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Cancer slides2013
Cancer slides2013
Cancer slides2013
Cancer slides2013
Cancer slides2013
Cancer slides2013
Cancer slides2013
Cancer slides2013
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Cancer slides2013

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  • 1.  10-3 Regulating the Cell Cycle Cyclins are proteins that regulate the cell cycle – “Tell” cell when to divide, enter cell cycle phases – Signal spindle formation during Interphase – In addition to cyclins, other proteins also help regulate cycle Internal regulators respond to events inside a cell - check that a cell is prepared for mitosis – spindle fibers, replicated DNA, etc. External regulators are outside signals to speed up/slow down cell division – ie: contact inhibition, wound healing
  • 2. Contact Inhibition Most cells will keep dividing until they come in contact with other cells
  • 3. What is Cancer? Result of faulty cell cycle – Cells lose ability to control growth – do not respond to regulatory signals – Cells divide out of control – do not spot dividing when come in contact with other cells like normal cells do – Demonstrate bizarre behavior
  • 4. What is Cancer? Malignant tumor – Lump resulting from division of cancer cell • Can spread • Displaces normal tissue • Can spread into circulatory system Metastasis – Spread of malignant cells to other tissues Cancers named for where they originate • Non-metastatic, noninvasive tumors are called benign
  • 5. What causes Cancer? Causes of cancer – Carcinogens – cancer causing chemicals (tobacco, asbestos) – Mutations in DNA overproduce growth factors (cells keep dividing) OR do not produce suppressors (cells never stop dividing) - a defect in p53 gene – Some viruses – Heredity - genes – Radiation
  • 6. Symptoms/Treatments Symptoms vary – Unexplained weight change – Lumps or growths – Abnormal bleeding Treatment – Prevention! (diet, lifestyle, self-examinations) – Surgery/Radiation/Chemotheraphy
  • 7. Cancer Treatments GOAL: Stop cells from dividing! – Surgery – remove the cells/tumor – Radiation • High energy radiation disrupts cell division – Chemotherapy • Drugs that disrupt cell division • Anti-mitotic drugs (taxol, vinblastine)

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