BIOL 3095 September 2, 2011. Seminar Reflection #1: “Cancer stem cells in the brain tumors”. By: Angélica M. González Sánchez Student number: 804-11-3354 On Thursday, August 25, 2011 I attended a seminar given by the MD/PhD student Mr.Jessian Muñoz on which he presented us numerous topics from his expertise areas. First of all,he talked about his university: New Jersey Medical School. Then, he started off explainingseveral concepts of the main topic, which was the detection of stem cells in glioblastomamultiforme (GBM), the most common and aggressive tumor of the brain. Initially, the speakerexplained us all about stem cells and about the brain’s structure. He told us that, in the brain, asin any other organ, there are stem cells and there’s also the probability of development oftumors, such as glioblastoma multiforme. It has been found that there are about 0.2% of stem-like cells in these tumors, which are radio and chemo resistant and have special pathways whichlead to their long survival. These “cancer stem cells” are probably responsible for metastasis andfor the reappearance of brain tumors. The studies on this subject have mostly been done in vitrowith human brain tumors or with mouse models. These studies are important because they willallow targeting cancer stem cells and can improve treatment for GBM by stopping the specificcancer stem cells pathways. This will either kill these cells or turn them into normal cells whichare susceptible to radio and chemotherapy. In my opinion, this seminar was very didactic because it taught me a lot of new conceptsand helped me to understand them deeply. I would recommend it because it encourages researchby showing its scope and importance in the development of science.