PAF receptor antagonist inhibited UV-induced skin cancer induction in mice Mice without PAF antagonist developed many tumours Mice with PAF antagonist developed fewer tumours (P<0.001 Mann-Whitney U-test) Ulrich S. (2007); Molecular Carcinogenesis 46: 629-33
Do PAF receptor antagonists inhibit cis-UCA induced immune suppression? YES! And so does the 5-HT receptor antagonist, ketanserin!
Are Cis-UCA and 5-HT structurally similar? YES Do cis-UCA and 5-HT share a receptor? YES Immunoprecipitation Does blocking 5-HT binding inhibits UV/cis-UCA induced immunosuppression? In vivo studies