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Knowing what works in Health Care: A roadmap for the nation IOM Committee on Reviewing Evidence to Identify Highly Effective Clinical Services January 2008
Committee Charge: To recommend ,[object Object],[object Object],[object Object]
-Evidence-Based Practice Centers -Proprietary firms Systematic review ,[object Object],[object Object],[object Object],[object Object],Body of  evidence ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Strengths of the system ,[object Object],[object Object],[object Object],[object Object]
The problems ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Policy in the US ,[object Object],[object Object],[object Object],[object Object],[object Object]
Comparative clinical effectiveness research ,[object Object],[object Object],[object Object],[object Object],[object Object]
IOM committee charge ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],IOM report
The Committee’s recommendations
Recommendation: high level ,[object Object],[object Object],[object Object],[object Object]
Setting priorities The Program Systematic review ,[object Object],[object Object],[object Object],[object Object]
Recommendation: high level ,[object Object],[object Object],[object Object],[object Object]
Setting priorities The Program Systematic review ,[object Object],[object Object],[object Object],[object Object]
Recommendation: setting priorities ,[object Object],[object Object]
Recommendation: setting priorities ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Setting priorities The Program Systematic review ,[object Object],[object Object],[object Object],[object Object]
Problems with systematic reviews: the IOM committee’s view ,[object Object],[object Object],[object Object],[object Object],[object Object]
Assessing Evidence: recommendations ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Developing Practice Guidelines:  Recommendations
Done by the Program Systematic review ,[object Object],[object Object],[object Object],[object Object],Setting priorities
Hybrid vs. Agency Model ,[object Object],[object Object],PS SR GL production PS SR GL production
Hybrid vs. Agency Model ,[object Object],[object Object],PS SR GL production PS SR GL production
Done by the Program Done  By  Existing Entities Systematic review ,[object Object],[object Object],[object Object],[object Object],Setting priorities
Rationale for the hybrid model ,[object Object],[object Object],[object Object],[object Object]
Won’t the hybrid model simply perpetuate the chaotic system we have now?
Won’t the hybrid model simply perpetuate the chaotic system we have now? Not  if all guideline producers adhere to The Program’s standards for  process  and  language  for rating the strength of the evidence and recommendations.
Tie their credibility to adherence to standards of good practice How to motivate guideline developers to adhere??
Recommendations: developing guidelines ,[object Object],[object Object]
Challenges for The Program ,[object Object],[object Object],[object Object],[object Object],[object Object]
The IOM Committee’s recommendations about  priority-setting
Getting nominations Source: IOM report “What works….”, 2008 anyone NHS NICE Anyone CMS website MCAC Anyone Varies Cochrane BCBSA people BCBSA people BCBSA Anyone Federal Register + stakeholders AHRQ & USPSTF Who can nominate? Solicitation Organ-ization
Topic nominations received by AHRQ (2005 and 2006) Source: IOM report “What works….”, 2008 47 Total  8 Other 16 Professional Societies 3 Health Plans 20 Federal Agencies Number Source
AHRQ: Categories of Topics Nominated Source: IOM report “What works….”, 2008 5 Other 8 QI and patient safety 6 Organization and Finance 1 Rehabilitation 36 Treatment 13 Diagnosis 7 Prevention Number Category
Priority-setting Criteria Source: IOM report “What works….”, 2008 X X Variation X X x X New Evidence X X x X Controversy X X X x X Impact X X X X Burden X X Cost USPSTF NICE OMAR BC-BSA AHRQ
The IOM committee’s conclusions ,[object Object],[object Object],[object Object],[object Object],[object Object]
The IOM committee’s conclusions (cont.) ,[object Object],[object Object],[object Object],[object Object]
The IOM committee recommendations ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Principles to guide priority setting process ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
The IOM committee’s two paramount criteria ,[object Object],[object Object]
Two Examples of Priority-setting ,[object Object],[object Object]
IOM committee to recommend a priority setting process (1992) ,[object Object],[object Object],[object Object]
W = the weight for a criterion S  = the score for the criterion Source: IOM Committee on Priority Setting, 1992 Priority Score =  Σ   W n  x lnS n
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Priority Score =  Σ   W n  x lnS n
Staff Calculate priority score and rank order Model Assign a score to each criterion Staff + panel Obtain data for each criterion Panel  Winnow the list Staff  Solicit nominations of candidate technologies Panel Choose criteria and assign weights Priority Score =  Σ   W n  x lnS n
0 1 0.69 2.0 1.0 Δ ELS 1.04 2 2.08 4.0 1.5 Δ  cost 2.62 3.7 2.33 3.2 2.0 Δ outco -2.13 0.17 -1.23 0.36 1.2 Var 11.24 1,800 13.66 9000 1.5 Cost 1.19 1.7 3.28 4.3 2.3 Burden 7.37 100 5.44 30 1.6 Prev W*lnS Score(S n ) W*lnS Score (S n ) W n =cardiac condition = acute surgery
Priority Score =  Σ  W n  x lnS n 0 1 0.69 2.0 1.0 Δ ELS 1.04 2 2.08 4.0 1.5 Δ  cost 2.62 3.7 2.33 3.2 2.0 Δ outco -2.13 0.17 -1.23 0.36 1.2 Var 11.24 1,800 13.66 9000 1.5 Cost 1.19 1.7 3.28 4.3 2.25 Burden 7.37 100 5.44 30 1.6 Prev W*lnS Score(S n ) W*lnS Score (S n ) W n =cardiac condition = acute surgery =26.25 =21.34
Priority setting for AHRQ’s Clinical Effectiveness Review Program ,[object Object],[object Object],[object Object]
AHRQ’s five priority-setting criteria ,[object Object],[object Object],[object Object],[object Object],[object Object],Source: Jean Slutsky, personal communication

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Plenary Day 1 Speaker 1 Hal Sox

  • 1. Knowing what works in Health Care: A roadmap for the nation IOM Committee on Reviewing Evidence to Identify Highly Effective Clinical Services January 2008
  • 2.
  • 3.
  • 4.
  • 5.
  • 6.
  • 7.
  • 8.
  • 10.
  • 11.
  • 12.
  • 13.
  • 14.
  • 15.
  • 16.
  • 17.
  • 18.
  • 20.
  • 21.
  • 22.
  • 23.
  • 24.
  • 25. Won’t the hybrid model simply perpetuate the chaotic system we have now?
  • 26. Won’t the hybrid model simply perpetuate the chaotic system we have now? Not if all guideline producers adhere to The Program’s standards for process and language for rating the strength of the evidence and recommendations.
  • 27. Tie their credibility to adherence to standards of good practice How to motivate guideline developers to adhere??
  • 28.
  • 29.
  • 30. The IOM Committee’s recommendations about priority-setting
  • 31. Getting nominations Source: IOM report “What works….”, 2008 anyone NHS NICE Anyone CMS website MCAC Anyone Varies Cochrane BCBSA people BCBSA people BCBSA Anyone Federal Register + stakeholders AHRQ & USPSTF Who can nominate? Solicitation Organ-ization
  • 32. Topic nominations received by AHRQ (2005 and 2006) Source: IOM report “What works….”, 2008 47 Total 8 Other 16 Professional Societies 3 Health Plans 20 Federal Agencies Number Source
  • 33. AHRQ: Categories of Topics Nominated Source: IOM report “What works….”, 2008 5 Other 8 QI and patient safety 6 Organization and Finance 1 Rehabilitation 36 Treatment 13 Diagnosis 7 Prevention Number Category
  • 34. Priority-setting Criteria Source: IOM report “What works….”, 2008 X X Variation X X x X New Evidence X X x X Controversy X X X x X Impact X X X X Burden X X Cost USPSTF NICE OMAR BC-BSA AHRQ
  • 35.
  • 36.
  • 37.
  • 38.
  • 39.
  • 40.
  • 41.
  • 42. W = the weight for a criterion S = the score for the criterion Source: IOM Committee on Priority Setting, 1992 Priority Score = Σ W n x lnS n
  • 43.
  • 44. Staff Calculate priority score and rank order Model Assign a score to each criterion Staff + panel Obtain data for each criterion Panel Winnow the list Staff Solicit nominations of candidate technologies Panel Choose criteria and assign weights Priority Score = Σ W n x lnS n
  • 45. 0 1 0.69 2.0 1.0 Δ ELS 1.04 2 2.08 4.0 1.5 Δ cost 2.62 3.7 2.33 3.2 2.0 Δ outco -2.13 0.17 -1.23 0.36 1.2 Var 11.24 1,800 13.66 9000 1.5 Cost 1.19 1.7 3.28 4.3 2.3 Burden 7.37 100 5.44 30 1.6 Prev W*lnS Score(S n ) W*lnS Score (S n ) W n =cardiac condition = acute surgery
  • 46. Priority Score = Σ W n x lnS n 0 1 0.69 2.0 1.0 Δ ELS 1.04 2 2.08 4.0 1.5 Δ cost 2.62 3.7 2.33 3.2 2.0 Δ outco -2.13 0.17 -1.23 0.36 1.2 Var 11.24 1,800 13.66 9000 1.5 Cost 1.19 1.7 3.28 4.3 2.25 Burden 7.37 100 5.44 30 1.6 Prev W*lnS Score(S n ) W*lnS Score (S n ) W n =cardiac condition = acute surgery =26.25 =21.34
  • 47.
  • 48.