WHO Italian CME course an antibiotic stewardship
• Understand the frequent occurrence and implications of
contaminated urine cultures and of asymptomatic bacteriuria
• Illustrate the complexity of using urinalysis and urine culture to
support the diagnosis of urinary tract infections
• Demonstrate the use of local evidence-based guidelines based
upon local antimicrobial resistance data in managing urinary tract infections
3. "The thoughtless person playing with
penicillin treatment is morally
responsible for the death of the man
who succumbs to infection with the
penicillin-resistant organism.”
Sir Alexander
Fleming
Nobel prize winner
for the discovery of
penicillin, 1945
3
4. Core competencies for
antimicrobial prescribing
C1: Understands the patient and the patient’s clinical needs
C2: Understands treatment options and how they support the
patient’s clinical needs
C3: Works in partnership with the patient and other healthcare
professionals to develop and implement a treatment plan
C4: Communicates the treatment plan and its rationale clearly to
the patient and other health professionals
C5: Monitors and reviews the patient’s response to treatment
4
Core Competencies
5. Objectives
• Understand the frequent occurrence and implications of
contaminated urine cultures and of asymptomatic bacteriuria
• Illustrate the complexity of using urinalysis and urine culture to
support the diagnosis of urinary tract infections
• Demonstrate the use of local evidence-based guidelines based
upon local antimicrobial resistance data in managing urinary tract
infections
5
6. Positive urine cultures could be due to:
Contaminated culture
Asymptomatic bacteriuria
Urinary tract infection (UTI)
6
WHO/A. Kristensen
11. 45 year-old female with:
a positive urine culture 3 weeks ago
urine culture performed because of
dysuria & urinary frequency
now asymptomatic
normal physical exam
11
13. Obtain urine culture only when you
suspect UTI
• Contaminated urine
cultures and
asymptomatic
bacteriuria (ASB) are
common
13
WHO/O. Karatuna
14. Urinalysis interpretation
• high numbers of
squamous epithelial cells
suggests specimen
contamination
• absence of pyuria
provides reassurance
against a UTI
14
WHO/O. Karatuna
15. Asymptomatic bacteriuria (ASB)
• Limited indications for ASB treatment
– Pregnancy
– Invasive urologic procedure
• Test of cure cultures should NOT be performed
15
17. Review the microbiologic data
• The presence of 3
organisms suggests a
contaminated
specimen.
• Was it necessary?
17
WHO/O. Karatuna
18. Clinical case 1
Should she submit another sample for urine culture?
• She is asymptomatic.
• No indication for culture.
• Provide patient education
NO!
18
Core Competencies 1, 2, 3 & 4
24. What is the likely source?
Severity Source
Drug
resistance
Patient
factors
Cultures
• Cystitis
• Most common uropathogen: E. coli
24
25. What is the likely source?
Severity Source
Drug
resistance
Patient
factors
Cultures
• Consider reasons for recurrent cystitis
and/or alternative diagnoses
25
30. Empiric regimen per guidelines
2016 Public Health England
Uncomplicated Cystitis in Women
First line:
• Nitrofurantoin monohydrate/macrocrystals 100 mg twice daily
Alternatives:
• Trimethoprim 200 mg twice daily
• Pivmecillinam 200 mg three times daily
Core Competency 2
30
31. Adapting guidelines
2010 IDSA/ESCMID Guidelines
2016 PHE Guidance
• Adapt based upon local drug availability and resistance
patterns.
Core Competency 2
31
32. Adapting guidelines
2010 IDSA/ESCMID Guidelines
2016 PHE Guidance
• Adapt based upon local drug availability and resistance
patterns.
• Avoid fluoroquinolones for uncomplicated UTI when alternative
antibiotics are possible.
Core Competency 2
32
33. Clinical case 2
Subsequent evaluationInitial evaluation
Clinical
assessment
Diagnostic
work-up
Patient
education
Therapeutic
decisions
Modify
antimicrobials
Data
review
Clinical
re-assessment
Local guidelines
• E. coli urine isolates
susceptibility pattern:
• 85% trimethoprim-
sulfamethoxazole
• 92% nitrofurantoin
33
36. An appropriate urine sample for culture
• Clean the skin
• Collect midstream
• Use sterile container
• Transportation delays impact
accuracy
• Contribute data for local
surveillance
36
WHO/O. Karatuna
43. Review: Urinary Tract Infections
Drug
Dose
Duration
Route
prescription
.............
.............
.............
Obtain urine culture ONLY when
you clinically suspect a UTI.
43
44. Review: Urinary Tract Infections
Drug
Dose
Duration
Route
prescription
.............
.............
.............
Obtain urine culture ONLY when
you clinically suspect a UTI.
Obtain an appropriate urine
sample for culture.
44
45. Review: Urinary Tract Infections
Drug
Dose
Duration
Route
prescription
.............
.............
.............
Obtain urine culture ONLY when
you clinically suspect a UTI.
Obtain an appropriate urine
sample for culture.
Use local guidelines to guide
empiric antimicrobial choice
and duration.
45