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Remote	Decision	Support	
with
Kevin	Shekleton
FHIR	DevDays 2017
November	16,	2017
The	problem	with	SMART	apps
Bilirubin	Chart
Newborns	<	120	hours	old
Bilirubin	results	that	are	either:
Not	documented
Outside	of	the	accepted	range
The	user	needs	to	know	the	app	is	available
The	user	needs	to	know	the	app	is	relevant
The	user	has	to	find the	app	and	launch	it
CDS	Hooks
A	vendor	agnostic	remote	decision	support	specification
Created	by	the	team	
behind	SMART
Open	source	(Apache) Emerging	standard	with	
active	development	and	
widespread	participation	
from	stakeholders
CDS	Service
A	service	that	is:
invoked	by	the	EHR	via	a	hook,
evaluates	its	own	logic	using	FHIR	data,
returns	decision	support	via	cards
Example	Hooks
patient-view
When	a	patient’s	chart	is	opened
medication-prescribe
When	a	medication	is	selected	for	prescription
order-review
Viewing	pending	orders	for	signing
CDS
Services
EHR	Med	Order
Toprol	XL
50	mg	daily
EHR	triggers	a	CDS	hook and	
invokes	a	remote	service
1
2
CDS	Service	executes
its	own	rules,	leveraging	
FHIR	data	as	needed
EHR
FHIR	Server
3
Returns	CDS	cards
(rendered	and	displayed	by	EHR)
$200	per	month
(patient	pays	$30)
Try	HCTZ	as	first-line
Switch	to	HCTZ
Managing	hypertension?
Launch	JNC	8	Rx	Pro
information card
suggestion card
smart	app	link	card
POST	https://example.com/cds-services/example-service
EHR CDS	Service
{
"hook": "patient-view”,
"fhirServer": "https://fhir.example.com",
"user": "Practitioner/789",
"patient": "123",
"encounter": "456",
...
}
EHR CDS	Service
POST	https://example.com/cds-services/example-service
CDS	
Service	
Logic
POST	https://example.com/cds-services/example-service
EHR CDS	Service
HTTP	1.1/	200	OK
{
"cards": [
{
"summary": "Example card",
"indicator": "info",
"source": {
"name": "Demo CDS Service”
}}]}
Cards
• A	CDS	Service	can	return	any	number	of	cards
• The	EHR	renders	each	card	as	it	sees	fit
• Each	card	must	have:
• A	concise	summary	(140	characters)
• An	indicator	noting	the	importance	of	the	card
• Information	on	the	organization	or	data	set	that	is	the	source	of	the	card’s	
data
CDS	Service	Response	JSON
{
"cards": [
{
"summary": "Example card",
"indicator": "info",
"source": {
"name": "Demo CDS Service”
}
}
]}
Card	Indicator
Informational Hard	StopWarning
Common	Card	Examples
Suggestions
Proposed	actions	encoded	as	FHIR	
resources
App	Links
Proposed	SMART	app	that	should	be	
used
Information	Only
Textual	information	for	the	provider
Cards	can	contain	any	combination	of	
information,	suggestions,	and	links
Capturing	user	behavior	for	analytics
• Since	CDS	Services	return	purely	JSON, they	don’t	know	how	users	
interact	with	their	suggestion
• Each	suggestion	may contain	a	UUID	
• The	UUID	allows	the	EHR	to	notify	the	CDS	Service	that	the	user	
interacted	with	their	suggestion
POST {cds-service}/analytics/{uuid}
CDS
Services
CDS
Service	
Provider
Base	https://example.com
Discovery /cds-services
Service /cds-services/{id}
Discovery
{
"services": [
{
"hook": "patient-view",
"name": "CDS Service Example",
"description": "An example CDS service",
"id": "example-service",
"prefetch": {
"patientToGreet": "Patient/{{Patient.id}}"
}
},
{...}
}
GET https://example.com/cds-services
CDS	Service	Invocation
{
"services": [
{
"hook": "patient-view",
"name": "CDS Service Example",
"description": "An example CDS service",
"id": "example-service",
"prefetch": {
"patientToGreet": "Patient/{{Patient.id}}"
}
},
{...}
}
POST https://example.com/cds-services/example-service
Security
EHR	provides	FHIR	access	token	to	CDS	Service
CDS	Service	trusts	the	EHR	via	signed	JWT
EHR	trusts	the	CDS	Service	via	its	TLS	endpoint
Security	>	JWT
{
"iss": "https://ehr.example.com/",
"aud": "https://example.org/cds-services/my-service",
"exp": 1422568860,
"iat": 1311280970,
"jti": "ee22b021-e1b7-4611-ba5b-8eec6a33ac1e”
}
eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.eyJpc3MiOiJodHRwczovL2ZoaXItZWhyLmV4YW1wbGUuY29tLyIsI
mF1ZCI6Imh0dHBzOi8vY2RzLmV4YW1wbGUub3JnL2Nkcy1zZXJ2aWNlcy9zb21lLXNlcnZpY2UiLCJleHAiOjE
0MjI1Njg4NjAsImlhdCI6MTMxMTI4MDk3MCwianRpIjoiZWUyMmIwMjEtZTFiNy00NjExLWJhNWItOGVlYzZ
hMzNhYzFlIn0.Gwl3s301OMWpdEVAVj_T3JZV8bs7N5-V7QNNG7TQ33o
Security	>	JWT
Field Value Example
iss The	URL	of	the	issuer	of	the JWT https://ehr.example.com
aud The	CDS	Service	endpoint	being	called https://example.org/cds-
services/my-service
exp Time	this	JWT	expires 1422568860
iat Time	at	which	this	JWT	was	issued 1311280970
jti Nonce	to	protect against	replay	attacks ee22b021-e1b7-4611-ba5b-
8eec6a33ac1e
sandbox.cds-hooks.org
Separation	of	Concerns
Concern Owner
Workflow	& hooks	(triggers) EHR
CDS	logic CDS Service	Provider
Initial context	data EHR
Additional	data
CDS	Service	Provider
(via	FHIR	or	other	sources)
CDS	presentation EHR
Argonauts	❤	CDS	Hooks
Pushing	SMART	apps	via	a	CDS	Service	upon	opening	
the	patient’s	chart
Validate	and	implement	the	CDS	Hooks	security	model
Roadmap
Release	a	1.0	specification
Q1	2018
Launch	production	pilots
2018
What’s	after	1.0?
Performance:	trigger	guards,	SLAs
Event	&	time	based	hooks
Specific	use	cases
(ACR	ordering	guidelines,	CDC	opioid	guidelines,	etc)
Wait,	doesn’t	FHIR	already
define	an	approach	for	CDS?
Let’s	compare!
Clinical	Reasoning CDS	Hooks
Management
Rule	definition
Local	execution
Remote	execution
What	the?!
More	 wins,	right?
broad vs	narrow
Local	
Decision	
Support
Remote	
Decision	
Support
Clinical	Reasoning
Let	me	predict	your	questions…
Q:	Is	CDS	Hooks	in	production?
A:	Not	yet	:'-(
Q:	Will	CDS	Hooks	support	<insert	feature>?
A:	Log	a	Github	issue	or	let’s	discuss	over
our	Google	Group	or	Zulip	chat!
Let	me	predict	your	questions…
Q:	What	is	the	planned	support	for
<insert	your	favorite	EHR,	hospital,	etc>?
A:	¯_( )_/¯
Q:	What	is	the	business	model	for
CDS	Hooks?
A:	¯_( )_/¯
References
Specification	&	documentation
http://cds-hooks.org
Sandbox
http://sandbox.cds-hooks.org
Source	code
https://github.com/cds-hooks
Let’s	code!
Complete	the	tutorial	and
write	your	own	CDS	Service!
github.com/cerner/cds-services-tutorial
Thanks!
Addendum
Sample	content	from	CDS	vendors	
developing	on	CDS	Hooks
PerfectChoice™
Helping physicians make the perfect antibiotic choices.
STEVENSON,	LAURA
Age:	4	years	 CrCl:	>100mL/min
Allergies:	No	Known	Allergies	 SCr:	0.9gm/dL
Previous	Admit:	01/18/13
NEW	CULTURE	INFORMATION
12/22/14	08:45
Specimen	ID:	00564783
Status:	Prelim
Culture:	Blood
Result:	E.Coli
ID	SUMMARY
Microbiology
012/20/14		Urine	Culture:		E.coli
Antibiotic	Medications:
01/24/13	– 01/25/13		Amoxicillin-clavulanate	150mg	PO	q8h
Flags:
Community-acquired	infection
Isolation
NHSN	Documentation:
None
Change	OrdersDismiss
PerfectChoice	– ID:		New	Organism	Identified
PerfectChoice	OPTIONS
Premier	Memorial	Hospital	– Last	12	mos.
E.Coli	- Specimen	Source	Blood
Antibiotic	Medications	(%	Susceptible)
Ampicillin-Sulbactam	(93%)*
Levofloxacin	(88%)*
Cefazolin (79%)*
SMX-TMP	(76%)*
Gentamicin	(73%)*
IDENTIFY. DECIDE. ACT.
Access the EMR to make the appropriate
medication order decisions.
STEVENSON,	LAURA
Age:	4	years	 CrCl:	>100mL/min
Allergies:	No	Known	Allergies	 SCr:	0.9gm/dL
Previous	Admit:	01/18/13
NEW	CULTURE	INFORMATION
12/22/14	08:45
Specimen	ID:	00564783
Status:	Prelim
Culture:	Blood
Result:	E.Coli
ID	SUMMARY
Microbiology
012/20/14		Urine	Culture:		E.coli
Antibiotic	Medications:
01/24/13	– 01/25/13		Amoxicillin-clavulanate	150mg	PO	q8h
Flags:
Community-acquired	infection
Isolation
NHSN	Documentation:
None
Change	OrdersDismiss
PerfectChoice	– ID:		New	Organism	Identified
PerfectChoice	OPTIONS
Premier	Memorial	Hospital	– Last	12	mos.
E.Coli	- Specimen	Source	Blood
Antibiotic	Medications	(%	Susceptible)
Ampicillin-Sulbactam	(93%)*
Levofloxacin	(88%)*
Cefazolin (79%)*
SMX-TMP	(76%)*
Gentamicin	(73%)*
PerfectChoice Notification: Based on new culture information
and facility antibiogram, the following antinfectives have the
highest likelihood (% susceptible) of effectively treating the
infection.
Source:
Launch Premier TheraDoc for more details.
A Premier Solution
View the best antibiotic options based on
facility antibiogram in context of the patient’s
relevant clinical data to reach the right
decision.
Know the priority patients with new
microbiology results with automated
surveillance that notifies clinicians in their
workflow.
Medication
Management for
Adherence
(CDS Hooks)
Real-time medication adherence insights
delivered directly into workflow during patient visits
Bi-directional communication
to enable users to provide real-time feedback
Real time, workflow
integrated, patient
specific, evidence based
Reduces low-value and
unnecessary care
Stanson Health’s CDS Hooks service
CDS	Hooks	Dose	Calculator
Prevent	ADEs	with	system-calculated,	safe,	patient-specific	doses
• See	common	orders	for	this	patient based	on	their	age	and	the	ordered	drug
• Smart	logic	knows	this	order	should	be	dosed	as	trimethoprim
• Select	from	safe rounded	admin	amounts
Leverages	FDB	Cloud	Connector	web	services	
Calculations	happen	in	real-time	using	current	knowledge	base
Med	ordering	workflow:	pediatric	patient,	sulfamethoxazole/trimethoprim
(CDS	Hooks)
Cds hooks   fhir dev days 2017
Cds hooks   fhir dev days 2017

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