Renal pathology

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  • In Minimal and FSGN  effacement of foot processes
  • Diffuse thickening of GBM…with sub epithelial deposits
  • MPGN  lobular appearance due to the proliferation of mesangeal and endothelial cells
  • MPGN Type 1  sub endo
  • Type 1 – irregular granular pattern
  • MPGN  intra membranous 
  • Mesangial rings  type 2
  • Post strept
  • Post strept
  • Post strept -  scattered Granular deposits
  • An intense IgA deposition in the mesangial stalk is more common.
  • Proliferation of the parietal epithelial cells and infiltration by monocytes and macrophages
  • Linear deposits of Ig G
  • Granular pattern of staining
  • Clear cell
  • Papillary
  • Chromophobe
  • Collecting duct
  • Renal pathology

    1. 1. Renal pathology
    2. 2. Nephrotic Syndrome
    3. 4. Primary glomerular diseases <ul><li>Minimal change disease / Lipoid nephrosis </li></ul><ul><li>Focal Segmental Glomerulosclerosis </li></ul><ul><li>Membranous Nephropathy /MGN </li></ul><ul><li>MPGN </li></ul>
    4. 5. Minimal change disease / Lipoid nephrosis <ul><li>Normal in light microscopy </li></ul><ul><li>Electron  diffuse effacement of podocyte foot processes </li></ul>
    5. 10. Membranous Glomerulonephritis
    6. 12. MPGN
    7. 17. Nephritic Syndrome <ul><li>Acute Post infectious GN </li></ul><ul><li>IgA Nephropathy </li></ul><ul><li>Heriditary nephritis </li></ul>
    8. 18. Post streptococcal GN
    9. 21. Ig A Nephropathy <ul><li>Usually affects children and young adults </li></ul><ul><li>1 or 2 days after a non specific upper respiratory tract infection </li></ul><ul><li>Deposition of Ig A in the mesangium is the hallmark of the disease </li></ul>
    10. 23. Histo <ul><li>Variable </li></ul><ul><li>FP </li></ul><ul><li>MP </li></ul><ul><li>Crescentic Gn </li></ul>
    11. 24. RPGN/ Crescentic <ul><li>Clinical syndrome </li></ul><ul><li>Not a specific etiological form of GN </li></ul>
    12. 26. Types <ul><li>Type 1  Anti GBM antibody  Good Pasture Syndrome </li></ul><ul><li>Type 2  Immune complex  Post infectious , SLE , IgA nephropathy </li></ul><ul><li>Type 3  Pauci immune – ANCA associated-----Wegener’s Granulomatosis , Microscopic angitis </li></ul>
    13. 27. Type 1
    14. 28. Type 2
    15. 30. Renal Cell Carcinoma <ul><li>Clear cell carcinoma </li></ul><ul><li>Papillary carcinoma </li></ul><ul><li>Chromophobe carcinoma </li></ul><ul><li>Collecting Duct carcinoma </li></ul>

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