1. Alyssa M. Driscoll
Phone: 267-471-4438
Email: alyssamdriscoll@gmail.com
Home Address: 1206 Lady Violet Drive, Ambler PA 19002
EXPERIENCE
ASSOCIATE SCIENTIST Biopharmaceutical Downstream Process Development June 2014-present
GlaxoSmithKline, Upper Merion PA
Description: Involved in all aspects of downstream purification processes for biopharmaceutical therapeutic proteins, including
monoclonal, domain, and recombinant antibodies. Responsibilities include initial process screening, step optimization and
characterization, scale-up and tech transfer to both clinical and commercial manufacturing facilities. Utilized techniques such
as Design of Experiments (DOE), High Through Put (HTP) and innovative experimental design for process development.
Extensive experience with affinity and ion-exchange chromatography, depth ultra and diafiltration, and Quality by Design
(QbD) and Control Strategy.
INDEPENDENT RESEARCH Lehigh University Bioengineering Department 2012-2014
Project Title: Defining the Mechanism of Neuropilin 2A Cell Signaling
Description: Employed as research intern through the Howard Hughes Medical Institute, Bio Dynamics Summer Institute.
Following internship, was invited to continue research through Lehigh Universities Independent Research I, II, and III
courses. Worked with interdisciplinary team of graduate students to define the mechanism of transmembrane protein
Neruopilin 2A signal transduction. Responsible for training and supervising other undergraduate students in the lab.
EDUCATION
LEHIGH UNIVERSITY Bethlehem PA May 2014
B.S. with High Honors Bio Engineering, concentration in Cell and Tissue Engineering
Overall GPA: 3.76/4.00
Achievements: Deans List Spring 2011, Fall 2011, Spring 2012, Fall 2012, Fall 2014, Spring 2014
UNIVERISTY OF NEW SOUTH WALES Sydney, Australia Spring 2013
SKILLS
LAB TECHNIQUE
Purification Techniques: Tecan liquid-handling systems, affinity ion-exchange and analytical chromatography, Akta Avant
and Explorer systems, depth ultra viral and diafiltration, continuous centrifugation, dialysis, sonication
Analytical Techniques: CEDEX, SEC HPLC, Caliper, Solo-VPE, nano drop, dynamic light scattering, MALDI mass
spectroscopy, SDS-Page gels, Western blotting, flow cytommetry
Additional Lab Techniques: microscopy, mammalian cell culture, E. Coli expression systems, chemical and electrical
transfection, PCR
PROGRAMMING
Unicorn v5 and v6, Empower, Chemstation, LabChip GX, Statistica, Design Expert, MOE, Matlab, C++, Microsoft Office
PUBLICATIONS AND PRESENTAITONS
Barton R, Driscoll A, Flores S, Madbhair D, Collins T, Iovine MK, Berger B. Cysteins in the Neuropilin2-MAM domain modulate
homooligomerization and signal transduction. Biopolymers. 2015; 104: 371-378.
Driscoll A, Bink L, Scott, B. Exploring the variability of mAb Dynamic Binding Capacities on affinity chromatography resin. Poster
session presented at: GlaxoSmithKline Science Symposium; 2015; Upper Merion, PA
Driscoll A, Barton R, Berger B. Defining the Mechanism of Neuropilin2A Signal Transduction. Poster session presented at: David and
Loraine Freedman Engineering Undergraduate Research Symposium; 2014; Bethlehem, PA
Driscoll A, Barton R, Berger B. Defining the Mechanism of Neuropilin2A Signal Transduction. Poster session presented at: Delaware
Cardiovascular Health and Research Symposium; 2014; Newark, DE
Driscoll A, Barton R, Berger B. Defining the Mechanism of Neuropilin2A Signal Transduction. Poster session presented at: Physics and
Chemistry of Biological System Pennsylvania Networking Meeting; 2012; Bethlehem, PA
Driscoll A. Defining the Mechanism of Neuropilin2A Signal Transduction and how to get involved in undergraduate research.
Bioengineering Sophomore Seminar BIOE 020. Bethlehem, PA. 2012-2013. Guest Lecturer.
ACITIVITES AND INTERESTS
American Chemical Society Member: 2014-present
PEER TUTOR for Mechanics and Materials and Electromagnetism and Optics 2012
TOUR GUIDE College of Engineering, Lehigh University 2012
Society of Women Engineers, Lehigh University Member: 2011-2014
Biomedical Engineering Society, Lehigh University Member: 2011-2014