The patient, a 1-year old male, presented with an unusually shaped head and developmental delays. Imaging revealed right unicoronal craniosynostosis requiring total calvarial reconstruction. The anesthetic management involved careful preparation, temperature control, fluid management, and close monitoring during the prolonged surgery due to risks of tube displacement, hypothermia, blood loss, and air embolism. Through meticulous care, the patient successfully underwent reconstruction and was recovered in the ICU with adequate analgesia and hydration.