Eye prophylaxis for retinal detachment (RD) is still a controversial issue since opinions are not unanimous regarding the kind of lesions to be treated or the method of treatment. This prospective clinical study aimed to follow the course of vitreoretinal conditions in 150 high risk fellow eyes.
4. Why to treat????
• Significant cause of reduced vision and blindness
• Incidence of RD 1 IN 10,000/yr(life expectancy)
• Surgery is the only treatment
• 98%of all RD are rhegmatogenous
• Inspite of successful reattachments Vn>20/50 in 50%of
cases
• Surgical failure rate -5-10% cases
Prophylaxis
5. • Gonin -breaks are the cause of
retinal detachment
• Prevention of RD-prophylactic
treatment of breaks or vitreoretinal
precursors of retinal breaks
• No adequate clinical trial to test
the value of preventive therapy
7. What to treat ???
• Predisposing factors
• High risk characteristics
• Other factors
Vitreous liquifaction
Absence of PVD
Type of break
Presence of VR traction
8. What to treat ???
• Predisposing factors
• High risk characteristics
• Other factors
9. Risk factors
• Vitreoretinal abnormalities
• Symptomatic patient
• Myopia
• Previous history of RD in other eye(12%)
• Family history
• Systemic disease-Sticklers syndrome,Marfans syndrome
• Intraocular procedures -Cataract extraction,YAG
capsulotomy
• Presence or absence of PVD
10. What to treat ???
• Predisposing factors
• High risk characteristics
• Other factors
Offensive lesion
LD
Snail track
Retinoschisis
VR pigment clumps
Cystic retinal tufts
WWOP
Benign lesion
Microcystoid
Honey comb
PSD
WWP
Drusens
13. Difference in predisposition
• Retinal breaks leading to RD can occur in locations other
than visible abnormal areas
• Diverse Retinal breaks-different prognosis
• Retinal tears with persistent VR traction-higher Risk of
RD
• > >
• >
Atrophic holesFlap HST operculated
holes
Symptomatic
breaks
Asymptomatic
breaks
14. Localised RD
• Localised RD-SRF more than 1 DD from the edge of the
break
• Subclinical RD-Anterior equator,no VF loss,<2DD of SRF
15. Why not treat all the VR lesions
• LD -8% of general population
• Present in 20-30%of retinal detachments
• LD leading to RD-0.3%-0.5%
• If all the LD are treated – overtreatment
• 1 in 10000/yr incidence of RD
• Presence of lesion = prophylaxis
Myopia, aphakia,
h/o RD in fellow eye
With LD
Normal eyes with LD
16. Whom to treat????
NOT TO TREAT TREAT
In evaluation of risk of RD
or natural history of retinal
breaks,or precursors of
retinal breakscases
should be categorised
with regards to presence
of high risk factors
20. Asymptomatic without HRC
LD:
• 8% of general population
• Present 20-30% RD
• LD rare cause of RD without HRC-
• Retinal breaks associated with LD =64% to 83% of
cases
• Tears along the posterior and lateral margin of LD
• Round atrophic holes-within LD-RD-young phakic
myopic eyes without PVD-1 IN 365 cases
• Prophylactic failure is reported-2.2%Tasman and
jaguers ,2.9%Boniuk etal
Incidence of retinal detachment after
prophylactic treatment may be no
different from the natural history of LD
No Treatment
21. Asymptomatic without HRC
• Cystic Retinal Tufts:
• Retinal breaks at time of PVD
• 10% of clinical RD
• Byer –Chance of RD in eyes with cystic
retinal tuft 1 in 357
No Treatment
22. Asymptomatic without HRC
Degenerative retinoschisis
• Splitting of retina at OPL or NFL
• RD occurs if there are holes in both the layers
• Previously outerlayer breaks –considered for prophylaxis
• Byer-natural history of retinoschisis-symptomatic retinal
detachment progression is rareNo Treatment
23. Asymptomatic without HRC
• Retinal breaks
• Autopsy studies
-break due to VR traction -3%
-break without VR traction-4%
• Clinical Studies
-14%-Rutnin and Schepens(102 pt)
-3.3%-Byer(3400 Eyes)
• No RD in 231eyes with asymptomatic breaks-Byer
• Neumann etal-asymptomatic retinal break:RD=218:1
- -
No Treatment
Asymptomatic retinal
breaks and
asymptomatic focal
RD due to round
holes within LD
low risk of
progression
RD
SLOW
24. Asymptomatic without HRC
Subclinical RD:
• First introduced by Schepens in 1952
• Jesberg,Okun ,Cibis
• Davis-1DD from the edge of the break and
not more than 2 DD posterior to equator
• Rarely progress to symptomatic RD-if
cause is hole within the LD
Round operculated Holes with SRF
around-rarely progress
Prominent pigmentary line-Observation
Flap tears with SRF-Likely to progress
Treatment
27. Asymptomatic Moderate and
high myopia
• Increased rate of vitreous liquifaction
• Increased rate of PVD
• Increased incidence of LD
• Increased risk of vitreous loss during surgery
• Among total RD 50% due to myopia
• Myopics –RD rate is 0.7%-6.6%(2%)
28. Precursor of retinal break and myopia
LD
• Karlin and Curtlin-11%eyes with AL >26.5% or more
• Cerolio and Pruett-
-41% of myopic eyes in AL 26-26.9mm
-7% of cases with AL >32 mm
• No data to determine –prophylaxis has benefit in-
Asymptomatic,phakic,
myopic,no family
history,no h/o of fellow
eye RD RD
29. Precursor of retinal break and myopia
• Cystic retinal tuft-no relation with refractive
error
• Retinal tears common with cystic retinal
tufts and myopia with PVD
• Retinoschisis not related to myopia
• Waldoff and Hagler-RD with retinoschisis
in myopes<RD with myopes.
Asymptomatic LD. Myopic,phakic
no family h/o or fellow eye RD
No Treatment
High Risk cases –prone to Pvd
Advised to report on onset of
symptoms(15%)
30. Retinal break and myopia
• Karlin and Curtin
• Neumann etal
AL % OF RETINAL
BREAK
<25 mm 3%
>25 mm 11%
AL HOLE:RD
MYOPIA 1:13.5
NONMYOPIC 1:218
Asymptomatic retinal break myopic ,
phakic no family h/o or fellow eye RD
No Treatment
High Risk cases –prone to
Pvd
Advised to report on onset of
symptoms(15%)
Flap Tears-TREAT
31. Subclinical detachment and
myopia
Asymptomatic,
phakic,myopic,
no h/o of RD in
fellow eye
RD
Asymptomatic Round operculated Holes with
SRF around-rarely progress
Prominent pigmentary line-Observation
Posterior extension-treatment
Flap tears with SRF-Likely to progress
Treatment
32. Asymptomatic aphakic and
pseudophakic
• Removal of crystalline lens-increased rates of retinal
tears
• Liquifaction of vitreous gel
• PVD occurs sooner
• 40%of RD occurs after cataract surgery
• Davis etal-183 eyes-asymptomatic retinal breaks in
aphakic eyes -50% RD
• Aphakia with myopia risk of RD is 2X
33. Aphakic and precursors of
retinal breaks
• Incidence of precursors of retinal breaks and in aphakia
is same as in general population
• Prevalence of LD in aphakic detachment decreases with
advancing age
• RD and retinal breaks less likely to be associated with
LD after cataract extraction in comparison with phakic
RD
Prophylactic treatment –
Not recommended for cystic retinal tufts
Not recommended for retinoschisis
Recommended preoperatiely for LD,no
PVD,young age
34. Aphakic/p’phakic and retinal
breaks
• Incidence of RD comparable with
asymptomatic phakic RD
• RD occur in sizeable number of cases
despite treatment
• Value of prophylactic therapy uncertain
• NO adequate data in patient –
aphakic,asymptomatic,no family history,or
fellow eye RD
Not recommended Retinal holes with old
age with PVD
Recommended for flap HST,no
PVD,young age(formation of new retinal
breaks at vitreous base not prevented)
Extensive treament-GRT in Fellow eye
Treatment
35. Aphakic/p’phakic and
subclinical RD
• No adequate data
• Decision of treatment-amount of SRF and type of retinal
break
Treatment
• Subclinical RD due to HST
• SRF approaches the equator
NoTreatment
• Subclinical RD due to atrophic holes within LD
37. Asymptomatic with familial
predisposition
• No adequate data for the prophylaxis
• Sticklers syndrome-hgh risk of RD
• Radial and perivascular lattices
• Poor prognosis post RD surgery
• Widespread treatment is required
• Prophylaxis in Radial and perivascular lattices-different
tractional forces-prophylaxis failure
• Treatment recommended-history of previous RD in
fellow eye
38. RD in fellow eye
• Pathological vitreous changes bilateral
• Incidence of RD in second eye 25%to 40%
• Symptomatic retinal tears with persistent vitreoretinal
traction-high risk of RD
• Prompt treatment
Benefits less convincing
• Precursors of retinal tears
• Asymptomatic breaks
• Symptomatic breaks without persistent VR traction
41. Asymptomatic with fellow eye
RD
• Precursors of retinal breaks in phakics
1. LD:
• LD in fellow eyes 9-34% cases
• Folk etal-6-15%of ld develop RD
• Folk etal-full treatment of LD had fewer retinal breaks
• Treatment not beneficial in high myope with LD>6 clock
hr
• Treatment
Cases with poor results post RD surgery with LD in
fellow eyes,mentally retarded patients
42. Asymptomatic with fellow eye
RD
• Precursors of retinal breaks in phakics
2.Cystic retinal tufts:
• cystic retinal tufts in RD=5%
• No data on prophylaxis
• No treatment
3.Degenerative retinoschisis:
No satisfactory evidence
Treatment
Localised areas of RD due to outer layer holes
43. Asymptomatic with fellow eye
RD
Retinal breaks in phakics
• Neumann etal-
Treatment :HST,Round holes without PVD,Subclinical
RD,Fellow eye of GRT
Round holes with operculum can be observed
AL RD:retinal break
Fellow eye RD 1:1.9
Myopic 1:13.5
NonMyopic 1:218
45. Asymptomatic with fellow eye
RD
• Precursors of retinal breaks in aphakics
1. LD:
LD in aphakic RD-25% to 34% of cases
Treatment recommende unless preexisting PVD
2.Cystic retinal tufts:treated the same way as LD
46. Asymptomatic with fellow eye
RD
Retinal breaks in aphakics
1. Flap tears-Treatment
2. Round holes with no PVD-Treatment
3. Round holes with PVD-Observe
4. Round holes with free operculum-Observe
Subclinical RD-
• Extensive RD as compared to phakics
• Scleral buckling
Prophylaxis recommended in fellow eye GRT
47.
48. Symptomatic without HRC
• Symptoms
• Acute contraction of vitreous gel
PVD
Traction on the retina
Photopsia,release of pigments-floaters
• 15% of symptomatic PVD –retinal tears
• Risk of RD more in presence of HRC
49. Precursor of retinal breaks
Retinal breaks
Subclinical detachment
Symptomatic eyes
No HRC
Symptomatic without HRC
50. Symptomatic Eyes with precursors of retinal
breaks
LD-with symptomatic PVD-flap tears in 66%
cases
Treatment recommended
After PVD with no HRC-Mere presence of LD not
an indication for prophylaxis
51. Symptomatic eye with retinal breaks
• Flap tears
• Retinal breaks with free operculum
• Atrophic holes
52. Symptomatic eye with retinal breaks
• Flap tears
• Retinal breaks with free operculum
• Atrophic holes
Persistent vitreous traction
Progress to RD in 33%to55%
Treatment reduces the risk 48% to 4%
53. Symptomatic eye with retinal breaks
• Flap tears
• Retinal breaks with free operculum
• Atrophic holes
Operculated break-traction released
Treatment not required
If traction persist –similar to HST
Treatment required
54. Symptomatic eye with retinal breaks
• Flap tears
• Retinal breaks with free operculum
• Atrophic holes
Within LD
RD seen in young myopic without PVD
Examined for signs of focal traction
Eyes with focal traction are treated
57. Whom to treat???
• Subclinical RD with flap tears
• Posterior extension of fluid
58. Whom to treat???
• Flap tears
• Preop, no PVD,young age
• Fellow eye GRT
• Fellow eye RD-Subclinical RD
• Poor VA post RD surgery
• MR
• Retinoschisis with OL holes
59. Whom to treat???
• Flap tears
• Persistent VR Traction
on the operculated holes
• Focal traction on round
atrophic holes
• Subclinical RD
69. Failure and complication
• RD inspite of prophylaxis
• Complication-treatment outcome worse than the natural
course of the disease
• ERM -1-2%
• Retinal breaks release pigment and limited PVR
71. Methods to avoid failure
• Medium intensity burns
• Away from the lesion
• Cover both anterior and posterior margins of the lesion
• Join the treatment area till ora in anterior lesion
Vr traction can be relieved with vitrectomy and scleral buckling ,prophylactic vitrectomy is ha
Asymptomatic retinal breaks and asymptomatic focal RD due to round holes within LD
low risk of progression
phakic nonmyopic eyes with no h/o RD in fellow eye
Flap tears with SRF-likely to progress-Prohylaxis
Not recommended Retinal holes with old age with PVD
Recommended for flap HST,no PVD,young age
Vr traction can be relieved with vitrectomy and scleral buckling ,prophylactic vitrectomy is ha