Belmont Report, published in 1979, is a foundational document in the field of bioethics and research ethics. It was developed by the National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research in response to ethical concerns arising from research misconduct, particularly the infamous Tuskegee Syphilis Study. The Belmont Report outlines three fundamental ethical principles and their applications in research involving human subjects. These principles are often referred to as the Three Benchmark Rules