Gennaro D'Urso: PharmaDAO - The future of Medicine DAO Camp 2022 Website: https://daocamp.org Youtube: https://www.youtube.com/channel/UCeHtPZ_ZLZ-nHFMUCXY81RQ FB: https://www.facebook.com/DAO-Camp-102442798988862/

1. Optimizing the Discovery of Candidate Compounds

2. Founded in 2015
Generating the GeneScape™ Proprietary Database
Gene Response Matrix and
Modular Biology
Dr. Gennaro D’Urso Dr. Leland Hartwell Dr. Corey Nislow Dr. Guri Giaever
Drug Response Matrix and
Chemogenomic Profiling
The GN STORY

3. GeneScape™ QR Codes
Genotype Fitness

4. Gene-Level Analysis

5. GeneScape™ QR Map
Peroxisome
Metabolism and aa Biosynthesis
Secretion & Vesicle Transport
Protein Folding & Glycosylation
Cell Polarity & Morphogenesis
DNA Replication & Repair
Mitosis & Chr. Segregation
Nuclear Migration & Protein Degradation
Nuclear-Cytoplasmic Transport
Chromatin & Transcription
RNA Processing
Ribosome & Translation
Mitochondria
Source: Costanzo et al, 2010, Science

6. Bioactive Compound Positioning Source: Costanzo et al, 2010, Science

7. Discovery Case Study
One Compound was
Tested in Vivo and
Showed Decrease of
Viral PCR Signal
Identified a
Handful of
Compounds with
Matching QR-
DRMs
Two of these
Compounds
Subsequently Showed
nM COVID-19 Antiviral
Activity in Vitro
Value
1 2 3

8. Early Discovery/ Pre-Clinical Phase 1 Phase 2 Phase 3 FDA
5-7 Years 2 Years 2 Years 2 Years 1.5 Years
89.5 % Failure rate 55.5% Failure rate 80.4% Failure rate 68.8% Failure rate 28.7% Failure rate
Conventional Path (New Drug)
AI Chemistry Phase 1 EUA Phase 2 - 3
2 Years 2 Years 1 Years 1 Years
Accelerated Path (Start with Validated Target)
Phase 2 - 3
< 2 years (EUA)
GeneScape™
Discovery Options

9. Decentralizing Computers
“Personal computers are enriching what people do…
it is very decentralized, very democratic.”
Steve Jobs, 1981
9

10. Decentralizing the Human Genome
Human Genome Project
10

11. Decentralizing Pharmaceuticals
GeneScape™
11

12. PharmaDAO
Combining the Power of Gene1c Networks &
a Decentralized Autonomous Organiza1on (DAO)
12
DAO funds
candidate drugs $

13. Dr. Gennaro D’Urso
Founder, CEO Genetic Networks
Genetic Networks + PharmaDAO