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Human Immune System
A Memesgatha
— Ambar Mondal
Seeta, ye dono tumhari raksha karenge
Normal Human body
Pathogens
A typical day in the field
Le pathogens coming in throughnatural
openings or wounds
Cancercells and otherdamaged
cells
*Epithelial
Barriers:
I. Part 1: Entry into the body
*Pathogens:
Part I: Entry into the body
*Le
Immune
System:
The Pathogen (with an envelope and glycocalyx coat):
Hey man, why are you looking at me like that?
I’m one of your guy
*Invaders:
(Who still
somehow got
into host body)
Part I: Entry into the body
* Le Macrophage (and other phagocytes) about the newcomer
pathogen and apoptotic cells affected by it
Part 2 : Recognition
When Pathogens see
the mounting
Immune Attack:
Immune System:
Part 2 : Recognition
* Innate cells (now
ready to release
cytokines) to
Pathogens:
Part 2 : Recognition
*Invaders:
(realizing the
situation)
Part 3
Censored
*APCs:
*MHC
presentation by
APCs:
<Under prolonged infection or if Innate
system can’t control the situation anymore>
They:
Part 4: Adaptive Immunity
*Plasma cells, TC cells & NK Cells enter scene*
APCs:
Humoral &
Cellular
Immunity
(after Clonal
propagation):
Killer Cells
(upon being
presented with
Antigen):
Part 4: Adaptive Immunity
Part 4: Cell Killing
Next…
Plasma cells:
TC cells and NK Cells:
<to Pathogens and
damaged cells>
Part 4: Cell Killing
*APCs:
Some
Pathogens:
Censored
Part 4: Cell Killing
<Many host
cells are also
killed>
<Patriotic
body cells>
*Second time Infection*
<Years later, Pathogen
re-enters host’s
body>
Immune System:
Body cells:
*Second time Infection*
*Le IgG and Memory T
cells of Adaptive
Immune System:
Memory Cells of
the Immune
System:
*Second time Infection*
Rest of the body to IgG and Memory T cell:
II. Parasites & Worm Invasion
Eosinophil
Basophil
&
Mast Cell:
QnA with Immune System
Immune cells, how do
you communicate with
each other which we,
pathogens, don’t fully
understand?
Why doesn’t Adaptive
Immune System come
and start working
themselves?
III. Autoimmune Diseases
Immune cells to
some body cells:
*Targeted body cells to Immune System:
Autoimmune Diseases
That person
and Doctors:
Body:
<after awhile>
Autoimmune Diseases & Allergy
Cells of Immune System
(how they should feel):
(how they feel):
vs
IV. Graft Rejection
How do they know if
there are any self or
non-self cells:
Immune System to
allo-grafted tissue:
V. Special Cases
1. Mycobacterium
tuberculosis
to Immune system:
Years later,
when Mtb
reawakens:
Special Cases
3. MR & XR
Streptococcus
aureus:
2. HIV:
Special Cases
Coinfecting viruses contacting one another:
Moral (for Pathogens, of course):
Conclusion about Evolution of resistance:
Immune System Motto
To Immune System:
Still you are the best and also the only one we have
Credits
• Kurzgesagt Immunology Video
• Popular Memes

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Immune System Memesgatha