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Tuberculosis
The liver
T.B. of the liver may arise from:-
a- Congenital infection  the umbilical vein.
b- From primary intestinal T.B  "the portal l.n. receive afferent
lymph ties from the duodenum"
c- From infected lungs  intestines  mesenteric liens  fine
branches of portal vein.
d- Through hamates genus route.
e- Sec. extension from T.B. of peritoneum , intestine or
mesenteric l.ns "but on the other hand.T.B.of post Mediastinal
l.n. may be due to lymphatic drainage from T.B. liver."
The lesion in cattle are:-
Nodular encapsulated foci or like small encapsulated abscesses.
The lesions in pigs as mention before.
The spleen
● T.B. of the spleen of calves  congenital inf. the nodules
are present on the surface.
● If the T.B. nodules present in splendid substance  This
mean hamates genus spread  primary inf.  The animal
die before develop of lesion.
● If the lesion are chronic  undergo cassation and
calcification .
In pig : T.B. mostly found in the substance of spleen .
This mean  tendancy to generalization.
The kidney
►T.B. of the kidney mean haematogenous spread.
►T.B. of boviune kidney  appear as small isolated nodules
 distributed in sub tissues of the kidney  involve the
whole of kidney lobules  the surface is irregular ,grayish
white in color on section of the kidney subs  there is
caseation.
►T.B. (Miliary T.B.) of kidney cortex indicate Acute
generalization.
►T.B. in renal Lns come from T.B. peritoneum by lymph
drainage.
► In Pigs  T.B. nodules are very small and few in number
(Difficult to detect)
Stomach and intestines
 Primary infection of the intestinal tract  more common in
swine than in cattle.
►In Cattle:
● Break down from the lungs  stomach + Intestine  T.B.
nodules and ulcers of the intestinal mucosa are rare 
Commonly in mesenteric Lns.
● In Ileum the nodules may coalesce to form ulcers of varying
size (round or oval) covered with grayish mucopurulent
material.
Udder
►T.B. of the udder may result from:
a-haematogenous spread.
b-extension from abdominal lesion.
c-the injection of the bacilli via the teats.
►in early stages of the disease:
The T.B. nodules are recognized by their orange color in contrast
to the normal yellowish white color of the udder tissue.
►Then the affection may show in one of the following forms:
1-chronic diffuse granulomatus forms:
Udder
►it is most common form of T.B.
●in beginning appear as grayish red orange brown hand, and
glistening nodules.
●L.n. is not affected.
●in advanced cases, there are hand hard nodules at the size
of a fist, projecting form the surrounding interlobular C.T.
 caseation
●cut surface has a grayish red of coarse granular surface.
2-disseminating military udder T.B.:
●small fatty nodules  show caseation, calcification
●L.ns always affected.
●This form difficult to recognize as in lactating period 
Udder
It has the same color of udder and projecting
3-Caseous mastitis:
●it appear as a map.
●the nodules are caseatod especially blood spots.
●L.ns are always affected.
Bones and joints
 In ox: commonly in ribs of vertebrae yellow
granulation tissue especially thinning ratification of the
cortex and spongy tissue of the bone.
 In pig: T.B. in bodies and spinal processes of lumber
vert. ischiopubic symphysis and femur.
C.N.S.
T.B. in C.N.S. indicates heamato genous spread.
Skin
T.B. of skin  hard painless nodules single or multiple varying
in size up to a hens egg.
If multiple  appear as a chain on subcut. lymphatic vessels of
limbs, rarely on chest wan and shoulder.
On section  there is a fibrous wall enclosing a casco
calcarcous center or dried material like powdered maize or
flake like pellicle.
Lecturer 11

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Lecturer 11

  • 1.
  • 3. The liver T.B. of the liver may arise from:- a- Congenital infection  the umbilical vein. b- From primary intestinal T.B  "the portal l.n. receive afferent lymph ties from the duodenum" c- From infected lungs  intestines  mesenteric liens  fine branches of portal vein. d- Through hamates genus route. e- Sec. extension from T.B. of peritoneum , intestine or mesenteric l.ns "but on the other hand.T.B.of post Mediastinal l.n. may be due to lymphatic drainage from T.B. liver." The lesion in cattle are:- Nodular encapsulated foci or like small encapsulated abscesses. The lesions in pigs as mention before.
  • 4. The spleen ● T.B. of the spleen of calves  congenital inf. the nodules are present on the surface. ● If the T.B. nodules present in splendid substance  This mean hamates genus spread  primary inf.  The animal die before develop of lesion. ● If the lesion are chronic  undergo cassation and calcification . In pig : T.B. mostly found in the substance of spleen . This mean  tendancy to generalization.
  • 5. The kidney ►T.B. of the kidney mean haematogenous spread. ►T.B. of boviune kidney  appear as small isolated nodules  distributed in sub tissues of the kidney  involve the whole of kidney lobules  the surface is irregular ,grayish white in color on section of the kidney subs  there is caseation. ►T.B. (Miliary T.B.) of kidney cortex indicate Acute generalization. ►T.B. in renal Lns come from T.B. peritoneum by lymph drainage. ► In Pigs  T.B. nodules are very small and few in number (Difficult to detect)
  • 6. Stomach and intestines  Primary infection of the intestinal tract  more common in swine than in cattle. ►In Cattle: ● Break down from the lungs  stomach + Intestine  T.B. nodules and ulcers of the intestinal mucosa are rare  Commonly in mesenteric Lns. ● In Ileum the nodules may coalesce to form ulcers of varying size (round or oval) covered with grayish mucopurulent material.
  • 7. Udder ►T.B. of the udder may result from: a-haematogenous spread. b-extension from abdominal lesion. c-the injection of the bacilli via the teats. ►in early stages of the disease: The T.B. nodules are recognized by their orange color in contrast to the normal yellowish white color of the udder tissue. ►Then the affection may show in one of the following forms: 1-chronic diffuse granulomatus forms:
  • 8. Udder ►it is most common form of T.B. ●in beginning appear as grayish red orange brown hand, and glistening nodules. ●L.n. is not affected. ●in advanced cases, there are hand hard nodules at the size of a fist, projecting form the surrounding interlobular C.T.  caseation ●cut surface has a grayish red of coarse granular surface. 2-disseminating military udder T.B.: ●small fatty nodules  show caseation, calcification ●L.ns always affected. ●This form difficult to recognize as in lactating period 
  • 9. Udder It has the same color of udder and projecting 3-Caseous mastitis: ●it appear as a map. ●the nodules are caseatod especially blood spots. ●L.ns are always affected.
  • 10. Bones and joints  In ox: commonly in ribs of vertebrae yellow granulation tissue especially thinning ratification of the cortex and spongy tissue of the bone.  In pig: T.B. in bodies and spinal processes of lumber vert. ischiopubic symphysis and femur.
  • 11. C.N.S. T.B. in C.N.S. indicates heamato genous spread.
  • 12. Skin T.B. of skin  hard painless nodules single or multiple varying in size up to a hens egg. If multiple  appear as a chain on subcut. lymphatic vessels of limbs, rarely on chest wan and shoulder. On section  there is a fibrous wall enclosing a casco calcarcous center or dried material like powdered maize or flake like pellicle.