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Biomechanical bone remodeling

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Biomechanical bone remodeling

1. 1. Chun Hoe Ong 11/12/2012 BIEN 430
2. 2.  Mechanical damage fatigue dynamics coupled with bone cell activities in creating bone remodeling models.What is being modeled? The modulus of elasticity as a function of porosityWhat is being changed? Porosity Function
3. 3.  Matlab  Matlab: used as the primary means of recreating the positive control model. Microsoft Excel  Excel: used to validate Matlab’s plots and to recreate equations.
4. 4.  Equation 1 Where E = Young’s modulus p= Porosity Equation 2 Where s= Specific Area p= Porosity
5. 5.  Equation 3 Where E= Absolute Young’s Modulus p= Porosity
6. 6. Positive ControlPlot of Elastic Modulus versus Porosity Plot of Specific Area versus Porosity
7. 7. Physiological Change of Positive ControlGraph of E(p) versus Specific Area Graph of E(p) versus Specific Area(0<p<0.4) (0.4<p<1)
8. 8.  Bone is dynamic tissue that adepts its microstructure to its physiological and mechanical environment. (Consistent with Wolff’s Law)
9. 9.  The original model allows us to determine the optimal porosity to obtain the maximum elastic modulus. Can be used to study long-term effects of mechanical damage on bone recovery. Provides a method of predicting when a bone might fracture.
10. 10.  Can be used in combination of finite element code to asses strategies for knee replacement.Significance of New Model Provides a more accurate method of analyzing bone fractures Demonstrates the effects of change in specific area on the elastic modulus of bone. Allows for a better prediction of bone recovery rate
11. 11. Unexpected Results The modulus of elasticity began to increase as the surface area increased beyond 2.6m-1 for porosity> 0.4 The exponential increase of the Young’s modulus once the surface area increased beyond 2.6m-1 for porosity> 0.4