2. OUR CASE
For several weeks , a41 –years- old male has felt
as if is slight drunk all the time.
He can’t walk properly anymore and feels as if he
is in daze.
At first he thought it might be exhaustion but as
it is not improving he wants to know what is wrong
and the prognosis is.
5. INTRODUCTION
The disease was named for Lyme, Connecticut, the town
where it was first diagnosed in 1975 after a puzzling
outbreak of juvenile arthritis.
The organism that causes the disease was identified in
1982 and named for its discoverer,Willy Burgdorfer.
6. DEFINITION OF LYME
DISEASE
It is a tick transmitted infection caused by Borrelia
burgdorferi.
Borrelia are large spirochetes and have endoflagella.
unlike the other bacteria, borrelia species has liner
plasmid.
Lyme disease is classified as a zoonosis.
it’s systemic illness.
7. EPIDEMIOLOGY
It is the most commonly reported tick-borne
illness in the USA and Europe.
It is seasonal disease in occurrence.
8. RISK FACTOR
Geographical location.
Spending time in wooded or grassy areas.
Having exposed skin.
Not removing ticks promptly or properly.
9. CAUSES
Borrelia species: B. burgdorferi, B. afzelii, and B. garinii.
Borrelia species are carried by infected deer ticks
(Ixodes scapularis) and pass it to the humans.
In U.S, the white-footed mouse is the usual host of
immature ticks, while deer are the most common hosts
of the adult ticks.
In Europe, sheep are the usual hosts of adult infected
ticks.
14. REFERENCE
Gale Encyclopedia Of Neurological disorders (p.505-
509).
The Merck Manual of Diagnosis & Therapy, page 1269.
Clinical Microbiology made ridiculously simple book
3th (p.96-98).
Atlas Of Neurology book (p.228-229).
Medical Microbiology made memorable book (p326-
328).
Microbiology Lippincott's book (P164-166)
Editor's Notes
Tried symptoms in encephalitis are: fever, distrusted consciousness and seizure.
Cerebellar tumor: we did MRI and nothing indicate tumor there.
MS: there is no attacks.
In general there is red circular lesion with a clear center eretherma migrans which is indicate the lyme disesse.
Lyme disease was first recognized in 1975 after researchers investigated why unusually large numbers of children were being diagnosed with juvenile rheumatoid arthritis in Lyme, Connecticut, and two neighboring towns. The investigators discovered that most of the affected children lived near wooded areas that harbored ticks. They also found that the children's first symptoms typically started in the summer months coinciding with the height of the tick season. Several of the patients interviewed reported having a skin rash just before developing their arthritis, and many also recalled being bitten by a tick at the rash site.
Is also known as Lyme borreliosis.
Spirochete becteria (spiral-shaped bacterium)
lyme disese is classified as a zoonosis, which mean that it is a disease of animals that can transmitted to humans. (it can’t transmitted person to person).
it’s systemic illness the most commonly affected organs skin, nervous system, heart, joint and eye.
In the central Europe like astralia and solifinia.
Incedince of sothern urope like Italy and portogal and Belgium
It is seasonal disease in occurnece, human are more likely to be infected from may to august. (summer).
It occurs in, China and Japan.
Spending time in wooded or grassy areas. In the United States, deer ticks are most prevalent in the Northeast and Midwest regions, which have heavily wooded areas where deer ticks thrive. Children who spend a lot of time outdoors in these regions are especially at risk. Adults with outdoor occupations also are at increased risk.
Not removing ticks promptly or properly. Bacteria from a tick bite can enter your bloodstream if the tick stays attached to your skin for 36 to 48 hours or longer. If you remove a tick within two days, your risk of acquiring Lyme disease is low.
About 25 % of cases in US are reported in the children younger than 14.
Deer ticks the scientific name ( Ixodes scapularis).
Adult black-legged ticks are hard to detect because of their small size; an adult male tick, for example, is about 0.039 in (1 mm) long. An adult female is slightly larger, about 0.051 in (1.3 mm) long.
B. burgdorferi enters the skin at the site of tick bite.
The tick must be attached in the skin at least 24h to transmit bacteria.
After 3 to 32 days, the organisms migrate locally in the skin around the bite, spread via the lymphatic's to cause regional adenopathy or disseminate in blood to organs or other skin site.
Initially, an inflammatory reaction (erythema migrans) occurs before significant antibody response to infection (serologic conversion).
carditis and atrioventicular block,,