The eicosanoids are a group of signaling
sub-stances that arise from the C-20 fatty
acid arachidonic acid and therefore usually
contain 20 C atom (Greek eicosa=20). As
mediators, they influence a large number of
Eicosanoids (20 carbons) are found in the animal
kingdom and a variety of plants.
The eicosanoids are oxygenation products of
acid arachidonic (AA) polyunsaturated fatty
Acid arachidonic is released from membrane by
phospholipase A2 (PLA2).
Prostaglandins & Leukotrienes
Local hormones - very active,many functions..
Autacoids from 20 C PUFA