3. • Clinical immunology is the study of diseases
caused by disorders of the immune system (
failure malignant
growth of the cellular elements of the system
ets.).
• It
also involves diseases of other systems, where imm
7. Autoimmunity is the system of immune responses of an organism against its own cells and
tissues.
Autoimmune diseases arise from an abnormal
immune response of the body against substances and tissues normally present in the body (
autoimmunity). This may be restricted to certain organs (e.g. in autoimmune thyroiditis
) or involve a particular tissue in different places (e.g. Goodpasture's
disease which may affect the basement membrane in both the lung and the kidney).
8.
9. Gen
Hormone
Suppression of T-
cells
environmental factors
proliferation of В-
cells
Гиперактивность
плазматических
клеток
Ab rise
Against tissue
against the nucleus of
the cell
Ag-Ab in tissues
hyperactivation of the immune
system
Symptom - death
10.
11.
12.
13.
14. Oncology in the immune system
Lymphoid leukemias (also called lymphocytic,
lymphogenous, or lymphoblastic leukemias
) are a group of leukemias affecting circulating
lymphocytes, a type of white blood cells.
Such diseases are all lymphoproliferative disorders.
Most lymphoid leukemias involve a particular subtype
of lymphocytes, the B cells.
22. Primary immunodeficiency disorders:
examples and typical presentation
Primary immunodeficiencies are disorders in which part of the body's immune system is
missing or does not function normally. To be considered a primary immunodeficiency, the
cause of the immune deficiency must not be secondary in nature (i.e., caused by other
disease, drug treatment, or environmental exposure to toxins). Most primary
immunodeficiencies are genetic disorders; the majority are diagnosed in children under the
age of one, although milder forms may not be recognized until adulthood. About 1 in 500
people are born with a primary immunodeficiency.
