THIS IS PPT FOR PHARMACY STUDENT TO STUDY AND UNDERSTAND BASICS

2. It is also known as Hyperbilirubinaemia

3. Its is differenciate in to two types
 Post hepatic
 Hepatic
 Pre hepatic

4. The reason behind this
hyperbilirubinaemia
Increases the production of bilirubin
Decreases the uptake of bilirubin
Decreases the conjugation of bilirubin
Decreases excretion of bilirubin into bile

5. Two types of hyperbilirubinaemia
• Hyperbilirubinaemia
• (cholestasis)
Predominantly
conjugated
• Hyperbilirubinaemia
Predominantly
unconjugated

6. Predominantly conjugated
hyperbilirubinaemia
Extrahepatic OR
Obstructive
jaundice
Treatable by
surgery
Intrahepatic OR
Medical jaundice
It may go
worse by
surgery

7. Extrahepatic
 It is mechanically obstruction
 It seen in outside the liver bileduct
 Common causes are gallstone , carcinoma head of
pancreas,tumor of bileduct
It can be complete and sudden and partialy AND
incomplete

8. Intrahepatic
 Hereditary disorder
 Obstruction on biliary duct excretion are
characterized by ‘pure cholestasis’.
 It can be hepatocellular cholestasis causes by virus
hepatits and drugs are like chlorpromazine
,contraceptives