Typhoid fever is a life-threatening illness caused by the Salmonella typhi bacteria, which is usually spread through contaminated food or water. Symptoms include high fever, abdominal discomfort, and diarrhea. If left untreated, it can lead to infections in organs and even death. Vaccines are available to prevent typhoid and come in oral and injectable forms. The Vi polysaccharide vaccine is considered safer and more effective compared to other options, as it stimulates T cells in addition to antibodies for stronger immune response. Vaccines can be administered to infants over 6 months, children 1-4 years old, and adults.

1. Vaccination For Typhoid

2. Vaccination For Typhoid
“The first symptom of typhoid is very high fever reaching the temperature of 104°F.”
Typhoid fever is a life-threatening illness caused by a bacterium known as salmonella typhi. It usually
spreads by the intake of food or water contaminated with faeces from a person infected with the
bacteria. Pitiable living conditions and lack of hygiene and sanitation are the major factors that
contribute to the spread of typhoid. Once ingested, the bacteria multiply in the intestine before entering
the blood and spreading throughout the body.
The first symptom of typhoid is very high fever reaching temperature of 104°F. Other symptoms include
profuse sweating, abdominal discomfort and also diarrhoea. If not treated, it can also cause intestinal
bleeding, infection of the brain, gall bladder, heart and bones and may even result in death.
Typhoid can be controlled by improving lifestyle conditions like hygiene and consuming uncontamined
food. There are also vaccines available thanks to the advances in modern medicine that are very
effective in preventing fever. Two types of vaccines are available. One is administered orally and
contains live attenuated S.typhi. The other vaccine containing surface extracts of S.typhi bacteria, called
Vi capsular polysaccharide, is administered directly into a muscle.
The Vi polysaccharide vaccine is considered safer and more effective compared to the other vaccines.
There are two types of Vi capsular polysaccharide vaccines that are available. These are called Vi
capsular polysaccharide and Vi capsular polysaccharide linked to tetanus toxoid (conjugate) vaccines. Vi
conjugate vaccines incite the specialized cells in the human body known as T cells, which the
Vi polysaccharide is not capable of doing alone.
The engagement of the T cells by the Vi conjugate vaccine improves the quality of antibodies in the body
as well as how they respond to different ailments. Visit Apollo Clinics to get more information about the
vaccines available and their effectiveness. These vaccines can be taken at an interval of three years for
three years. The vaccine can be administered to infants above the age of six months, children between
the ages of one to four years of age and also adults.

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