GKA deel 2 college 9

HIV variations ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Science 1993 Yellow: IV drug users Green: Homosexuals Purple: Hemophilia patients

The Libyan HIV drama (Intermezzo) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Back to 1993 Science paper: Cell mediated immunity or B-cell activation? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Pantaleo and Koup, Nature Medicine 8, 2004, 806 Science 1993

T helper 1 versus T helper 2 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object], Interleukine-2, -12, IFN  T H1 --------------------------------| T H2 Interleukine-4, -10 |-------------------------------- IFN  IL-2 IL-4, -5,-6,-6,-10 CMI (CTL) B-cel activatie Geldt dit ook voor HIV???? Science 1993

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Redenen verlies van CD4 + cellen zie ook Greene Sci Am 1993 Science 1993 www.rockefeller.edu/images/syncytia.jpeg

Dying T-cells: syncytia ,[object Object],[object Object],[object Object],Science 1993 www.mcld.co.uk/hiv/images/syncytia.gif

Cytopathogenicity of HIV , F. Barré-Sinoussi, Nature medicine 9, 2003, 844-846 ,[object Object],[object Object],[object Object],Science 1993

Waarom blijven geïnfecteerde personen vrij van AIDS? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Science 1993 (herhaling…)

Co-infection may protect against progression to AIDS Xiang et al., NEJM 345, 2001, 707-714 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],AIDS patients followed over the years

Types of possible vaccines Science 1993 ,[object Object],[object Object],[object Object],[object Object],Science 1993

Proposed model for vaccination ,[object Object],Science 1993

Prime vaccination and boosters ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Seroconversion Science 1993

GKA deel 2 college 9

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