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PROPTOSIS
BY,
DR.AKHIL TOLETY
DEFINITION
• PROPTOSIS refers to forward displacement of
the eyeball beyond the orbital margins.
• EXOPTHALMOS is synonymous but used for
the displacement associated with thyroid
disease.
PROPTOSIS EXOPHTHALMOS
CLASSIFICATION
• UNILATERAL PROPTOSIS
• BILATERAL PROPTOSIS
• ACUTE PROPTOSIS
• INTERMITTENT PROPTOSIS
• PULSATING PROPTOSIS
ETIOLOGY
• UNILATERAL PROPTOSIS:
Congenital: Dermoid cyst
Congenital cystic eyeball
Orbital teratoma
Traumatic: Orbital hemorrhage
Retained intraorbital FB
Traumatic aneurysm
Emphysema of orbit
Inflammatory Lesions:
Acute: Orbital cellulitis
Abscess
Panopthalmitis
Thrombophlebitis
Cavernous sinus thrombosis
Chronic: Pseudotumours
Tuberculoma
Gumma
Sarcoidosis
• Circulatory Disturbances and Vascular Lesions:
Angioneurotic edema
Orbital varix
Aneurysms
• Cysts of orbit:
Hematic cyst
Implantation cyst
Hydatid cyst and cysticercus cellulosae
• Tumours:
Primary, Secondary or Metastatic
• Mucocele of Paranasal sinus:
Frontal, Ethmoidal, Maxillary sinus
• BILATERAL PROPTOSIS:
Developmental Anomalies of Skull:
Craniofacial dysostosis
Osteopathies:
Osteitis deformans
Rickets
Acromegaly
Inflammatory Conditions:
Mikulicz’s Syndrome
Late stage of cavernous sinus
Thrombosis
MIKULICZ’S SYNDROME
• Endocrinal Exopthalmos:
Thyrotoxic or Thyrotropic
• Tumours:
Lymphosarcoma
Ewing’s Sarcoma
Leukemic infiltration
• Systemic disease:
Histiocytosis
Systemic amyloidosis
Wegener’s granulomatosis
Orbital Lymphoma
• INTERMITENT PROPTOSIS:
Appears and disappears on its own.
Causes: Periodic orbital edema , Orbital Varix
Recurrent Orbital Hemorrhage, Highly vascular tumours
• PULSATING PROPTOSIS:
Causes: Caroticocavernous Fistula
Sacular aneurysm of Opthalmic Artery
Congenital Meningocele
Neurofibromatosis
APPROCH
INVESTIGATION OF PROPTOSIS
I. CLINICAL EVALUATION
HISTORY: Age of onset
Nature of onset
Duration
Progression
Chronology of orbital signs and symptoms
• LOCAL EXAMINATION:
 INSPECTION:
a.) differentiate proptosis from pseudoproptosis.
b.) ascertain whether proptosis is unilateral or
bilateral.
c.) note the shape of skull.
d.) to observe whether protosis is axial or eccentric.
PALPATION:
It should be carried out for retrodisplacement of
globe to know:
a.) Compressibility of the tumour
b.) For orbital thrill
c.) Any swelling around the eyeball
d.) Regional lymph nodes and orbital rim
 AUSCULTATION:
Search for abnormal vascular communications that
generate a bruit such as caraticocavernous fistula.
• TRANSILLUMINATION:
Helpful in evaluating anterior orbital lesions.
• VISUAL ACUITY:
Orbital lesions reduce visual acuity by-
a.) refractive changes due to pressure on back of
eyeball.
b.) optic nerve compression.
c.) exposure keratopathy
• PUPIL REACTIONS :
Presence of Marcus Gunn pupil is suggestive of optic
nerve compression.
• FUNDOSCOPY :
May reveal
venous engorgement ,
hemorrhage
papilloedema
and optic atrophy.
• OCULAR MOTILITY:
It is restricted in thyroid opthalmopathy, extensive
tumour growths and neurological deficit.
• EXOPTHALMOMETRY :
It measures the protusion of the apex of cornea from
the outer orbital margin (with the eyes looking
straight ahead).
Normal values vary between 10 and 21 mm and are
symmetrical in both eyes.
A difference of more than 2 mm between the two eyes
is considered significant.
• The simplest instrument to measure proptosis is
Luedd’s exopthalmometer.
The Hertel’s exopthalmometer is most commonly
used instrument as it measures the two eyes
simultaneously.
• SYSTEMIC EXAMINATION :
Rule out systemic causes of proptosis such as
 Thyrotoxicosis
 Histiocytosis
 Primary tumour elsewhere in the body.
Otorhinolaryngological examination is necessary
when the nasopharyngeal mass appears to be a
etiological factor.
LAB INVESTIGATIONS
• Hematological studies -TLC , DLC , ESR , VDRL test
• THYROID FUNCTION TESTS
• Casoni’s test (rule out for hydatid cyst)
• Stool examination for cysts and ova
• Urine analysis for Bence Jones proteins for multiple
myeloma
IMAGING TECHNIQUES
 NON INVASIVE TECHNIQUE :
1. Plain X-rays
2. Computed tomography scanning
3. Ultrasonography
4. Magnetic resonance imaging (MRI)
 INVASIVE PROCEDURES:
1. Orbital venography
2. Carotid angiography
3. Radioisotopes studies.
MRI OF PROPTOSIS
HISTOPATHOLOGICAL STUDIES
• FINE-NEEDLE ASPIRATION BIOPSY
• INCISIONAL BIOPSY
• EXCISIONAL BIOPSY
MANAGEMENT OF PROPTOSIS
• GENERAL- Lubricants
Tapping eyelids
Cold compresses
• SYSTEMIC STEROIDS –
Oral Prednisolone = 60-80mg/day
tappered over 2-8 wks
i.v methylprednisolone = 0.5g/200ml
isotonic saline infusion for 30 mins
• Radiotherapy
• Combined therapy -
Radiations + Azathioprine + Steroids
• Surgical decompression
PROPTOSIS

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PROPTOSIS

  • 2. DEFINITION • PROPTOSIS refers to forward displacement of the eyeball beyond the orbital margins. • EXOPTHALMOS is synonymous but used for the displacement associated with thyroid disease.
  • 4. CLASSIFICATION • UNILATERAL PROPTOSIS • BILATERAL PROPTOSIS • ACUTE PROPTOSIS • INTERMITTENT PROPTOSIS • PULSATING PROPTOSIS
  • 5. ETIOLOGY • UNILATERAL PROPTOSIS: Congenital: Dermoid cyst Congenital cystic eyeball Orbital teratoma Traumatic: Orbital hemorrhage Retained intraorbital FB Traumatic aneurysm Emphysema of orbit
  • 6. Inflammatory Lesions: Acute: Orbital cellulitis Abscess Panopthalmitis Thrombophlebitis Cavernous sinus thrombosis Chronic: Pseudotumours Tuberculoma Gumma Sarcoidosis
  • 7. • Circulatory Disturbances and Vascular Lesions: Angioneurotic edema Orbital varix Aneurysms • Cysts of orbit: Hematic cyst Implantation cyst Hydatid cyst and cysticercus cellulosae • Tumours: Primary, Secondary or Metastatic • Mucocele of Paranasal sinus: Frontal, Ethmoidal, Maxillary sinus
  • 8. • BILATERAL PROPTOSIS: Developmental Anomalies of Skull: Craniofacial dysostosis Osteopathies: Osteitis deformans Rickets Acromegaly Inflammatory Conditions: Mikulicz’s Syndrome Late stage of cavernous sinus Thrombosis
  • 10. • Endocrinal Exopthalmos: Thyrotoxic or Thyrotropic • Tumours: Lymphosarcoma Ewing’s Sarcoma Leukemic infiltration • Systemic disease: Histiocytosis Systemic amyloidosis Wegener’s granulomatosis
  • 12. • INTERMITENT PROPTOSIS: Appears and disappears on its own. Causes: Periodic orbital edema , Orbital Varix Recurrent Orbital Hemorrhage, Highly vascular tumours
  • 13. • PULSATING PROPTOSIS: Causes: Caroticocavernous Fistula Sacular aneurysm of Opthalmic Artery Congenital Meningocele Neurofibromatosis
  • 14.
  • 16. INVESTIGATION OF PROPTOSIS I. CLINICAL EVALUATION HISTORY: Age of onset Nature of onset Duration Progression Chronology of orbital signs and symptoms
  • 17. • LOCAL EXAMINATION:  INSPECTION: a.) differentiate proptosis from pseudoproptosis. b.) ascertain whether proptosis is unilateral or bilateral. c.) note the shape of skull. d.) to observe whether protosis is axial or eccentric.
  • 18. PALPATION: It should be carried out for retrodisplacement of globe to know: a.) Compressibility of the tumour b.) For orbital thrill c.) Any swelling around the eyeball d.) Regional lymph nodes and orbital rim
  • 19.  AUSCULTATION: Search for abnormal vascular communications that generate a bruit such as caraticocavernous fistula.
  • 20. • TRANSILLUMINATION: Helpful in evaluating anterior orbital lesions. • VISUAL ACUITY: Orbital lesions reduce visual acuity by- a.) refractive changes due to pressure on back of eyeball. b.) optic nerve compression. c.) exposure keratopathy
  • 21. • PUPIL REACTIONS : Presence of Marcus Gunn pupil is suggestive of optic nerve compression. • FUNDOSCOPY : May reveal venous engorgement , hemorrhage papilloedema and optic atrophy.
  • 22. • OCULAR MOTILITY: It is restricted in thyroid opthalmopathy, extensive tumour growths and neurological deficit.
  • 23. • EXOPTHALMOMETRY : It measures the protusion of the apex of cornea from the outer orbital margin (with the eyes looking straight ahead). Normal values vary between 10 and 21 mm and are symmetrical in both eyes. A difference of more than 2 mm between the two eyes is considered significant.
  • 24. • The simplest instrument to measure proptosis is Luedd’s exopthalmometer. The Hertel’s exopthalmometer is most commonly used instrument as it measures the two eyes simultaneously.
  • 25. • SYSTEMIC EXAMINATION : Rule out systemic causes of proptosis such as  Thyrotoxicosis  Histiocytosis  Primary tumour elsewhere in the body. Otorhinolaryngological examination is necessary when the nasopharyngeal mass appears to be a etiological factor.
  • 26. LAB INVESTIGATIONS • Hematological studies -TLC , DLC , ESR , VDRL test • THYROID FUNCTION TESTS • Casoni’s test (rule out for hydatid cyst) • Stool examination for cysts and ova • Urine analysis for Bence Jones proteins for multiple myeloma
  • 27. IMAGING TECHNIQUES  NON INVASIVE TECHNIQUE : 1. Plain X-rays 2. Computed tomography scanning 3. Ultrasonography 4. Magnetic resonance imaging (MRI)  INVASIVE PROCEDURES: 1. Orbital venography 2. Carotid angiography 3. Radioisotopes studies.
  • 29. HISTOPATHOLOGICAL STUDIES • FINE-NEEDLE ASPIRATION BIOPSY • INCISIONAL BIOPSY • EXCISIONAL BIOPSY
  • 30. MANAGEMENT OF PROPTOSIS • GENERAL- Lubricants Tapping eyelids Cold compresses • SYSTEMIC STEROIDS – Oral Prednisolone = 60-80mg/day tappered over 2-8 wks i.v methylprednisolone = 0.5g/200ml isotonic saline infusion for 30 mins
  • 31. • Radiotherapy • Combined therapy - Radiations + Azathioprine + Steroids • Surgical decompression