1. Biocatalysis for Our Sustainable Future
whattheythink.com

2. Chemical Processing: Fueling the 20th Century
Straathof et al. Curr. Opin. Biotech. 13, 548-556, 2002

3. Biocatalysis: Fueling the 21st “Sustainable” Century
Chemicals
Fuels
Drugs

4. From Nature (1.3 billion tons)…

5. …to Products Through Biorefining

6. Challenges to Overcome
Ionic Liquids
scidac.org
Cellulase

7. Biocatalysis for Healthcare
OH
O
O OH
OH
OCH3 O OH O NH2
O
OH

9. Drug Discovery at a Crossroads
$2 billion/approval?
Source: Burrill & Co.

10. Biology’s Complexity

11. Biocatalysis-
driven
Drug Discovery
Human Toxicity
=

12. Developing Better Biocatalytic Materials

13. From Enzymology to Enzyme-Based Materials
Nanoscale Materials Designed Gels
Enzymes Biocatalytic
Plastics
Biocatalytic
Coatings
Up in Space

14. Exploiting Nature’s Composite Materials
Biomimetic,
Biocatalytic Coating
CYP3A4
100 nM Ketoconazole
250 nM Sulfaphenazole
CYP2C9 10 nM Quinidine
100 nM Ketoconazole
Biocatalytic 250 nM Sulfaphenazole
Plastics 10 nM Quinidine
CYP2D6
100 nM Ketoconazole
250 nM Sulfaphenazole
10 nM Quinidine
)
)
)