Regulating the Cell Cycle

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miller biology book section 10.3

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Regulating the Cell Cycle

  1. 1. Regulating the Cell Cycle miller 10.3
  2. 2. Controls on Cell Division <ul><ul><li>How is the cell cycle regulated? </li></ul></ul>
  3. 3. Controls on Cell Division <ul><ul><li>How is the cell cycle regulated? </li></ul></ul><ul><ul><ul><li>by regulatory proteins both inside and outside the cell </li></ul></ul></ul>
  4. 4. Controls on Cell Division <ul><ul><li>How is the cell cycle regulated? </li></ul></ul><ul><ul><ul><li>by regulatory proteins both inside and outside the cell. </li></ul></ul></ul><ul><ul><ul><ul><li>these chemicals can turn cell growth signals on or off </li></ul></ul></ul></ul>
  5. 5. Cyclins <ul><ul><li>Cyclins = type of proteins that regulate the timing of the cell cycle in eukaryotic cells. </li></ul></ul>Interpret this graph
  6. 6. When might cell growth need to be stimulated?
  7. 7. <ul><ul><li>an injury can stimulate cell growth to heal the damage </li></ul></ul>When might cell growth need to be stimulated?
  8. 8. Cancer: Uncontrolled Cell Growth <ul><ul><li>How do cancer cells differ from other cells? </li></ul></ul>
  9. 9. Cancer: Uncontrolled Cell Growth <ul><ul><li>How do cancer cells differ from other cells? </li></ul></ul><ul><ul><ul><ul><li> </li></ul></ul></ul></ul><ul><ul><ul><ul><li> ✓ do not respond to signals that regulate growth of most cells </li></ul></ul></ul></ul>
  10. 10. Cancer: Uncontrolled Cell Growth <ul><ul><li>How do cancer cells differ from other cells? </li></ul></ul><ul><ul><ul><ul><li> </li></ul></ul></ul></ul><ul><ul><ul><ul><li> ✓ do not respond to signals that regulate growth of most cells </li></ul></ul></ul></ul>don’t respond to chemical signals don’t respond to contact inhibition
  11. 11. Cancer: Uncontrolled Cell Growth <ul><ul><li>How do cancer cells differ from other cells? </li></ul></ul><ul><ul><ul><ul><li> </li></ul></ul></ul></ul><ul><ul><ul><ul><li> ✓ do not respond to signals that regulate growth of most cells </li></ul></ul></ul></ul><ul><ul><ul><ul><li>✓ grow into tumors </li></ul></ul></ul></ul>don’t respond to chemical signals don’t respond to contact inhibition
  12. 12. Contact Inhibition
  13. 14. Tumors <ul><ul><li>A benign tumor is noncancerous. It does not spread to surrounding healthy tissue. </li></ul></ul><ul><ul><li>A malignant tumor is cancerous. </li></ul></ul>
  14. 15. <ul><ul><li>A benign tumor is noncancerous. It does not spread to surrounding healthy tissue. </li></ul></ul><ul><ul><li>A malignant tumor is cancerous: </li></ul></ul><ul><ul><li>invades and destroys surrounding healthy tissue </li></ul></ul>
  15. 16. <ul><ul><li>A benign tumor is noncancerous. It does not spread to surrounding healthy tissue. </li></ul></ul><ul><ul><li>A malignant tumor is cancerous: </li></ul></ul><ul><ul><li>invades and destroys surrounding healthy tissue </li></ul></ul><ul><ul><li>can spread to other parts of the body (called metastasis) </li></ul></ul>
  16. 17. <ul><ul><li>A benign tumor is noncancerous. It does not spread to surrounding healthy tissue. </li></ul></ul><ul><ul><li>A malignant tumor is cancerous: </li></ul></ul><ul><ul><li>invades and destroys surrounding healthy tissue </li></ul></ul><ul><ul><li>can spread to other parts of the body (called metastasis. </li></ul></ul><ul><ul><li>cancer cells absorb nutrients needed by other cells, block nerve connections, and prevent organs from functioning </li></ul></ul>
  17. 20. What Causes Cancer? <ul><ul><li>Cancers are caused by defects in genes that regulate cell growth and division. </li></ul></ul>
  18. 21. What Causes Cancer? <ul><ul><li>Cancers are caused by defects in genes that regulate cell growth and division. </li></ul></ul><ul><ul><ul><li>gene called “p53” is commonly involved </li></ul></ul></ul>
  19. 22. What Causes Cancer? <ul><ul><li>Cancers are caused by defects in genes that regulate cell growth and division. </li></ul></ul><ul><ul><ul><li>gene called “p53” is commonly involved </li></ul></ul></ul><ul><ul><ul><li>exposure to certain chemicals (from smoking, radiation, viruses for example) can damage genes </li></ul></ul></ul>
  20. 23. <ul><ul><li>end of part 1 </li></ul></ul>

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