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Lecture 1 hemostasis first secion
Lecture 1 hemostasis first secion
Lecture 1 hemostasis first secion
Lecture 1 hemostasis first secion
Lecture 1 hemostasis first secion
Lecture 1 hemostasis first secion
Lecture 1 hemostasis first secion
Lecture 1 hemostasis first secion
Lecture 1 hemostasis first secion
Lecture 1 hemostasis first secion
Lecture 1 hemostasis first secion
Lecture 1 hemostasis first secion
Lecture 1 hemostasis first secion
Lecture 1 hemostasis first secion
Lecture 1 hemostasis first secion
Lecture 1 hemostasis first secion
Lecture 1 hemostasis first secion
Lecture 1 hemostasis first secion
Lecture 1 hemostasis first secion
Lecture 1 hemostasis first secion
Lecture 1 hemostasis first secion
Lecture 1 hemostasis first secion
Lecture 1 hemostasis first secion
Lecture 1 hemostasis first secion
Lecture 1 hemostasis first secion
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Lecture 1 hemostasis first secion

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graphics based slides created for teaching by webzmedlectures

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Transcript

  • 1. Webzmedlectures WML DISORDERS AFFECTING HEMOSTASIS
  • 2. DEFINITION
  • 3. HOW DOES THE BODY REPSOND TO THIS?
  • 4. ANSWER
  • 5. TECHNICALLY • WHAT IS HEMOSTASIS: It is a complex physiological respond of the body to insult brought about by bleeding,based on the interaction of : • Plasma factors • Thrombocytes or platelets • Blood vessel.
  • 6. STAGES OF HEMOSTASIS
  • 7. CLOTH DISSOLUTION
  • 8. VESSEL SPASM
  • 9. HOW DOES IT HAPPEN (SPASM OF VESSELS) • 1. The endothelial cells send information to the smooth muscle cell and this causes their contraction. • Information is related to the smooth to the nerve innervation of the smooth muscle
  • 10. PLATELET PLUG FORMATION
  • 11. ORIGINATE FROM MEGAKARYOCYTES
  • 12. STEPS IN PLUG FORMATION • PLATELETS ACTIVATION • ADHESION OF LATELETS • AGGREGATION OF PLATELETS.
  • 13. PLATELET ACTIVATION • Factors that activate platelets are release from their cytoplasm, and they include • 1.ADP • 2.Serotonin • 3.PDGF, (platelet derived growth factor) • Platelet factor 4
  • 14. WHAT HAPPEN WHEN THEY ARE ACTIVATED? • When platelets are activated they change their shape from a disc shape to a spherical shape • This change of shape helps them to obtain the ability to adhere and aggregate.
  • 15. ADHESION
  • 16. AGGREGATION
  • 17. We get the platelet plug or the primary hemostatic plug.
  • 18. COAGULATION CASCADE • Main purpose is to stabilize and strengthens the platelet plug • To form the fibrin mesh that give that stability required.
  • 19. Definition • Coagulation cascade is a complex biological process that leads to the conversion of soluble plasma fibrinogen to fibrin. • 3 main stages • -formation of thromboplastine comlex • -transformation of prothrombin to Thrombin .-transformation of fibrinogen to fibrin
  • 20. Factors INVOLVED
  • 21. THEIR INTERACTIONS
  • 22. LIMITATION OF COAGULATION • It is a good thing that this process is restricted to the particular region involve in the insult,this is achieved by inhibitors of activated coagulation factors, and fibrinolysis
  • 23. FIBRINOLYTIC SYSTEM • This process leads to the restoration of vessel potency, that is the continuity of the vessel.
  • 24. HOW IT HAPPENS !!

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