The document summarizes an ultrastructural investigation of the detrusor muscle in the bladder of patients with benign prostatic hyperplasia (BPH) before and after treatment with the drug tamsulosin. Before treatment, the detrusor showed signs of damage to smooth muscle cells and fibroblasts, disorganized mitochondria, and impaired microcirculation. After three months of tamsulosin treatment, ultrastructural analysis found improvements including preserved smooth muscle cells and noncellular structures, improved microcirculation, and an absence of preapoptotic changes. The study concludes that tamsulosin has a positive effect on detrusor ultrastructure and microcirculation in patients with BPH.

1. The changes of ultrastructure of detrusor in patients with benign prostatic hyperplasia during treatment by tamsulosin A. Lychkovsky, A. Zhuravchak, A. Shuliak, V. Kovalyshyn, Yu. Borys Lviv Danylo Halytsky National Medical University