The document discusses sharing data and findings in medical research to advance understanding of conditions like Alzheimer's disease and Parkinson's disease. It notes that researchers who shared their data on amyloid beta protein and brain imaging were able to create hypotheses, design experiments, and synthesize new knowledge. The document advocates opening up published research to arguments from other scientists and integrating documents with semantic metadata and text mining applications.

2. Tim Clark Harvard Medical School & Massachusetts General Hospital January 19, 2011 Copyright 2011 Massachusetts General Hospital. All rights reserved.

3. … [we] parked our egos and intellectual-property noses outside the door and agreed that all of our data would be public immediately.” John Trojanowski, MD, PhD U Penn Medical School Sharing of Data Leads to Progress on Alzheimer’s , NY Times, 12 Aug 2010

4. MCI progressors non progressors PET imaging of PIB (radiolabelled compound binds amyloid beta A4 protein) MRI imaging of brain structure showing loss of hippocampal volume Brain. 2010 Nov;133(Pt 11):3336-3348 . = 218 subjects +

5. create hypothesis design experiment run experiment collect data interpret data share interpretations synthesize knowledge

6. dopaminergic pathway α-synuclein, β-amlyoid α-synuclein, Tau chr 16p11.2 CNV chr 16p11.2 CNV CRF, glutaminergic system, dopamine, amygdala … Alzheimer Disease Parkinson’s Disease Schizophrenia Autism Bipolar Disorder Drug Addiction Huntington’s Disease ALS Depression SIRT2

7. 1667 2010 Printing Press Web

8. We scientists do not attend professional meetings to present our findings ex cathedra, but in order to argue. John Polanyi, FRS

9. Genes Proteins Biological Processes Chemical Compounds Antibodies Cells Brain anatomy …

10. Text Shared metadata

12. Dr. Paolo Ciccarese – Oct 8, 2010

15. <rdf:Description rdf:about=&quot;http://swan.mindinformatics.org/annotationset/6&quot;> <rdf:type rdf:resource=&quot;http://purl.org/ao/AnnotationSet&quot;/> <rdfs:label>Species</rdfs:label> </rdf:Description> − <rdf:Description rdf:about=&quot;http://swan.mindinformatics.org/annotationitem/11&quot;> <rdf:type rdf:resource=&quot;http://purl.org/ao/types/Qualifier&quot;/> <pav:createdOn rdf:datatype=&quot;java:java.sql.Timestamp&quot;>2011-01-06T13:58:29.000000000-05:00</pav:createdOn> </rdf:Description> − <rdf:Description rdf:about=&quot;http://swan.mindinformatics.org/agentperson/2&quot;> <rdf:type rdf:resource=&quot;http://xmlns.com/foaf/0.1/Person&quot;/> <foaf:mbox>paolo.ciccarese@gmail.com</foaf:mbox> <foaf:firstName>Paolo</foaf:firstName> − <foaf:img> http://swan.mindinformatics.org/imgs/people/paolo-ciccarese_.jpg </foaf:img> <foaf:lastName>Ciccarese</foaf:lastName> <foaf:homepage>http://www.hcklab.org/paolo-ciccarese-cv.html</foaf:homepage> <foaf:name>Paolo Ciccarese</foaf:name> </rdf:Description> − <rdf:Description rdf:about=&quot;http://swan.mindinformatics.org/annotationitem/11&quot;> <pav:createdBy rdf:resource=&quot;http://swan.mindinformatics.org/agentperson/2&quot;/> </rdf:Description> − <rdf:Description rdf:about=&quot;http://swan.mindinformatics.org/prefixpostfixtextselector/1&quot;> <rdf:type rdf:resource=&quot;http://purl.org/ao/selectors/PrefixPostfixTextSelector&quot;/>]

18. SWAN Annotation http://vimeo.com/18510599 Utopia Annotation http://www.scivee.tv/node/26720

19. Parkinson’s Disease Stem Cell Technology

20. Opening up the static document on the Web Integrating the Web of documents with the Web of data (semantic web) Exploiting synergies with textmining apps Creating an ecosystem of semantic metadata on scientific publications

21. New models of Semantic Publishing in Science Guest Editors: P Bourne, T Clark, A de Waard, C Goble, S Pettifer, D Shotton Call for papers next week Send us your best work!