Forensic medicine medical negligence 2-bolam principle
Microbiology lec2
1. Medical Microbiology Lecture 2 Dr. Saleh M Y OTH PhD Medical Molecular Biotechnology and Infectious Diseases 02/10/2010 IMS - MSU
2. Infection: The growth of microorganisms in the host without causing damages to the host. Definaations Bacteria may be divided into three types based on their potential to cause diseases; - pathogens , - commensals , and - nonpathogens . Must to know: Morbidity, mortality, infections, parasite, host, vector, fomite, contagious (infectious) disease, epidemic, endemic, pandemic, Zoonosis, Epizootic, Attack rate.
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6. Some tissues, organs are dense with normal flora, others are normally sterile a. colonized sites i. alimentary/intestinal tract ii. upper respiratory tract iii. distal genitourinary tract iv. skin b. normally sterile sites i. blood ii. CSF iii. interstitial fluid and spaces iv. lymph
7. Disease ; damage caused by presence of microorganisms or their products. Colonization - presence of microorganisms without disease at that point. This term applies to surfaces only , i.e., the blood cannot be colonized and host cells with intracellular infection are not colonized.
8. Carrier state; colonization with a pathogen Pathogen ; any organism that has the potential to cause disease
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11. Pili and Afimbrial Adhesins Pili - fimbrial Adhesins Afimbrial Adhesins (No pili) Adherence and colonization ……..
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19. Mechanisms of Bacterial Pathogenesis Virulence factors are bacterial strategies or products which contribute to each of these steps leading ultimately
20. Functions and stages of pathogens and disease 1. encounter 2. entry 3. spread (+/-) 4. multiplication 5. evasion of host defenses 6. damage 7. outcome a. transmission to new host (+/-) b. recovery or not
