QC of herbal products ayansh singh

1. A Presentation by-
AYANSH SINGH

2. Amikacin Sulphate
 AMIKACIN IS AN ANTIBIOTIC MEDICATION USED FOR A
NUMBER OF BACTERIAL INFECTIONS. THIS INCLUDES JOINT
INFECTIONS, INTRA-ABDOMINAL INFECTIONS, MENINGITIS,
PNEUMONIA, SEPSIS, AND URINARY TRACT INFECTIONS. IT IS
ALSO USED FOR THE TREATMENT OF MULTIDRUG-RESISTANT
TUBERCULOSIS.
 CHEMICAL FORMULA- C22H45N5O13.2H2SO4
 USE- AS AN ANTIBACTERIAL
 PHYSICAL APPEARANCE- YELLOWISH WHITE CRYSTALLINE
POWDER
 CHEMICAL TEST-
 PH =2.0 – 4.0
 SPECIFIC OPTICAL ROTATION
 CHROMATOGRAPHY

3. Chemical test for amikacin sulphate
Amikacin sulphate (AMK)
is a weakly absorbing UV
compound that shows no
absorbance within the
range of 200–800 nm,
which hinders its analysis
by high performance
liquid chromatography
(HPLC) with a UV
detector.
Therefore, the analysis is
performed by
using high-
performance liquid
chromatography with
diode-array
detection (HPLC-DAD)
method.

4. Bacitracin
Zinc
Bacitracin zinc is a medicine that is used on cuts and other skin wounds to
help prevent infection. Bacitracin is an antibiotic, a medicine that kills germs.
Small amounts of bacitracin zinc are dissolved in petroleum jelly to create
antibiotic ointments.
Chemical formula-C66H103N17O16S.Zn
Use- Antibiotic(antibacterial)
Physical appearance- light yellowish grey powder
Chemical test- ph- 6.0 – 7.5

5. Chemical test for bacitracin zinc
The HPLC method developed
for mass spectrometry was
effective and all components
were determined for the
bacitracin test drug. The
known bacitracin components
were determined as Bacitracin
A, B1, B2, B3, C1, C2, C3, F.

6. Captopril
 Captopril, sold under the brand name
Capoten among others, is an angiotensin-
converting enzyme inhibitor used for the
treatment of hypertension and some types of
congestive heart failure. Captopril was the first
oral ACE inhibitor found for the treatment of
hypertension.
 Chemical formula- C9H15NO3S
 Use- Antihypertensive
 Physical appearance- White crystalline
powder
 Chemical test- Dissolution

7. Chemical tests for captopril
TLC is used for the identification
of captopril
Thin layer chromatography, or
TLC, is a method for analyzing
mixtures by separating the
compounds in the mixture. TLC
can be used to help determine
the number of components in a
mixture, the identity of
compounds, and the purity of a
compound

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