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Aloe barbadensis Miller!
(Aloe vera) !
Célia Stutz, Florent Waltz, Mickaël Veinante!
Master biologie et valorisation des p...
healing
stimulation
Sugar composition of !
Aloe vera pulp
Major metabolites!
in Aloe vera
II. Gel composition
III. Example...
Introduction
Aloe barbadensis Miller
(Aloe vera)
Liliaceae
family
CAM
metabolism
Found near
tropics
Used as a medicinal
pl...
Does Aloe vera really have
those effects ?
Overview
Gel composition
(Ni and al, 2004)
The sugar composition of Aloe vera pulp
Mannose
Major metabolites
Aloin A !
or B
Aloesin !
& Aloeresin A
(Lee and al, 2012)
2 examples !
a positive effect & a negative effect
A positive effect example : healing stimulation
(Choi and al, 2001)
A negative effect example : Carcinogenic activity
(Boudreau and al, 2012)
mademoiselle-bio.com
A potential toxical compound
➙ Aloin
Many researches focus
on molecules alone, but
association of mol...
Conclusion
Aloe vera has widely been used for a long time!
Researches :!
➙ Understanding of some properties!
➙ Nevertheles...
References
!
• Y. Ni, D. Turner, K.M. Yates, I. Tizard, 2004, Review : Isolation and characterization of structural compon...
Thanks for your attention
G1G1M1DI2 composition
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Aloe barbadensis Miller (Aloe vera)

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L’Aloe vera est une plante à laquelle on attribue de multiples vertus et ce pratiquement depuis l’antiquité. Aujourd’hui la plante se retrouve partout, que ce soit en cosmétique, en pharmacologie, en diététique.
Cette plante est surtout cultivée pour la production de gel d’Aloe vera, le composant majeur des feuilles de la plante ou sont stockées de nombreux métabolites comme les hydrates de carbone, anthraquinones, flavonoïdes, …
Au cours de notre analyse c’est donc naturellement que nous avons d’abord étudié la pulpe d’Aloe vera dont est extrait le gel. Il a été question de comprendre ces éléments structuraux ainsi que les molécules composants le gel. L’effet de la croissance de la plante ainsi que les méthodes de préparation du gel ont aussi été analysé pour comprendre leur influence sur la composition du gel.
Il a ensuite été question des effets pharmacologiques de certaines molécules spécifique. L’aloïne pour ses effets négatifs sur la santé, et une glycoprotéine non caractérisée ayant un effet positif sur la cicatrisation.
L’utilisation du gel d’Aloe vera sur la conservation des fruits a aussi été abordée.
Il ressort de cette analyse que la compréhension des principes actifs de la plante, s’ils existent, restent pour la plupart inconnus, bien que de nombreuses publications attestent d’effets positifs sur la cicatrisation, la stimulation de la réponse immunitaire ou encore de propriétés anticancéreuse.
Il est probable que les effets observés du gel de la plante ne soit pas dus à une seule molécule mais à plusieurs agissant ensembles, ce qui complique la compréhension du mode d’action.

Published in: Healthcare
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Aloe barbadensis Miller (Aloe vera)

  1. 1. Aloe barbadensis Miller! (Aloe vera) ! Célia Stutz, Florent Waltz, Mickaël Veinante! Master biologie et valorisation des plantes! !
  2. 2. healing stimulation Sugar composition of ! Aloe vera pulp Major metabolites! in Aloe vera II. Gel composition III. Examples of both positive and negative effects of Aloe vera gel IV. Criticisms & Conclusion carcinogenic activity I. Introduction
  3. 3. Introduction Aloe barbadensis Miller (Aloe vera) Liliaceae family CAM metabolism Found near tropics Used as a medicinal plant since antiquity
  4. 4. Does Aloe vera really have those effects ?
  5. 5. Overview
  6. 6. Gel composition
  7. 7. (Ni and al, 2004) The sugar composition of Aloe vera pulp Mannose
  8. 8. Major metabolites Aloin A ! or B Aloesin ! & Aloeresin A (Lee and al, 2012)
  9. 9. 2 examples ! a positive effect & a negative effect
  10. 10. A positive effect example : healing stimulation (Choi and al, 2001)
  11. 11. A negative effect example : Carcinogenic activity (Boudreau and al, 2012)
  12. 12. mademoiselle-bio.com A potential toxical compound ➙ Aloin Many researches focus on molecules alone, but association of molecules are often responsible of the effects Economical interest of Aloe vera! ➙ issue of impartiality! ➙ lack of control Many described properties in articles ! ! ➙ sometimes without interest Other Aloes have the same compounds Uses in a lot of areas Criticisms
  13. 13. Conclusion Aloe vera has widely been used for a long time! Researches :! ➙ Understanding of some properties! ➙ Nevertheless, some researches lack of objectivity because of the desire to get a « miracle plant »! Aloe vera is interesting but we need to step back about the properties which are attributed to this plant.! Knock out an enzyme of the aloin biosynthetic pathway Image : aloe-vera-noni.com
  14. 14. References ! • Y. Ni, D. Turner, K.M. Yates, I. Tizard, 2004, Review : Isolation and characterization of structural components of Aloe vera L. leaf pulp, Elsevier, International Immunopharmacology 4 1745–1755! • S.W. Choi, B.W. Son, Y.S. Son, Y.I. Park, S.K. Lee, M.H. Chung, 2001, The wound-healing effect of a glycoprotein fraction isolated from Aloe vera, British Journal of Dermatology 145 535-545.! • M.D. Boudreau, P.W. Mellick, G.R. Olson, R.P. Felton, B.T. Thorn, F.A. Beland, 2012, Clear Evidence of Carcinogenic Activity by a Whole-Leaf Extract of Aloe barbadensis Miller (Aloe vera) in F344/N Rats, toxicological sciences 131(1) 26–39! • D. Paladines, D. Valero, J. M. Valverde, H. D-M, M. Serrano, D. Martínez-Romero, 2014, The addition of rosehip oil improves the beneficial effect of Aloe vera gel on delaying ripening and maintaining postharvest quality of several stonefruit, Elsevier, postharvest biology and technology 92 23–28! • T. Reynolds, A.C. Dweck, 1999, Aloe vera leaf gel: a review update, Elsevier, Journal of Ethnopharmacology 68 3–37! • Mary D. Boudreau and Frederick A. Beland, 2006, An evaluation of the biological and toxicological properties of Aloe barbadensis (Miller), Aloe vera, Journal of environmental science and health part C, 24 103–154! • J.H. Hamman, 2008, Review : Composition and applications of Aloe vera leaf gel, Molecules 13 1599-1616! • S. Lee, S. G. Do, S. Yeou Kim, J. Kim, Y. Jin, C. H. Lee, 2012, Mass Spectrometry-Based Metabolite Profiling and Antioxidant Activity of Aloe vera (Aloe barbadensis Miller) in Different Growth Stages, Journal of agricultural and food chemistry, 60 11222−11228! • V.K. Chandegara, A.K. Varshney, 2013, Aloe vera L. processing and products : a review, Int. J. Med. Arom. Plants, Vol 3, 4 492-506! • B.D. Luccia, N. Manzo, M. Vivo, E. Galano, A. Amoresano, E. Crescenzi, A. Pollice, R. Tudisco, F. Infascelli and V. Calabrò, 2013, A Biochemical and Cellular Approach to Explore the Antiproliferative and Prodifferentiative Activity of Aloe Arborescens Leaf Extract, Phytotherapy research, 27 1819–1828! !
  15. 15. Thanks for your attention
  16. 16. G1G1M1DI2 composition

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