Biblio 3 official

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Biblio 3 official

  1. 1. Juan Carlos Torres Sánchez #804-11-9230 BIOL 3095Wilson ME, Boumaza I, Lacomis D and Bowser R. Cystatin C: A CandidateBiomarker for Amyotrophic Lateral Sclerosis. 2010. Plos One. 5(12):e15133.Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease that affects themotor neurons almost always leading to death. New ways to early detection andprevention are underway. An approach can be the biomarker discovery. The objectiveof this researchis to use the quantitative technique of ELISA to evaluate the utility ofcystain C as a possible biomarker for ALS in a large subject population. The resultsdemonstrated that cystain C concentration decreased in cerebral spinal fluid (CSF)while higher in plasma concentration of ALS patients compared to the healthy ones.Also, CSF cystain C concentration has a prognostic utility in estimating patientsurvival time. The high and low concentration and estimation of survival of patientsshows that cystain C may have a potential neuroprotective role of this protein in thepathobiology of ALS. This research is very useful because it demonstrates a stepforward towards getting this biomarker to the market because the scientist found thisspecific biomarker that could be of great use for this disease.

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