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juancarlosrise

Health & Medicine Technology

Juan Carlos Torres Sánchez 804-11-9230 BIOL 3095 5/18/2012

Seminar 1 on Stem Cells, Discussing the Seminar Presentation

On September 26 and 27, we had a seminar with Jessian Muñoz, a college graduate

student fromNew Jersey Medical School. This experience has opened my mind in

relation to a new aspect of science I did not know quite well, cancer stem cells. How

could cancer stem cells be the primary cause of brain tumors? That question was well

answered by our seminar person of this week, Mr. Jessian Muñoz. Due to his

knowledge, we learned about brain tumors, what the starting point is,and about a new

topic, the microRNA. The microRNA was discovered in the human genome project,

whichdemonstrates how science discoveries have made lots of great advances in

benefits of health care. Dysfunction in microRNA signaling is present in all cancers

that have been studied thus far.

There was also the discussion about cancer stem cells (CSC). Cancer stem cells are

the of brain tumors. The problem that we had before was that with chemotherapy, the

cells that were targeted were the ones around the cancer stem cells so the cancer

would normally spread again. What they are trying to do is to suppress the pathway of

the stem cells so that stem cells will become responsive to chemo and radiotherapy.

They are encountering problems with this procedure also as cancer stem cells are

reappearing after therapy. Finding these cancer stem cells implies that this could be

the cure for cancer. Also, stem cells could be applied to different studies, for example

new knowledge has been provided that giving stem cells to a person with diabetes

could help regenerate their pancreatic beta cells.

Jessian’slifelong goals changed during the course of his studies, he went from

wanting to be a pedriatitian to studying a PhD. This demonstrates how it doesn’t

matter how long it will takeor if I change my goals, as long as I persevere it will be all

worth it at the end. I recommendthese types of seminars to anyone who wants to be

more knowledgeable on exciting topics.

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In situ genetic technology was historically developed and mainly focused on detection purpose, allowing specific nucleic acid sequences to be visualized in morphologically preserved tissue sections. With the synergy of genetics and immunohistochemistry, in situ detection can correlate microscopic topological information with gene activity at the transcriptional or post-transcriptional levels in specific tissues. Furthermore, its resolution allows spatial distribution of nucleic acid products to be revealed in a heterogeneous cell population. The newest member to the franchise of in situ genetic technology is a direct-on-specimen enrichment methodology specifically for cell-free DNA liquid biopsy. Contrary to in situ detection, this in-well in situ innovation tackles the very first sample preparation step to reduce material loss, thereby improving overall sensitivity. Genomic nucleic acids purified from specimens have been proven to be time consuming and suffered from damages and losses; the evolution of in situ genetic technology offers a powerful tool for precision functional genomics, enabling cross-check between in vitro and in vivo findings. It further opens the door to ultimate genetic engineering in situ.

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Background: Among the many limitations of cancer control in Nigeria are lower awareness/competence and poorer training of health-care professionals (HCP). These manifest as deficiencies in advocacy, screening/diagnostic practices, and patient management. Medical simulation (MS) using models is an effective approach for sustainably improving the competence of HCP, especially regarding clinical breast examination (CBE), pelvic examination (PE), and digital rectal examination (DRE). The study evaluates the effect of MS during a Nigerian training course focusing on CBE, PE, and DRE. It answers the question: What is the immediate outcome of MS-based training, as well as the perspectives of HCP on the use of MS for cancer education? Methods: Participants included a convenience sample of Nigerian physicians and nurses who attended the American Society of Clinical Oncology-sponsored Multidisciplinary Cancer Management Course. The intervention was MS using high-fidelity models. The models demonstrated normal anatomic and common pathologic features of the breast, cervical, and prostate. Participants cycled through MS stations (i.e., CBE, PE, and DRE). Pre- and post-training surveys with comments evaluating self-reported comfort levels were the basis for comparison. Data analysis included descriptive statistics, Wilcoxon signed-rank test, Chi-square, and thematic analysis. Results: A total of 51 participants completed course evaluation forms (physicians - 35 and nurses - 16), with an average number of years in practice as 8 (±5.2) years. Pre-training survey showed non-significant differences in practices patterns; 71% (22/35) of physicians rarely performed PE (P=0.92), and 93% (14/16) of nurses rarely performed DRE (P=0.07). According to some participants, “the use of simulation is quite commendable as it gives room for improvement before using a human; it is the best method of learning I have ever enjoyed.” Conclusion: MS-based training significantly improved the comfort levels of participants regarding CBE and PE, as well as their likelihood to perform CBE, PE, and DRE. Participants recommend widespread use of MS for continuing medical education and undergraduate training.

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The Opposing Viewpoint of Stem Cell Stem cell research explores the nature and growth capabilities of cells essential for ensuring replacement of cells in living organisms (Paddock, 2017). Such cells have an advantage of being manipulated to any type of cells as it is deemed necessary by the scientists based on scarcity or slow rejuvenation process of the natural cells. The general public has largely adopted a reserved approach to stem cell research and therapy despite the positive research and development showcased by leading scientists including; · Jun Takahashi: he explored the safety and applicability of stem cell therapy in primates in relations to the Parkinson’s disease, recording a major success between the interaction of human cells and animals (Sandoiu). Furthermore, no long-term negative effect was established from the treatment that saw full recovery of the primates. · Hai Nguyen, Aileen Anderson and colleagues: carried a similar exercise on injured mice to record tremendous success of the donor cells in a period ranging immediately after the induction process to at most one month (Society for Neuroscience. 2017). · Scientists from the Cedars-Sinai Heart Institute in Los Angeles CA: highlighted the need for stem therapy in replacing aging heart muscles using rats (Paddock, 2017). The induced cells were able to grow and multiply thus repair the heart muscles of the older rats to improve the general body functioning. Despite the breathtaking discoveries as tested and presented by these scientists, ethical concerns have prevailed to the dismay of an excited global scientists’ fraternity. The general public is cautious in its approach to stem cell therapy from various reasons ranging from the potential to cause cancer to how the media overrates the treatment process that still has critical gaps to full implementation (Begley, 2017). There are two major concerns that arise from the Cedars-Sinai Heart Institute research as reported by Paddock. The first concern as perceived by the layman defined as the general public is the fact the findings are based on animals other than human beings. This experiment was purely run on rodent tissue thus raising a legitimate query as to the consistency if replicated in humans. The second concern arises from Paddocks admission that the scientists proposed the need for further research to determine whether the findings are only valid when the donors are young (2017). Since the same article admits the fact modern day medicine has seen prolonged life with a possibility of the elderly to exceed the children population, such a dependency on young donors may endanger the human species in the long run. The excitement surrounding Stem Cell Research is magnified through mainstream media that often cares about moving volumes in sales rather than realistically highlight the caution or reservations pronounced by scientists. However, Sharon Begley is exemplary in her revelation of a high-risk gap in research that li ...

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