8. The developing neural tube is divided into 4 plates
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Roof plate: signaling center, Alar plate: sensory, Basal plate: motor, Floor plate:
signaling center
9. Shh & BMPs gradients in the vertebrate neural tube
9
Nature Reviews Neuroscience 5, 409-419 (May 2004)
10. Roles of Shh & BMPs signaling in neural development
10
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11. Dorsal-ventral axis in the neural tube
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Dorsal-ventral polarity in the neural tube is established by TGF-ß family, BMPs and
Sonic hedgehog (Shh).
Gilbert, S.F. (2000). Developmental Biology
12. BMP Family and Signaling Pathways
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Genes & Diseases. Volume 1, Issue 1, September 2014, Pages 87–105
13. Roles of Shh signaling in neural development
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http://dx.doi.org/10.3389/fncel.2013.00087
15. Sonic hedgehog (Shh) signaling
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Herzog, W. et al. (2003). Developmental Biology. 254. 1.
Shh interacts with two transmembrane proteins as it interacts with cells in the neural
tube.
16. Role of Shh and Ihh in the endodermal-mesodermal tissue
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Physiological Reviews Published 1 October 2007 Vol. 87 no. 4, 1343-1375
Three mammalian hedgehog genes, sonic hedgehog (Shh), indian hedgehog (Ihh),
and desert hedgehog (Dhh) have been identified.
18. Craniofacial Malformations in Fetal Alcohol Syndrome (FAS)
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Embryonic Development of Craniofacial Malformations in Fetal Alcohol Syndrome
(FAS)
Liz Shaw.Last modified February 21, 2011.
19. Sonic hedgehog in the mammalian tissue
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Western Blot: Sonic Hedgehog Antibody [NBP2-22139] - WB detection of Sonic
Hedgehog in A. human stomach, B. human fetal liver membrane, C. PC12 and D.
.fibroblast-like cell line derived from monkey kidney tissue
Support: 1-888-506-6887 | technical@novusbio.com
20. References
• The genetic and epigenetic journey of embryonic stem cells into mature neural
cells. Brendan M. Olynik, and Mojgan Rastegar. Front. Genet., 18 May 2012.
• En1 and Wnt signaling in midbrain dopaminergic neuronal development.
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• Glial specification in the vertebrate neural tube. David H. Rowitch. Nature
Reviews Neuroscience 5, 409-419 (May 2004)
• Gilbert, S.F. (2000). Developmental Biology (Sunderland, Massachusetts: Sinauer
Associates, Inc., Publishers).
• Herzog, W. et al. (2003). Adenohypophysis formation in the zebrafish and its
dependence on sonic hedgehog. Developmental Biology. 254. 1.
• BMP signaling in telencephalic neural cell specification and maturation.
Beatriz Gámez, Edgardo Rodriguez-Carballo and Francesc Ventura. Front. Cell.
Neurosci., 04 June 2013.
• Bone Morphogenetic Protein (BMP) signaling in development and human
diseases. Richard N. Wang, Jordan Green, Zhongliang Wang. Genes & Diseases.
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21. • Hedgehog Signaling in Development and Homeostasis of the Gastrointestinal
Tract. Gijs R. van den Brink. Physiological Reviews Published 1 October 2007 Vol.
87 no. 4, 1343-1375
• Transport of maternal cholesterol to the fetus is affected by maternal plasma
cholesterol concentrations in the Golden Syrian hamster. Katie T. Burke, Perry
L. Colvin, Leslie Myatt, et al. Manuscript received 19 October 2008 and in revised
form 11 December 2008 and in re-revised form 23 December 2008.
• Mechanisms of Alcohol-Induced Damage to the Developing Nervous System.
Charles R. Goodlett, Ph. D , and Kristin H. Horn
• Role of Sonic Hedgehog (Shh) in Alcohol-Induced Craniofacial Abnormalities.
by Erica O'Neil Keywords
• Fetal Alcohol Spectrum Disorder (FASD) Associated Neural Defects: Complex
Mechanisms and Potential Therapeutic Targets. Pooja Muralidharan ,
Swapnalee Sarmah , Feng C. Zhou and James A. Marrs. Brain Sci. 2013, 3(2),
964-991
• The pathogenesis of the clinical features of oral-facial-digital syndrome type I.
Wael M. AlKattan, MBBS, Mohammad M. Al-Qattan, MBBS, Sameer A. Bafaqeeh,
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