Neuroimaging Lecture

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Neuroimaging Lecture

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  • Figure MRI of childs head
  • Figure Left CT scan showing intracranial tumor
  • Axial plane CT vs MRI of brain tumor, same subject-mri clearly has better contrast resolution.
  • Dystonia caused by defect in copper excretion
  • WHO Grade IV Cell of Origin: ASTROCYTE Synonyms: GBM, glioblastoma multiforme, spongioblastoma multiforme Common Locations: cerebral hemispheres, occasionally elsewhere (brainstem, cerebellum, cord) Demographics: peak from 45-60 years Histology: grossly heterogeneous, degeneration, necrosis and hemorrhage are common Special Stains: GFAP varies, often present in areas of better differentiation Progression : Can't get any worse. Radiology: Glioblastoma is usually seen as a grossly heterogeneous mass. Ring enhancement surrounding a necrotic center is the most common presentation, but there may be multiple rings. Surrounding vasogenic edema can be impressive, and adds significantly to the mass effect. Signs of recent (methemoglobin) and remote (hemosiderin) hemorrhage are common. Despite it’s apparent demarcation on enhanced scans, the lesion may diffusely infiltrate into the brain, crossing the corpus callosum in 50-75% of cases.
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