Opening up the Research Communications Ecosystem

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Tim Clark

talk by Tim Clark at Beyond the PDF workshop, San Diego CA, 19-21 Jan 2011

Technology

Tim Clark Harvard Medical School & Massachusetts General Hospital January 19, 2011 Copyright 2011 Massachusetts General Hospital. All rights reserved.

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MCI progressors non progressors PET imaging of PIB (radiolabelled compound binds amyloid beta A4 protein) MRI imaging of brain structure showing loss of hippocampal volume Brain. 2010 Nov;133(Pt 11):3336-3348 . = 218 subjects +

create hypothesis design experiment run experiment collect data interpret data share interpretations synthesize knowledge

dopaminergic pathway α-synuclein, β-amlyoid α-synuclein, Tau chr 16p11.2 CNV chr 16p11.2 CNV CRF, glutaminergic system, dopamine, amygdala … Alzheimer Disease Parkinson’s Disease Schizophrenia Autism Bipolar Disorder Drug Addiction Huntington’s Disease ALS Depression SIRT2

We scientists do not attend professional meetings to present our findings ex cathedra, but in order to argue. John Polanyi, FRS

Genes Proteins Biological Processes Chemical Compounds Antibodies Cells Brain anatomy …

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Parkinson’s Disease Stem Cell Technology

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4. MCI progressors non progressors PET imaging of PIB (radiolabelled compound binds amyloid beta A4 protein) MRI imaging of brain structure showing loss of hippocampal volume Brain. 2010 Nov;133(Pt 11):3336-3348 . = 218 subjects +

5. create hypothesis design experiment run experiment collect data interpret data share interpretations synthesize knowledge

6. dopaminergic pathway α-synuclein, β-amlyoid α-synuclein, Tau chr 16p11.2 CNV chr 16p11.2 CNV CRF, glutaminergic system, dopamine, amygdala … Alzheimer Disease Parkinson’s Disease Schizophrenia Autism Bipolar Disorder Drug Addiction Huntington’s Disease ALS Depression SIRT2

7. 1667 2010 Printing Press Web

8. We scientists do not attend professional meetings to present our findings ex cathedra, but in order to argue. John Polanyi, FRS

9. Genes Proteins Biological Processes Chemical Compounds Antibodies Cells Brain anatomy …

10. Text Shared metadata

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12. Dr. Paolo Ciccarese – Oct 8, 2010

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19. Parkinson’s Disease Stem Cell Technology

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Opening up the Research Communications Ecosystem

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