Juan Carlos Torres Sánchez #804-11-9230 BIOL 3095Ranganathan S, Williams E, Ganchev P, Gopalakrishnan V, Lacomis D, Urbinelli à L,Newhall K, Cudkowicz ME, Brown Jr. RH and Bowser R. 2005. Proteomic profilingof cerebrospinal fluid identifies biomarkers for amyotrophic lateral sclerosis. Journalof Neurochemestry. 95:1461–1471This review is about Amyotrophic Lateral Sclerosis (ALS) and profiling biomarkersfor this disease. ALS is a neurodegenerative disease that causes damage to motorneurons located in the cerebral cortex, brainstem and spinal cord. To help detectspecific biomarkers in this research,they used cerebrospinal fluid (CSF) from ALSpatients and from the control subjects using surface-enhanced laser desorption/ionization-time of flight mass spectrometry (SELDI-TOF-MS). This technique hasbetter precision in identifying biomarkers. Three biomarkers were found in the results,transthyretin, cystatin C, and carboxy-terminal fragment of neuroendocrine protein7B2. Two of these biomarkers were validated, showing a section of CSF biomarkersof ALS patients. This study is very useful because it displays the correlation of howimportant it is to find biomarkers for ALS patients and how cystain C can be a greatbiomarker for that disease.