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Khaula Nurrul Hakim (10609044/2009)
Teguh Rachmanto (10609051/2009)
Yangki Sulaeman (10209014/2009)
Luthfi Muawan (10611061/2011)
Maryana (10611014/2011)
LATAR BELAKANG
24 %
>
800
juta
150
ribu
?
apa yang harus kita lakukan
Informasi
Deteksi
Evaluasi
TUJUAN
Na
Cl
Tekanan
Darah
Kreatinin
Urin dan
Serum
Albumin
dan
Glukosa
pada urin
Indeks
Massa
Ginjal
2
1
3
ROAD MAP
2010-2020
Studi Fungsi
Ginjal Terkait
Penyakit Gagal
Ginjal (Struktur,
Fisiologis,
Molekuler)
1.Tahap Inisiasi
2.Tahap Pengembangan
2020-2025
Penyakit Gagal
Ginjal dan
Kaitannya dengan
Fungsi Sistem
Fisiologis Lain
2
1
3
ROAD MAP
2010-2020
Studi Fungsi
Ginjal Terkait
Penyakit Gagal
Ginjal (Struktur,
Fisiologis,
Molekuler)
1.Tahap Inisiasi
2.Tahap Pengembangan
2020-2025
Penyakit Gagal
Ginjal dan
Kaitannya dengan
Fungsi Sistem
Fisiologis Lain
2025-2030
Teknik Deteksi
Dini Penyakit
Gagal Ginjal
3. Tahap hilir /
Tahap lanjut
Objek
Kelompok
Proses
Sumber
Data
x 25
Kontrol
(K)
Perlakuan
(P)
2%
[NaCl]
4%
[NaCl]
8%
[NaCl]
6%
[NaCl]
METODE KERJA
Isolasi
Ginjal
Analisis massa
ginjal/bb
Analisis
histopathology
Hasil dan Pembahasan
Tekanan Darah minggu
ke-5
0
50
100
150
200
250
300
Kontrol 2% 4% 6% 8%
119.47
150.79
215.94
257.64
285.67
Perlakuan
mmHg
Tekanan Darah
minggu ke-6
178.30
126.10
198.63
233.02
269.06
0
50
100
150
200
250
300
Kontrol 2% 4% 6% 8%
Perlakuan
mmHg
Kreatinin Urin
0
40
60
80
100
120
140
160
Kontrol 2% 4% 6% 8%
149.80 146.27
51.23
50.20
27.87
Perlakuan
Konsentrasi
Kreatinin Serum
0
0.05
0.10
0.15
0.20
0.25
0.30
0.35
Kontrol 2% 4% 6% 8%
0.34
0.33
0.28
0.34
0.35
Perlakuan
Konsentrasi
Berat Badan Tikus
334.5
9
312.43
302.4
7 298.81
283.6
8
25
0
260
270
28
0
29
0
30
0
310
320
33
0
34
0
Kontrol 2% 4% 6% 8%
Perlakuan
Gram
Massa Ginjal
0.27000
0.28000
0.29000
0.30000
0.31000
0.32000
0.34000
0.35000
0.36000
0.34000
Kontrol 2% 4% 6% 8%
0.29860
0.30444
0.34312
0.34552
0.34958
Perlakuan
%Indeks
Albumin
Perlakuan Kemunculan
1 2 3 4 5 6
Kontrol
2% [NaCl]
4% [NaCl]
6% [NaCl]
8% [NaCl]
Tidak terdeteksi Terdeteksi
Tekanan Darah
Kontrol
2% [NaCl]
4% [NaCl]
6% [NaCl] 8% [NaCl]
Konsentrasi NaCl Tekanan darah
Kreatinin
Kontrol
2% [NaCl]
4% [NaCl]
6% [NaCl] 8% [NaCl]
Konsentrasi NaCl Kreatinin
Berat Badan
Kontrol
2% [NaCl]
4% [NaCl]
6% [NaCl] 8% [NaCl]
Konsentrasi NaCl Berat Badan
Indeks Massa Ginjal
Konsentrasi NaCl Indeks Massa Ginjal
Kontrol
6% [NaCl]
2% [NaCl]
8% [NaCl]
4% [NaCl]
KENDALA
1 Masalah Teknis dan Waktu
Keberadaan alat penelitian yang
terbatas
2Masalah Keuangan
Keterbatasan dana
terutama untuk membeli antibody
3
Masalah Sumber Daya
Perbedaan waktu yang dimiliki
setiap peneliti menyebabkan
progress penelitian berjalan
lamban
TANGGAL
PENGELUARAN
NAMA BARANG SATUAN JUMLAH BARANG
HARGA SATUAN
(RP)
TOTAL HARGA
(RP)
27 DESEMBER 2012 AQUADES LITER 15 RP500 RP7,500
02 JANUARI 2013 LATEKS BUAH 4 RP42,500 RP170,000
02 JANUARI 2013 VIAL 5ML BUAH 10 RP400 RP4,000
02 JANUARI 2013 TUTUP KARET VIAL BUAH 10 RP110 RP1,100
10 JANUARI 2013
VACUETAINER TUBE
PLAIN 4 ML
10 RP2,250 RP22,500
15 JANUARI 2013 UJI KREATININ URIN SAMPEL 21 RP40,000 RP840,000
25 FEBRUARI 2013
VACUETAINER TUBE
PLAIN 4 ML
BH 14 RP2,500 RP35,000
25 FEBRUARI 2013
VACUETAINER
HEPARIN 3 ML
BH 14 RP2,750 RP38,500
10 MEI 2013 OBJECT GLASS 1 RP12,000 RP12,000
10 MEI 2013 MASKER 1 RP25,000 RP25,000
10 MEI 2013
KOTAK PREPARAT
KAYU
2 RP27,500 RP55,000
19 JUNI 2013
BIAYA SEWA ALAT
TAIL CUFF
BULAN RP200,000 RP200,000
03 JULI 2013 TUTUP KARET VIAL 30 RP450 RP13,500
04 DESEMBER 2013
AQUABIDEST STERIL-
500 ML
BOTOL 1 RP17,500 RP17,500
19 DESEMBER 2013 DIPSTICKURIN DUS 10 RP125,000 RP1,250,000
Penggunaan Biaya
21 JANURARI 2013 MASKER 3 RP25,000 RP75,000
25 NOVEMBER 2013 ALAT TULIS KANTOR 1 RP89,700 RP89,700
PAKAN TIKUS KG 20 RP7,500 RP150,000
SEKAM KARUNG 3 RP10,000 RP30,000
ALAT BEDAH SET 1 RP125,000 RP125,000
SYRINGE 10CC BUAH 100 RP2,250 RP225,000
SARUNG TANGAN DUS 5 RP60,000 RP300,000
KACA OBJEK DUS 5 RP25,000 RP125,000
KACA PENUTUP KOTAK 10 RP30,000 RP300,000
TIPS PUTIH BUAH 100 RP500 RP50,000
TIPS BIRU BUAH 100 RP200 RP20,000
TEMPAT TIPS PUTIH-
KUNING
BUAH 1 RP25,000 RP25,000
TEMPAT TIPS BIRU BUAH 1 RP33,000 RP33,000
TISU PAK 6 RP24,000 RP144,000
BIAYA PERJALANAN 30 RP10,000 RP300,000
UJI KREATININ SERUM SAMPEL 18 RP40,000 RP720,000
BAHAN-BAHAN KIMIA RP1,110,400
TOTAL RP7,773,700
Dokumentasi Kegiatan
• Ross C. Brownson, Patrick L. Remington, James R. davis, High Blood Pressure in Chronic Disease
Epidemiology and Control. Second Edition, American Public Health Assosiation: 262-264.
• Kearney Patricia M, Whelton Megan, Reynolds Kristi, et.al., Global Burden of Hypertension:
Analysis of Worldwide Data. New Orleans:The Lancet, 2002; 217, 221-222
• Levey, A. S., Coresh, J., Balk, E., Kausz, A. T., Levin, A., Steffes, M. W., Hogg, R. J., Perrone, R.D.,
Lau, J., Eknoyan, G. 2003. National kidney foundation practice guidelines for chronic kidney
disease: evaluation, classification and stratification. Ann Intern Med 139: hal 137-147.
• Radharjo, Pudji. 2007. Kaitan Antara Hipertensi dan Penyakit Ginjal. Universitas Indonesia;
Depok Diakses pada http://ebookbrowse.com/kaitan-antara-hipertensi-dan-penyakit-ginjal-pdf-
d363034096 tanggal akses 4 Oktober 2012 pukul 18.39 WIB
• Sherwood, L. 2001. Human Physiology: From Cells to Systems. West Virginia: International
Thomson Publishing.
• Sigarlaki, H. J. O. 1995. Faktor-faktor Resiko Penderita Hipertensi di RSU FK-UKI. Jakarta: Program
Studi Pascasarjana Ilmu Kesehatan Masyarakat.
• Sekikawa, A. dan Hayakawa, T. 2004. Prevalence of Hypertension, Its Awareness and Control in
Adult Population in Japan. Journal of Human Hypertension 18 hal. 911-912
• Tryggvason, K. 1999. Unraveling The Mecanisms of Glomerular Ultrafiltration: Nephrin, The Key
Component of The Slit Diaphragma. J Am Soc Nephrol 10: 2440-2445.
• Tryygvason, K., Khoshnoodi, J. 2001. Unraveling the molecular make-up of the glomerular
podocyte slit diafragma. Exp. Nephrol 9: hal 355-359.
Daftar Pustaka
terima kasih
hatur nuhun
ありがとう
dank u
감사합니다
danke
grazie
thank you
matur nuwun

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UJI EVALUASI DETEKSI DINI PENYAKIT GAGAL GINJAL PADA TIKUS (RATTUS NOVERGICUS, WISTAR) YANG DIINDUKSI HIPERTENSI

Editor's Notes

  1. F tabel (4,25) = 2.76, F hitung = 217.238, tolak null hypothesisTukey test memberikanperbedaanuntukmasing-masingkelompokPearson test, r = 0.977 (positif), P < 0.05, terdapatkorelasistatistik yang signifikan
  2. F tabel (4,10) = 3.48, F hitung = 9.957, tolak null hypothesisTukey test memberikanperbedaanuntukmasing-masingkelompokPearson test, r = -0.822 (negatif), P < 0.05, terdapatkorelasistatistik yang signifikan
  3. F tabel (4,20) = 2.87, F hitung = 4.514, tolak null hypothesisTukey test memberikanperbedaanuntukmasing-masingkelompokPearson test, r = -0.667 (negatif), P < 0.05, terdapatkorelasistatistik yang signifikan
  4. F tabel (4,20) = 2.87, F hitung = 1.769, terima null hypothesisPearson test, r = 0.470 (positif), P > 0.05, tidakterdapatkorelasistatistik yang signifikan