Processing Skids for Bio Pharmaceutical and Pharmaceutical Mixing Applications

1. Vishal Wagh
Director
Marketing
www.adamfabriwerk.com 1

2. Summary Indian Ethos
Company
Overview
Manufacturing
Site
Product Profile
Projects
International
Presence
www.adamfabriwerk.com 2

3. Summary Indian Ethos
Company
Overview
Manufacturing
Site
Product Profile
Projects
International
Presence
www.adamfabriwerk.com 3

4. Company Overview
Adam Fabriwerk has been Mumbai To Nashik
delivering quality mixing
and processing machinery
products to
Biopharmaceutical,
Pharmaceutical and
Cosmetic Industries for
the past 26 years
Our corporate offices are
based in Mumbai, India
and our Manufacturing
Facilities and R&D labs
are located at Nashik,160
kms away from Mumbai Nashik Works
Strength : 150 people
www.adamfabriwerk.com 4

5. Company Overview :Board of Directors
Waman Wagh
Technical Director
Devidas Shirude
Finance Director
Sanjay Shirude
Production Director Vishal Wagh
Marketing Director
www.adamfabriwerk.com 5

6. Summary Indian Ethos
Company
Overview
Manufacturing
Site
Product Profile
Projects
International
Presence
www.adamfabriwerk.com 6

7. Manufacturing Site
Fabrication Facility
In house
Design,Manufacturing,FAT
facilities
Orbital Welding machines with
Boroscopy for Tubes
Overhead Cranes covering
Complete Factory Bay areas for
Material Handling
Total Fabrication area availability
1800 Sq.Metres
Maximum Capacity of Vessel
fabrication 30000 Litres
Polishing Bays separate from
Fabrication and Assembly areas
Vessel Design as per ASME BPE-
2005 and ASME Sec VIII Div 1
Qualified Welders as per ASME
Sec IX
www.adamfabriwerk.com 7

8. Manufacturing Site
Display Facility
Operator Training Modules
Prospective Clients get a
first hand look at the end
product
Ease of finalising specific
process critical accessories
and fitments
Mixing/Blending
Vessels,CIP,SIP Modules and
Cream Mixers on Display
with Full Process Control
Options with Production
Scale Models
All World Class Bought outs
used in Integration of the
Skids on Display
www.adamfabriwerk.com 8

9. Manufacturing Site
FAT Area
Vessel Hydro Tests
Jacket Hydro Tests
Vessel/Jacket Vacuum
Tests
Mixing Water Trials
Full BOQ/MOC
Documentation Dossiers
including DQ/IQ/OQ/PLC
Validation Packages
available
Full Operational Tests
performed under FAT
Welding Maps with X ray
Reports
Surface Finish Test with
Profilometer
Electropolishing Reports
Riboflavin Tests for
Sprayball Efficacy
www.adamfabriwerk.com 9

10. Manufacturing Site
New State-of-the-Art
Facility
This new facility is designed for
the fabrication of 100 percent
stainless steel projects. Unit 2
The plant will boast of a controlled
environment ensuring high purity
and cross contamination
prevention to comply with
regulatory standards.
It will also incorporate automated
welding processes and advanced
finishing processes as well as a
designated area for factory
acceptance testing.
With a height of 31 feet under
hook and a 50 ton lift capacity, it
is ideal for large or small tanks as
well as super skids.
www.adamfabriwerk.com 10

11. Summary Indian Ethos
Company
Overview
Manufacturing
Site
Product Profile
Projects
International
Presence
www.adamfabriwerk.com 11

12. Product Profile : Blending Vessels
Mixing Applications
Bacteria and Cell Cultures
Suspensions
Blood fractions in Cohn
fractionation
Vaccine suspensions containing
aluminium hydrogel, salts,
antibodies
Dissolving glucose in water (LVP
solutions)
Capacity
5 to 30000 Litres
www.adamfabriwerk.com 12

13. Product Profile : Blending Vessels
Sterile Sampling System with
In Situ Steam Sterilization
Sterile Flange Connections for
Top dish nozzles to enhance
CIP,SIP operations
Temperature/pH/Conductivity
sensing through sanitary
knuckle port on vessel shell
Load Cells for weight
measurement
Vessel with CIP / SIP able
accessories
PLC system with SCADA
available for batch records
www.adamfabriwerk.com 13

14. Product Profile : Blending Vessels
GMP Mixer
General Mixing
The GMP mixer is suitable for general
Mixing,Blending,Heat transfer and Shear
Sensitive Applications
Speed variation from 20 to 350 RPM
Upstream processing
The USM mixer is a superior alternative to USM Mixer
top-mounted mixers in upstream mixing
applications
The USM mixer creates medium high-
shear forces and transfers much more
energy into the tank than the GMP mixer,
and is ideal for mixing difficult powders
into a liquid
Speed variation from 300 to 1440 RPM
www.adamfabriwerk.com 14

15. Product Profile : Blending Vessels
HS Mixer
Rotor
High Shear Mixing Applications
Homogenizing-Dispersing activities
Stator
Suspension of Solid Particles in Liquid Phase
Dissolving and Downsizing Particles for
Suspension Manufacturing
Emulsification to achieve small Droplet Size to
achieve Stable Emulsions Tank Plate
Speed variation from 400 to 2800 RPM
Combo Mixing
High Shear Combo Mixing
A HS mixer creates the High Shear Forces needed
to create an Emulsion, while the GMP mixer is
used to break the vortex and create additional
Drive
agitation and balance in the tank
A variety of powerful results can be achieved this
way, such as controlling vortex to prevent
foaming, increased agitation, etc.
www.adamfabriwerk.com 15

16. Product Profile : Blending Vessels
Take Off Tank Outlet
Valve Configurations
Take Off Valves
Used in PW and WFI Loops, free of Dead Legs and
No Pressure Drop over the valve in the main line
Tank Outlet Valves
Truly Zero Dead Leg with Multiple ports and
Actuation options
Shut Off Flow Through
Shut Off Valves
Positive Sealing with no cavities, Full Drainability
and Low Pressure Drop
Flow Through Valves
Manifold, Take Off and Drainage Valves in Aseptic
Applications
www.adamfabriwerk.com 16

17. Product Profile : Blending Vessels
LVP
Project
Profiling
Photo Courtesy:Charak Pharmaceuticals
www.adamfabriwerk.com 17

18. Product Profile : Blending Vessels
LVP Project Profiling
www.adamfabriwerk.com 18

19. Product Profile : Blending Vessels
LVP Preparation
tanks
Jacketed/Insulated/Cladded Vessel
Bottom Entry Propeller Mixer for
vigorous MASS MOVEMENT within
the vessel
Bottom Entry Magnetic mixer
mounted within the vessel
Lug Mounted Vessel on Platform
with Load cells
Mixing of 10000 litres of water
www.adamfabriwerk.com 19

20. Product Profile : Blending Vessels
Transfer Panels
Panel Design
Jumper Design
Jumper Holders
Port Caps
Drain Pan
Proximity Switches Photo Courtesy:
Johnson & Johnson
Panel Support
Panel and Port Labeling
www.adamfabriwerk.com 20

21. Product Profile : CIP System
Applications :
Cleaning In Place of
Cream Manufacturing Vessel
Intermediate Preparation
Vessels
Storage Vessels
Product Transfer lines
Photo Courtesy: Encube Ethicals
www.adamfabriwerk.com 21

22. Product Profile : CIP System
Completely Automated Process Cycles
of Pre Wash/Air blow/Detergent
Wash/Rinse /Drying
On line display of process parameters
with P & I of Operating System
Real Time Recording and Print
/Communication of Process Parameters
Detergent / Acid / Alkali Automated
Dosing system
On Line pH,Conductivity, TOC Sensing
CIP is designed in accordance with
ASME BPE guidelines
PLC-based, with Touch Screen MMI and
SCADA Packages
www.adamfabriwerk.com 22

23. Product Profile : CIP System
Key Benefits of CIP
Process
Validatable process for cleaning
of process equipment
Lower facility operating costs
Minimal dismantling of
Cleaning In Place Cycle
equipment and piping
Reduced turnaround time for
cleaning
WFI requirements for cleaning
reduced significantly
Exposure to hazardous activities
or entry into tanks, is
eliminated
www.adamfabriwerk.com 23

24. Product Profile : CIP System
Key Benefits of CIP
Process
Validatable process for cleaning
of process equipment
Lower facility operating costs
Minimal dismantling of
equipment and piping
Reduced turnaround time for
cleaning
WFI requirements for cleaning
reduced significantly
Exposure to hazardous
activities or entry into tanks, is
eliminated
www.adamfabriwerk.com 24

25. Product Profile : CIP System
Flow Characteristics and
Measurement
Sanitary
Flow meter
www.adamfabriwerk.com 25

26. Product Profile : CIP System
PID
Of
Plant wide
CIP
System
www.adamfabriwerk.com 26

27. Automation
HMI Screens : Manufacturing Vessel
www.adamfabriwerk.com 27

28. Automation
HMI Screens : Phase Preparation Vessel
www.adamfabriwerk.com 28

29. Automation
HMI Screens : Product Preparation Steps
www.adamfabriwerk.com 29

30. Automation
HMI Screens : CIP System
www.adamfabriwerk.com 30

31. Automation
HMI Screens : CIP System Steps
www.adamfabriwerk.com 31

32. Summary Indian Ethos
Company
Overview
Manufacturing
Site
Product Profile
Projects
International
Presence
Trade Shows
www.adamfabriwerk.com 32

33. Sterile Processing Projects
www.adamfabriwerk.com 33

34. Sterile Processing Projects
www.adamfabriwerk.com 34

35. Sterile Processing Projects
www.adamfabriwerk.com 35

36. Projects
Reliance Lifesciences Sanofi Aventis
India Egypt
Blood Plasma Products Semi Solids Processing Plant
www.adamfabriwerk.com 36

37. Projects
Serum Institute Of India EIMC
India Egypt
DSP Area Blending Vessels for Vaccine Formulation Vessels
HIB Vaccine Project
www.adamfabriwerk.com 37

38. Projects
Johnson & Johnson Encube Ethicals
India India
Fully Integrated SCADA Controlled Semi Solids-Liquids Fully Automated Semi Solid/Emulsions
Facility Processing Facility
www.adamfabriwerk.com 38

39. Summary Indian Ethos
Company
Overview
Manufacturing
Site
Product Profile
Projects
International
Presence
www.adamfabriwerk.com 39

40. International Presence
Interphex Singapore 2005 CPHI India 2006 Interphex New York 2007
Interphex India 2007 Interphex Philadelphia 2008 Interphex Canada 2008
www.adamfabriwerk.com 40