Pharmaceutical Inorganic Chemistry, B.Pharmacy I year I semester Subject

2. Haematinics

3. Total body content of iron is estimated to be about 3 – 4g
Major portion (70%) present in haemoglobin and myoglobin.
Haemoglobin helps to carry oxygen from lungs to
tissues & carbon dioxide from tissue to lungs.
Balance amount distributed as storage iron, transport iron & enzyme
iron.
In normal adults about 1 g of iron is lost from the body daily.
Average daily intake in a normal adult is about 14 mg.
Haematinics

4. Preferred Compounds:
Ferrous Sulphate (20% hydrated salt and dried salt 32% or 65 mg)
Ferrous Gluconate (12% iron or 28 – 36mg).
Other: Ferrous fumerate, Ferrous succinate, Ferric ammonium citrate, Iron
hydroxide etc
Dosage: 200 mg daily in 3 divided doses (3 -5mg/Kg for children)
Side effects: Epigastric pain, heart burn, nausea, vomiting,
staining of teeth, metallic taste, bloating, colic, Constipation

5. Bluish green crystalline
powder with metallic &
astringent taste.
It undergoes slow
oxidation upon exposure
to the moist air to
brown coloured ferric
sulphate.
Hence tablets of ferrous
sulphate are sugar
coated in order to
prevent air oxidation.
It is soluble in water and
insoluble in ethanol
Heated at
higher temp.
decomposes
to ferric
oxide.
•2(FeSO4.7H2O)
→Fe2O3 + SO2+
H2SO4 + 13H2O

6. Preparation:
prepared by adding
excess of 5N H2SO4
to iron dust
Fe + H2SO4 → FeSO4
+ H2(gas)
The crystals of FeSO4
is efflorescent in dry
air
and exposure to
moist air undergoes
slow oxidation
become coated with
brown basic ferric
sulphate,
to that the salt
should be kept in
well closed
conatiner.
Assay: Refer Analysis
Practical manual –
Exp. Assay of
Ferrous Sulphate.

7. Ferrous Gluconate
Uses: To treat iron deficiency anaemia
Assay: As same as FeSO4. It is assayed by use of ceric ammonium sulphate.
BaCl2 is used to precipitagte BaSO4 which is removed by filtration.
Preparation: Gluconic acid is preaped by oxidation of glucose and then dissolving
ferrous carbonate in a calculated amount of gluconic acid.
Description: Yellowish grey or pale greenish yellow fine powder having slight odour
of burnt sugar.
soluble in water and insoluble in ethanol Usual dose is 300 mg thrice a day

8. Thank you