1. UNIVERSITY OF ŽILINA
DEPARTMENT OF ELECTROMAGNETIC AND
BIOMEDICAL ENGINEERING
TISSUE ENGINEERING IN
BIOMEDICINE
Michal Péteri
Filip Martiak

2. TISSUE ENGINEERING IN
BIOMEDICINE (HEALING & REPLACEMENT)
• Human body tissues
Connective tissue
Nervous tissue
Skeletal muscle
Cardiac muscle
Epithelilal tissue
Smooth muscle
Blood
• Beginnings of nanotechnology
 nanofibers
 Electrospinning
• Tissue engineering
 Cells and their use in tissue engineering
 Growing factors
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3. HUMAN BODY TISSUES
o Connective tissue
o Nervous tissue
o Skeletal muscle
o Cardiac muscle
o Epithelilal tissue
o Smooth muscle
o Bones 3

4. DIVISION OF EPITHELIAL TISSUE
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5. Blood
Blood elements
o Erythrocytes (Red blood
cells)
o Leukocytes (White blood
cells)
o Thrombocytes (Platelets )
Blood plasma
o Serum albumin
o Blood-clotting factors
o Immunoglobulines
o Lipoprotein particles
o Various of other proteins
o Various electrolytes
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6. BEGINNINGS OF NANOTECHNOLOGY
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Richard Phillips
Feynman
 put into the consciousness of the concept
of nanotechnology
 size of elements under 1µm
His idea: people will know and dominate the
nanoworld

7. NANOFIBERS AND ELECTROSPINNING
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8. TISSUE ENGINEERING
There are 3 basic components
• Cells
• Growing factors
• Relevant skeleton
Tissue engineering strategy...?
Isolation of healthy cells from the patient
Increasing of cells
Multiplication cells in vitro
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9. CELLS AND THEIR USE IN TISSUE
ENGINEERING
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Autologous cells Allogeneic cells

10. GROWING FACTORS
A growing factors is a naturally occurring substance
capable of stimulating cellular growth proliferation and
cellular differentiation.
 Usually it is a protein or a steroid hormone
 Growth factors typically act as signaling
molecules between cells
 Examples are cytokines and hormones that bind
to specific receptors on the surface of their target
cells.
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11. BIBLIOGRAPHY
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[1]http://www.slovenskachirurgia.sk/index.php?page=pdf_view&pdf_id=6025&maga
zine_id=17 [Online]. [Cit. 22 11 2013]
[2] Sodomka L.: Nanovlákna-struktura, vlastnosti, technológie, použití, Vlákna a
textil, 2006, vol. 13, no. 3, s. 78–86
[3] Yoshito Ikada : Challenges in tissue engineering, J. R. Soc. Interface, 22 October
2006, vol. 3, no. 10, s. 589-601
[4] X Ma: Biomimetic materials for tissue engineering, Advanced Drug Delivery
Reviews, Jan 2008, vol. 60, no. 2, s. 184-198

12. THANKS FOR YOUR ATTENTION