overview on ischemic heart disease and medicines

1. NETAJI SUBHAS CHANDRA BOSE INSTITUTE OF PHARMACY
URMISTHA SARKAR
3RD YEAR, ROLL NO: B14002

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3. Coronary circulation is the
circulation of blood in
the blood vessels` of
the heart muscle
(myocardium). The vessels that
deliver oxygen-rich blood to
the myocardium are known
as coronary arteries. The
vessels that remove the
deoxygenated blood from the
heart muscle are known as
cardiac veins. These include
the great cardiac vein,
the middle cardiac vein ,
the small cardiac vein and
the anterior cardiac veins.
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4.  Ischemic heart Disease, also known as
Coronary Artery Disease, is a condition that
affects the supply of blood to the heart.
The blood vessels are narrowed or blocked
due to the deposition of cholesterol on their
walls.
 This reduces the supply of oxygen and
nutrients to the heart muscles, al for proper
functioning of the heart. which is essential for
proper functioning of heart
 This may eventually result in a portion of the
heart being suddenly deprived of its blood
supply leading to the death of that area of
heart tissue, resulting in a heart attack.
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6. Heart disease
Controllable risk
factors
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7. ANGINA PECTORIS
NAUSEA ORVOMITING
SWEATING
PALLOR
(PALE SKIN)
ANXIETY
“CRUSHING”
(CHEST PAIN)
DIFFICULTY
BREATHING
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8. Coronary artery cannot supply enough blood to the heart in response to the
demand due to CAD
Within 10 seconds myocardial cells experience ischemia
Ischemic cells cannot get enough oxygen or glucose
Ischemic myocardial cells may have decreased electrical and muscular function
Cells convert to anaerobic metabolism
Cells produce lactic acid as waste
Pain develops from lactic acid accumulation
Patient feels anginal symptoms until receiving demand increase oxygen requirements of
myocardial cells
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9. ELECTROCARDIOGRAM
ECHOCARDIOGRAM
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10. STRESSTEST CORONARY ANGIOGRAM
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11. HEART SCAN
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13. ORGANIC NITRATES:-Organic nitrates relax the non specific smooth muscles.
DRUGS: Isosorbide Dinitrate
Isosorbide Mononitrate
MECHANISM OF ACTION:
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14. BETA BLOCKERS:- Beta blockers act by reducing cardiac work and oxygen
consumption
MECHANISM OF ACTION:
DRUGS: Propanolol
Atanolol
Timolol
PHARMACEUTICAL TREATMENT 13/18

15. CALCIUM CHANNEL BLOCKERS:-
MECHANISM OF ACTION:
DRUGS: Amlodipine
Nifedipine
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16. STATINS:- It reduces cholesterol ,reduce risk of coronary disease
MECHANISM OF ACTION:
DRUGS: Atorvastain
Rusvastain
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17. ASPIRIN:-
MECHANISM OF ACTION:
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18. CORONARY ARTERY BYPASSGRAFTING
•BEATING HEART SURGERY
•ARRESTED HEART SURGARY
MINIMALLY INVASIVETREATMENT
•CORONARY BALLOONANGIOPLASTY
•STENTING
•MICS CABG
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19. 1. A balloon and stent in a catheter are
fed through arteries to the blockage
and caused the disease
2. At the blockage the balloon is
inflated opening up the stent
3. The balloon is deflated, leaving
stent in place to keep artery open to
improve flow of blood
4. Cells are removed from bone marrow
in the patient’s hip under local
anesthetic
5.These are taken to a lab where
muscle stem cells are separated
from red cells
6.They are then injected into artery
where they travel to the heart to
repair the damaged heart muscle
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