomics, peptidomics, post-translational modification analysis, and protein-protein interaction. https://www.creative-proteomics.com/services/protein-gel-and-imaging-analysis.htm

Proteomics accelerates the drug discovery process

Proteomics accelerates the drug discovery process

Proteomics accelerates the drug discovery process

Creative Proteomics

Microorganisms such as bacteria, actinomycetes, and fungi are ubiquitous on our planet. They are widely distributed in soil, water, the human body and other environments. Microorganisms and their activities are of great importance to biogeochemical cycles and to all biological systems. Creative Proteomics provides a one-stop proteomics service from sample collection, protein separation, to protein quantification and bioinformatics analysis. We offer both relative quantification (including iTRAQ, TMT and SILAC) and absolute quantification (such as SRM/MRM and PRM) approaches to help you discover, detect and quantify proteins in a broad array of samples. https://www.creative-proteomics.com/services/proteomics-service.htm

Proteomics contributes to your microbial research

Proteomics contributes to your microbial research

Proteomics contributes to your microbial research

Creative Proteomics

Untargeted metabolomics is mainly conducted to comprehensively understand biochemical information of metabolism in organisms. Using liquid chromatography-mass spectrometry technology, almost all metabolites under certain physiological or other specific conditions can be qualitatively and quantitatively analyzed for the identification of different metabolites. https://www.creative-proteomics.com/services/untargeted-metabolomics.htm

Why choose untargeted metabolomics solutions

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www.seribangash.com The Mariana Trench is one of the most remarkable geological features on Earth. Here are some details about it: Location: The Mariana Trench is located in the western Pacific Ocean, east of the Mariana Islands. It stretches for about 2,550 kilometers (1,580 miles) and is known as the deepest part of the world's oceans. Depth: The trench reaches incredible depths, with its deepest point known as the Challenger Deep, which plunges down to approximately 10,984 meters (36,037 feet) below sea level. To put this into perspective, if Mount Everest, the tallest mountain on Earth, were placed at the bottom of the Challenger Deep, its peak would still be over 2 kilometers (1.25 miles) underwater. Formation: The Mariana Trench was formed by the subduction of the Pacific Plate beneath the Mariana Plate. This process creates a deep trench as the heavier Pacific Plate is forced beneath the lighter Mariana Plate. Geological Features: The trench is characterized by steep, V-shaped valleys, and its walls are composed of highly compressed sedimentary rock. At the bottom of the trench, there are also large amounts of marine sediment. Pressure: The pressure at the bottom of the Mariana Trench is immense, reaching over 1,000 times the pressure at the surface. This extreme pressure creates a challenging environment for exploration and makes it difficult for organisms to survive. Exploration: Despite its extreme conditions, the Mariana Trench has been the subject of numerous scientific expeditions and explorations. One of the most famous explorations was the dive to the Challenger Deep by Swiss scientist Jacques Piccard and U.S. Navy Lieutenant Don Walsh in 1960. More recently, in 2012, filmmaker James Cameron made a solo dive to the bottom of the Challenger Deep in the Deepsea Challenger submersible. Biological Discoveries: Despite the harsh conditions, the Mariana Trench is home to a surprising variety of life forms, including unique species of deep-sea fish, crustaceans, and microbial life. Some organisms have adapted to survive in the extreme pressure and darkness of the trench. Environmental Importance: Studying the Mariana Trench provides valuable insights into the geology, biology, and oceanography of the deep sea. It also helps scientists better understand the processes that shape the Earth's crust and the distribution of life in the oceans. Conservation: Due to its remote location and extreme depths, the Mariana Trench has remained relatively untouched by human activity. However, there is growing concern about the potential impacts of deep-sea mining and pollution on this fragile ecosystem, highlighting the need for conservation efforts to protect this unique environment. https://seribangash.com/barber-shop-business-complete-guide-for-beginners/ https://seribangash.com/legend-virat-kohli-in-cricket-history/

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TheCarringtoneventof1859hasbeenthestrongestsolarflareintheobservationalhistory.ItplaysacrucialroleinsheddinglightonthefrequencyandimpactsofthepastandfutureSolarEnergeticParticle(SEP)eventsonhumansocieties.WeaddresstheimpactoftheCarringtoneventbymeasuringtree‐ring14Cwithmultiplereplicationsfromhigh‐latitudelocationsaroundtheeventandbycomparingthemwithmid‐latitudemeasurements.Atransientoffsetin14Cfollowingtheeventisobservedwithhighstatisticalsignificance.Ourstate‐of‐the‐art14Cproductionandtransportmodeldoesnotreproducetheobservationalfinding,suggestingfeaturesbeyondpresentunderstanding.Particularly,ourobservationwouldrequirepartiallyfasttransportof14Cbetweenthestratosphereandtroposphereathighlatitudes.TheobservationisconsistentwiththepreviousfindingswiththeSEPeventsof774and993CEforwhichfasterintegrationof14Cintotreeringsisobservedathighlatitudes

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Ultrasound color Doppler imaging has been routinely used for the diagnosis of cardiovascular diseases, enabling real-time flow visualization through the Doppler effect. Yet, its inability to provide true flow velocity vectors due to its one-dimensional detection limits its efficacy. To overcome this limitation, various VFI schemes, including multi-angle beams, speckle tracking, and transverse oscillation, have been explored, with some already available commercially. However, many of these methods still rely on autocorrelation, which poses inherent issues such as underestimation, aliasing, and the need for large ensemble sizes. Conversely, speckle-tracking-based VFI enables lateral velocity estimation but suffers from significantly lower accuracy compared to axial velocity measurements. To address these challenges, we have presented a speckle-tracking-based VFI approach utilizing multi-angle ultrafast plane wave imaging. Our approach involves estimating axial velocity components projected onto individual steered plane waves, which are then combined to derive the velocity vector. Additionally, we've introduced a VFI visualization technique with high spatial and temporal resolutions capable of tracking flow particle trajectories. Simulation and flow phantom experiments demonstrate that the proposed VFI method outperforms both speckle-tracking-based VFI and autocorrelation VFI counterparts by at least a factor of three. Furthermore, in vivo measurements on carotid arteries using the Prodigy ultrasound scanner demonstrate the effectiveness of our approach compared to existing methods, providing a more robust imaging tool for hemodynamic studies. Learning objectives: - Understand fundamental limitations of color Doppler imaging. - Understand principles behind advanced vector flow imaging techniques. - Familiarize with the ultrasound speckle tracking technique and its implications in flow imaging. - Explore experiments conducted using multi-angle plane wave ultrafast imaging, specifically utilizing the pulse-sequence mode on a 128-channel ultrasound research platform.

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Membrane proteomics

1. Membrane Proteomics Solutions How to Analysis : © 2021 Creative Proteomics. All rights reserved. Contact Us