Armotraz Tablets (Generic Anastrozole Tablets)

Armotraz Tablets (Generic Anastrozole Tablets)
© The Swiss Pharmacy

Armotraz (Generic Anastrozole 1 mg Tablets) is an
aromatase inhibitor which is used for adjuvant treatment of
postmenopausal women with hormone receptor-positive
early breast cancer.
They are also used for first-line treatment of
postmenopausal women with hormone receptor-positive or
hormone receptor unknown locally advanced or metastatic
breast cancer and for the treatment of advanced breast
cancer in postmenopausal women with disease progression
following Tamoxifen therapy.

Armotraz Tablets are manufactured by Cipla
Limited, India in the strength of 1 mg.

Chemical Structure

The active ingredient contained in Armotraz tablets is
Anastrozole. Each film-coated Armotraz tablet contains
1 mg of Anastrozole.

Uses of Armotraz 1 mg Tablets:
Armotraz contains an ingredient called Anastrozole. This belongs to a
group of medicines called 'aromatase inhibitors'. Armotraz is used to
treat breast cancer in women who have gone through the menopause.
This medicine is used to treat the following indications:
Adjuvant treatment of postmenopausal women with hormone receptor-
positive early breast cancer.
First-line treatment of postmenopausal women with hormone receptor-
positive or hormone receptor unknown locally advanced or metastatic
breast cancer.
Treatment of advanced breast cancer in postmenopausal women with
disease progression following Tamoxifen therapy.
URL: https://www.theswisspharmacy.com/product_info.php?info=p9896_Anastrozole-Tablets.html

Uses of Armotraz 1 mg Tablets:
Many breast cancer tumors grow in response to estrogen. This medicine
interferes with the production of estrogen in the body. As a result, the
amount of estrogen that the tumor is exposed to is reduced, limiting the
growth of the tumor.
Patients with ER-negative disease and patients who did not respond to
previous Tamoxifen therapy rarely responded to Armotraz tablets.
Anastrozole tablets works by cutting down the amount of the hormone
called estrogen that your body makes. It does this by blocking a natural
substance (an enzyme) in your body called ‘aromatase’.

Uses of Armotraz 1 mg Tablets in Bodybuilding (Off-Label):
Some bodybuilders take Anastrozole to reduce the side effects of
anabolic steroids. The drug is a breast cancer treatment that lowers
estrogen levels and should not be used for other means.
Bodybuilders who take anabolic steroids to try to increase muscle mass
and improve athletic performance can experience a range of symptoms.
In some cases, males might start to grow breasts due to an increase in
estrogen levels.
Anastrozole lowers estrogen levels and can prevent breast growth in
males. Anastrozole stops aromatase from working in the body.
Aromatase is an enzyme that makes estrogen from steroid hormones,
including testosterone. By doing this, it lowers the amount of estrogen in
the body.

Recommended Adult Dosage
The dose of Armotraz Tablets (Generic Anastrozole Tablets) is
one 1 mg tablet taken once a day. For patients with advanced
breast cancer, Armotraz Tablets should be continued until
tumour progression. Armotraz Tablets can be taken with or
without food.
For adjuvant treatment of early breast cancer in postmenopausal
women, the optimal duration of therapy is unknown. In the ATAC
(the Anastrozole, Tamoxifen, Alone or in Combination study) trial,
Anastrozole was administered for 5 years.

Anastrozole tablets are not recommended for use in children
and adolescents due to insufficient data on safety and efficacy.
No dosage adjustment is necessary for elderly patients.
No changes in dose are recommended for patients with
mild-to-moderate hepatic impairment.
Anastrozole tablets have not been studied in patients with
severe hepatic impairment.
Anastrozole is not recommended for use in children and
adolescents due to insufficient data on safety and efficacy.
No dosage adjustment is necessary for elderly patients.

Armotraz (Anastrozole tablets) may be used by bodybuilders to block
estrogen.
Armotraz may help prevent side effects such as gynecomastia (male
breast enlargement) from developing due to the aromatization of
anabolic steroids.
When used for this purpose, Anastrozole (Armotraz tablets) is typically
introduced in week two of the cycle and taken for the entire length of
the cycle at 0.5 mg twice a week.
Anastrozole (Armotraz tablets) is only approved by the Food and Drug
Administration (FDA) for use in breast cancer treatment.
There are no formal guidelines for its use in bodybuilding.

Contraindications
➔
Armotraz tablets are contraindicated in any patient who has
shown a hypersensitivity reaction to Anastrozole or to any of the
inactive ingredients present in Anastrozole tablets. Observed
reactions include anaphylaxis, angioedema, and urticaria.
➔
Armotraz tablets may cause fetal harm when administered to a
pregnant woman and offers no clinical benefit to
premenopausal women with breast cancer.
➔
Armotraz (Anastrozole Tablets) is contraindicated in women of
premenopausal endocrine status, including pregnant women.

Storage Instructions
Armotraz Tablets (Generic Anastrozole Tablets) have
to be stored at controlled room temperature i.e. from
20°C to 25°C (68°F to 77°F) with excursions permitted
between 15° to 30°C (59° to 86°F).
Keep this as well as all other medicines away from
children and pets.

Warnings
In women with pre-existing ischemic heart disease, an increased
incidence of ischemic cardiovascular events occurred with Anastrozole
Tablets (Armotraz) use compared to Tamoxifen use. Consider risks and
benefits.
Decreases in bone mineral density may occur.
As Anastrozole lowers circulating estrogen levels it may cause a
reduction in bone mineral density with a possible consequent
increased risk of fracture. Consider bone mineral density monitoring.

Warnings
Increases in total cholesterol may occur. Consider cholesterol
monitoring.
Anastrozole should not be used in premenopausal women.
Anastrozole has not been investigated in breast cancer patients with
moderate or severe hepatic impairment.
Exposure to Anastrozole can be increased in subjects with hepatic
impairment. Administration of Armotraz in patients with moderate and
severe hepatic impairment should be performed with caution.

Warnings
Anastrozole has not been investigated in breast cancer patients with
severe renal impairment. In patients with severe renal impairment,
administration of Armotraz should be performed with caution.
Armotraz is not recommended for use in children and adolescents as
safety and efficacy have not been established in this group of patients.
This product contains lactose. Patients with rare hereditary problems of
galactose intolerance, the Lapp lactase deficiency or glucose-
galactose malabsorption should not take Armotraz tablets.

Warnings
Anastrozole is not recommended for use in children and adolescents
as safety and efficacy have not been established in this group of
patients.
Anastrozole should not be used in boys with growth hormone
deficiency in addition to growth hormone treatment. In the pivotal
clinical trial, efficacy was not demonstrated and safety was not
established.
Since Anastrozole (Armotraz Tablets) reduces estradiol levels,
Anastrozole tablets must not be used in girls with growth hormone
deficiency in addition to growth hormone treatment. Long-term safety
data in children and adolescents are not available.

Possible Side Effects
In the early breast cancer (ATAC) study, the most common
(occurring with an incidence of more than 10%) side effects
occurring in women taking Anastrozole tablets (Armotraz)
included: hot flashes, asthenia, arthritis, pain, arthralgia,
pharyngitis, hypertension, depression, nausea and vomiting, rash,
osteoporosis, fractures, back pain, insomnia, headache,
peripheral edema and lymphedema, regardless of causality.

Possible Side Effects
In the advanced breast cancer studies, the most
common (occurring with an incidence of greater than 10%)
side effects occurring in women taking Anastrozole
tablets (Armotraz) included: hot flashes, nausea, asthenia,
pain, headache, back pain, bone pain, increased cough,
dyspnea, pharyngitis and peripheral edema.

Armotraz Tablets Overdosage
Clinical trials have been conducted with Anastrozole (Armotraz
Tablets) tablets, up to 60 mg in a single dose given to healthy male
volunteers and up to 10 mg daily given to postmenopausal
women with advanced breast cancer; these dosages were
tolerated.
A single dose of Anastrozole that results in life-threatening
symptoms has not been established.

Treatment of Armotraz Tablets Overdosage
There is no specific antidote to Anastrozole (Armotraz Tablets)
overdosage and treatment must be symptomatic. In the management
of an overdose, consider that multiple agents may have been taken.
Vomiting may be induced if the patient is alert.
Dialysis may be helpful because Anastrozole is not highly protein
bound. General supportive care, including frequent monitoring of
vital signs and close observation of the patient, is indicated.

Armotraz Tablets During Pregnancy
Anastrozole (Armotraz tablets) has been classified by the US FDA as
Pregnancy Category X.
Anastrozole (Armotraz tablets) may cause fetal harm when administered to
a pregnant woman and offers no clinical benefit to premenopausal women
with breast cancer. Anastrozole is contraindicated in women who are or
may become pregnant. In animal studies, Anastrozole tablets caused
pregnancy failure, increased pregnancy loss, and signs of delayed fetal
development.
There are no studies of Anastrozole use in pregnant women.
In case Anastrozole (Armotraz tablets) is used during pregnancy, or if the
patient becomes pregnant while receiving this drug, the patient should be
apprised of the potential hazard to the fetus and potential risk for
pregnancy loss.

Armotraz Tablets (Generic Anastrozole Tablets) are
manufactured by Cipla Limited, India.

Armotraz Tablets (Generic Anastrozole Tablets)

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