BrightFocus-Funded Researchers are making an impact. Here's a list of BrightFocus Grantees presenting at ARVO 2014.

1. Sunday, May 4, 2014
8:30 AM - 10:15 AM
Poster Session
Exhibit/Poster Hall SA
BrightFocus-Funded Researcher:
Martin-Paul Agbaga, PhD
University of Oklahoma Health Sciences Center
Differential Composition of Docosahexaenoic Acid and
Very Long Chain Polyunsaturated Fatty Acids in Rod and
Cone Photoreceptor Membranes (370 - C0141)
BrightFocus-Funded Researcher:
Rajendra Apte, MD, PhD
Washington University, School of Medicine
Dysregulation of Macrophage Cholesterol Homeostasis in
AMD Pathogenesis (84 - A0139)
BrightFocus-Funded Researcher:
Neal Peachey, PhD
The Cleveland Clinic Foundation
Retinal Degeneration In CCL2/DAF1 Double-Deficient
Mice (366 - C0137)
BrightFocus-Funded Researcher:
Jiyang Cai, PhD
University of Texas Medical Branch
T Cells Infiltration and RPE Degeneration in NRF2-
deficient Mice Fed with High Fat, Cholesterol-Rich Diet
(75 - A0130)
1:30 PM -­3:15 PM
Poster Session
Exhibit/Poster Hall SA
BrightFocus-Funded Researcher:
Paul A. Knepper, MD, PhD
University of Illinois at Chicago
Primary open-angle glaucoma patients have
superactivated platelets:
A sticky conundrum (531 - A0167)
1:52 PM - 2:09 PM
S 210DE
BrightFocus-Funded Researchers:
Hyungsik Lim, PhD • Hunter College, CUNY
John Danias, MD, PhD • SUNY Downstate Medical Center
Intrinsic Nonlinear Optical Signal in Retinal Nerve Fibers
Sensitive to Microtubule Integrity (129)
BrightFocus-Funded Researchers Presenting at ARVO 2014

2. Monday, May 5, 2014
8:30 AM -­10:15 AM
Poster Session
Exhibit/Poster Hall SA
BrightFocus-Funded Researchers:
Paloma B. Liton, PhD & Molly Walsh, MD
Duke University Eye Center
Ascorbic Acid Modulation of Iron Homeostasis and
Lysosomal Function in Trabecular Meshwork
(5660 - D0153)
BrightFocus-Funded Researcher:
Jason S. Meyer, PhD
Indiana University-Purdue University Indianapolis
Comparison of viral and mRNA-reprogrammed human
induced pluripotent stem cells for retinal differentiation
(1374 - A0130)
Differentiation and Characterization of Retinal Ganglion
Cells Derived from Human Pluripotent Stem Cells
(1375 - A0131)
Epigenetic and Transcriptional Regulation of RAX in
Retinal Fate Determination using Human Induced
Pluripotent Stem Cells (1366 - A0122)
BrightFocus-Funded Researchers:
Curtis Brandt, PhD, FARVO & Paul Kaufman, MD
Board of Regents of the University of Wisconsin System,
School of Medicine and Public Health
Effect of proteasome inhibition on lentiviral vector
transduction in human trabecular meshwork cells and
monkey organ-cultured anterior segments
(5668 - D0161)
BrightFocus-Funded Researchers: Peter Humphries,
PhD; Matthew Campbell, BSc (Hons), PhD & Sarah Doyle,
PhD
Trinity College Dublin
NLRP3 independent mechanisms of RPE cell death
(1318 - A0036)
8:45 AM -­9:00 AM
S 310A-D
BrightFocus-Funded Researcher:
David J. Calkins, PhD
Vanderbilt University Medical Center
Stress-Induced Modulators of Axonopathy in Glaucoma
(1248)
9:15 AM -­9:30 AM
S 310A-D
BrightFocus-Funded Researchers:
Ian Trounce, PhD & Jonathan Guy Crowston, MD, PhD
Centre for Eye Research Australia, The University of
Melbourne
Mitochondrial OXPHOS failure - a burden for long axons
(1250)
11:00 AM -­12:45 PM
Poster Session
Exhibit/Poster Hall SA
BrightFocus-Funded Researcher:
Jonathan Lin, MD, PhD
University of California, San Diego
Endoplasmic Reticulum-Associated Degradation (ERAD)
of Mutant Rod Opsin Disrupts Photoreceptor Protein
Homeostasis During Retinal Degeneration (1742 - A0111)
BrightFocus-Funded Researcher:
Magali Saint-Geniez, PhD
The Schepens Eye Research Institute
PGC-1 alpha regulates human RPE oxidative metabolism
and anti-oxidant capacity (1740 - A0109)
BrightFocus-Funded Researcher:
Zhenhua Xu, PhD & Elia J. Duh, MD
Johns Hopkins University
The neuroprotective role of Nrf2 in ischemia-reperfusion
mouse model (1906 - B0171)
12:15 PM -­12:30 PM
S 230A-D
BrightFocus-Funded Researcher:
Milam A. Brantley, Jr, MD, PhD
Vanderbilt University Medical Center
Metabolic pathways altered in neovascular age-related
macular degeneration (1650)
3:45 PM -­5:30 PM
Poster Session
Exhibit/Poster Hall SA
BrightFocus-Funded Researcher:
Douglas Dean, PhD
University of Louisville Health Sciences Center
Granulocyte Colony Stimulation Factor (G-csf) Blocks
Retinal Gliosis in a Mouse Model of Retinitis Pigmentosa
(2269 - A0173)
BrightFocus-Funded Researchers Presenting at ARVO 2014

3. Tuesday, May 6, 2014
08:30 AM -­10:15 AM
Poster Session
Exhibit/Poster Hall SA
BrightFocus-Funded Researchers:
Arthur Sit, MD & Jay McLaren, PhD
Mayo Clinic College of Medicine
Automated Assessment of Episcleral Venous Pressure
during Venomanometry (2912 - B0310)
BrightFocus-Funded Researcher:
Michael H. Elliott, PhD
University of Oklahoma Health Sciences Center
Role of Caveolin-1 in Intraocular Pressure and
Conventional Outflow Regulation (2888 - B0286)
BrightFocus-Funded Researchers:
Kevin Chan, PhD; Joel Schuman, MD & Ian Conner, MD,
PhD
University of Pittsburgh
Visualization of Aqueous Humor Dynamics upon Chronic
Ocular Hypertension and Hypotensive Drug Treatment
using Gadolinium-Enhanced MRI (2902 - B0300)
9:00 AM -­9:15 AM
S 230A-D
BrightFocus-Funded Researchers:
Kevin Chan, PhD; Joel Schuman, MD & Ian Conner, MD,
PhD
University of Pittsburgh
Structural and Metabolic Correlates of Transsynaptic
Neurodegeneration with Eye Morphology and Visual
Function in Glaucoma (2646)
11:00 AM - 12:45 PM
Poster Session
Exhibit/Poster Hall SA
BrightFocus-Funded Researcher:
Krysten M. Farjo, PhD
University of Oklahoma Health Sciences Center
Over-expression of RBP4 Causes Progressive Retinal
Degeneration in Mice (3478 - D0078)
1:00 PM - 2:30 PM
S 330CD
BrightFocus-Funded Researcher:
Ashwath Jayagopal, PhD
Vanderbilt University Medical Center, Vanderbilt Eye
Institute
In vivo visualization of biomarkers of retinal vascular
disease (360)
3:45 PM -­5:30 PM
Poster Session
Exhibit/Poster Hall SA
BrightFocus-Funded Researcher:
Jason S. Meyer, PhD
Indiana University-Purdue University Indianapolis
Examination of Gap Junction Intercellular
Communication in Human Pluripotent Stem Cell-Derived
Retinal Pigment Epithelium (3998 - D0057)
BrightFocus-Funded Researchers:
Yutao Liu, MD, PhD & Michael Hauser, PhD
Duke University
Variants associated with exfoliation glaucoma affect
promoter activity of the LOXL1 antisense gene
(3816 - B0184)
BrightFocus-Funded Researchers Presenting at ARVO 2014

4. Wednesday, May 7, 2014
08:30 AM -­10:15 AM
Poster Session
Exhibit/Poster Hall SA
BrightFocus-Funded Researcher: Paul A. Knepper, MD, PhD
University of Illinois at Chicago
On the role of intermediate monocyte subtypes in POAG: Possible
cause of disease propagation (4518 - D0192)
Platelet Toll-like receptor 4 expression in POAG: The innate immune
system (4523 - D0197)
9:45 AM - 10:00 AM
S 330EF
BrightFocus-Funded Researcher: Lee Goldstein, MD, PhD
Brigham & Women’s Hospital
alphaB-Crystallin Modulates Amyloid-beta; toxicity and impairs
Synaptic Transmission (4055)
11:00 AM -­12:45 AM
Poster Session
Exhibit/Poster Hall SA
BrightFocus-Funded Researcher: Paul A. Knepper, MD, PhD
University of Illinois at Chicago
Nailfold hemorrhages and dilated capillaries separate POAG from
NTG (4751 - B0112)
BrightFocus-Funded Researchers: Kevin Chan, PhD; Joel Schuman,
MD & Ian Conner, MD, PhD
University of Pittsburgh
Neurophysiology of Occipital Cortex Deterioration and its
Relationships to Clinical Ophthalmic Measures in Glaucoma
(4771 - B0132)
BrightFocus-Funded Researcher: Wei Li, PhD
University of Miami, Miller School of Medicine
Systematic identification of diabetic retinopathy-associated
endothelial ligands (4920 - C0235)
12:15 PM - 12:30 PM
S 310E-H
BrightFocus-Funded Researcher: Aparna Lakkaraju, PhD
Board of Regents of the University of Wisconsin System
Live imaging reveals multiple regulators of canonical autophagy in
the retinal pigment epithelium (4564)
12:30 PM - 12:45 PM
S 310E-H
BrightFocus-Funded Researcher: Jonathan Lin, MD, PhD
University of California, San Diego
IRE1 Signaling and ER Stress Levels Increase With Age in Retina (4565)
3:45 PM -­5:30 PM
Poster Session
Exhibit/Poster Hall SA
BrightFocus-Funded Researcher: Jing Chen, PhD
Boston Children’s Hospital
Endothelial miR-150 regulates pathologic retinal vascular growth in a
mouse model of retinopathy of prematurity (5391 - D0023)
Over-expression of sirtuins does not protect against retinal
neovascularization in a mouse model of oxygen-induced retinopathy
(5399 - D0031)
Twist1 Regulates Pathologic Neovascularization in Retinopathy
(5382 - D0014)
4:00 PM - 4:15 PM
S 320GH
BrightFocus-Funded Researcher: Raquel Lieberman, PhD
Georgia Institute of Technology
Crystal structure of the olfactomedin domain of myocilin (5031)
5:10 PM - 5:27 PM
S 310E-H
BrightFocus-Funded Researcher: Thomas A. Ferguson, PhD
Washington University
Non-canonical autophagy promotes the visual cycle (5029)
Thursday, May 8, 2014
08:30 AM -­10:15 AM
Poster Session
Exhibit/Poster Hall SA
BrightFocus-Funded Researchers:
Ian Trounce, PhD & Jonathan Guy Crowston, MD, PhD
Centre for Eye Research Australia, The University of Melbourne
Amyloid precursor protein protects against a rodent model of optic
neuropathy and is abundant in the human vitreous (5732 - B0040)
BrightFocus-Funded Researcher:
Ashwath Jayagopal, PhD
Vanderbilt University Medical Center, Vanderbilt Eye Institute
Imaging of Retinal Vascular Disease Using Hypoxia-Sensitive Contrast
Agents (5873 - C0059)
BrightFocus-Funded Researcher:
Susanne Ragg, MD, PhD
Indiana University School of Medicine
Quantitative protein-antibody array analysis of aqueous humor In
glaucoma and cataract (5708 - B0016)
BrightFocus-Funded Researchers:
Kevin Chan, PhD; Joel Schuman, MD & Ian Conner, MD, PhD
University of Pittsburgh
Relationships between Anterior Visual Pathway Morphology, Ocular
Physiology and Visual Function in Glaucoma (5847 - C0033)
08:50 AM -­09:10 AM
Hall SB
BrightFocus-Funded Researchers:
Gaofeng Wang, PhD & Sander Dubovy, MD
University of Miami Miller School of Medicine
Links between ARMS2 genotype, gene expression, and potential roles
in AMD (5422)
9:15 AM - 9:30 AM
S 230A-D
BrightFocus-Funded Researchers:
Gerard Lutty, PhD & Imran Bhutto, MD, PhD
Johns Hopkins University
Death of choriocapillaris in age-related macular degeneration (5417)
BrightFocus-Funded Researchers Presenting at ARVO 2014