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13/11/2014 
1 
azM 
U 
M 
azM 
Mixed-methods research on care processes in heart failure 
U 
 Communication as major drawback resulting in insufficient treatment 
M 
 Also vividly discussed during dissemination events 
 Knowledge of patients rather poor (despite HF nurses) 
 Level of communication with patients inadequate 
 Quite different priorities in therapy between GP’s and specialists 
Transnational HF network 
Development of patient-centred telemedicine device 
 Patient-education and -monitoring
13/11/2014 
2 
azM 
U 
M 
 Estimate of app. 15 million 
patients in Europe 
 One of the most costly diseases 
 App. 2% of health care budget 
 One of the most malignant diseases 
 Most common reason for hospital-ization 
in pts aged >65years 
 Usually accompanied with multiple 
co-morbidities 
 40% have ≥5 co-morbidities 
20% 
18% 
16% 
14% 
12% 
10% 
8% 
6% 
4% 
2% 
0% 
40 50 60 70 80 90 
Age 
azM 
U 
M 
Clinical input 
Standard regimen according to 
guidelines 
NYHA class 
LVEF, HF‐etiology 
Lab results, ECG 
Signs & Symptoms 
Age, Co‐morbidites, 
Side‐effects
13/11/2014 
3 
azM 
Symptoms, aetiology etc. 
Co-morbidities 
U 
HF-related 
M 
Patient preferences 
Patient knowledge 
Patient capabilities 
Biomarkers (e.g. NT-proBNP, 
sST2) 
miRNA 
Clinical input “Sensor” input 
Patient input 
Enhanced treatment decision 
Drug/Dose regimen A Drug/Dose regimen B Drug/Dose regimen C 
Optimising individual treatment 
Targeted drug use & minimizing side effects 
(decreased medication for same benefit / increased medication for increased benefit) 
related 
Tele-medicine sensors 
(e.g. impedance, BP) 
Development of patient-centred, decision support system, 
which is based on tele-medicine device in order to 
 Improve patient knowledge 
 Transfer large parts of treatment to patients’ home, run by the patients 
 Individualize care of patients 
 Improve communication between all important stakeholders (i.e. 
azM 
U 
M 
patient, GP, cardiologist, other specialists if applicable, heart failure 
nurse if applicable, paramedics as applicable) 
 Improve outcome of patients 
 Reduce costs
13/11/2014 
4 
Which parts are crucial for further development and 
implementation? 
What innovation is required? 
azM 
Impossible to address all aspects in one project 
U 
 Focus on aims that realistically can be achieved 
 Product innovation 
 Service innovation 
 Process innovation 
M 
azM 
Improved communication between all stakeholders of care 
Improved care processes with more patient’s self-management 
ICT infrastructure for coordinated and integrated care 
Improvement in care of chronic diseases 
U 
 GP’s, specialists, paramedicals, and importantly patients 
 Tele-health central (with different focus than at present) 
 Important business opportunities 
 Collaboration academic institutes and industrial partners 
 Tackling the needs of the growing elderly population 
M
13/11/2014 
5 
Influence of different health-care systems unknown, but 
probably much underestimated 
Implementation in different countries not uniform 
Business models may vary in different countries 
azM 
Taking advantage of knowledge in different countries 
U 
 Partners with specific expertise 
M

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Pitch 1 ehv heart failure clinic

  • 1. 13/11/2014 1 azM U M azM Mixed-methods research on care processes in heart failure U  Communication as major drawback resulting in insufficient treatment M  Also vividly discussed during dissemination events  Knowledge of patients rather poor (despite HF nurses)  Level of communication with patients inadequate  Quite different priorities in therapy between GP’s and specialists Transnational HF network Development of patient-centred telemedicine device  Patient-education and -monitoring
  • 2. 13/11/2014 2 azM U M  Estimate of app. 15 million patients in Europe  One of the most costly diseases  App. 2% of health care budget  One of the most malignant diseases  Most common reason for hospital-ization in pts aged >65years  Usually accompanied with multiple co-morbidities  40% have ≥5 co-morbidities 20% 18% 16% 14% 12% 10% 8% 6% 4% 2% 0% 40 50 60 70 80 90 Age azM U M Clinical input Standard regimen according to guidelines NYHA class LVEF, HF‐etiology Lab results, ECG Signs & Symptoms Age, Co‐morbidites, Side‐effects
  • 3. 13/11/2014 3 azM Symptoms, aetiology etc. Co-morbidities U HF-related M Patient preferences Patient knowledge Patient capabilities Biomarkers (e.g. NT-proBNP, sST2) miRNA Clinical input “Sensor” input Patient input Enhanced treatment decision Drug/Dose regimen A Drug/Dose regimen B Drug/Dose regimen C Optimising individual treatment Targeted drug use & minimizing side effects (decreased medication for same benefit / increased medication for increased benefit) related Tele-medicine sensors (e.g. impedance, BP) Development of patient-centred, decision support system, which is based on tele-medicine device in order to  Improve patient knowledge  Transfer large parts of treatment to patients’ home, run by the patients  Individualize care of patients  Improve communication between all important stakeholders (i.e. azM U M patient, GP, cardiologist, other specialists if applicable, heart failure nurse if applicable, paramedics as applicable)  Improve outcome of patients  Reduce costs
  • 4. 13/11/2014 4 Which parts are crucial for further development and implementation? What innovation is required? azM Impossible to address all aspects in one project U  Focus on aims that realistically can be achieved  Product innovation  Service innovation  Process innovation M azM Improved communication between all stakeholders of care Improved care processes with more patient’s self-management ICT infrastructure for coordinated and integrated care Improvement in care of chronic diseases U  GP’s, specialists, paramedicals, and importantly patients  Tele-health central (with different focus than at present)  Important business opportunities  Collaboration academic institutes and industrial partners  Tackling the needs of the growing elderly population M
  • 5. 13/11/2014 5 Influence of different health-care systems unknown, but probably much underestimated Implementation in different countries not uniform Business models may vary in different countries azM Taking advantage of knowledge in different countries U  Partners with specific expertise M