3. Endometriosis
• Endometriosis is a common and painful condition
characterized by the existence of endometrial glands and
stroma outside the uterine cavity (endometrial implant).
• Endometriosis present with severe symptoms such as chronic
pelvic pain, pain with menstruation, pain during intercourse
(dyspareunia) and dysmenorrhea
4. Significance
Endometriosis is one of the most enigmatic
diseases:
• the etiology and underlying pathophysiology
is still largely unknown
• endometriosis impairs the quality of life of
women of reproductive age
• in 30% leads to infertility
5.
6. Analogs
Hormone therapy Surgery Symptomatic
treatment
Personalized
approach
Non-specific,
long-term, often
lifetime
has many side effects
Does not eliminate the
cause of the disease,
high probability of
recurrence
"Operation of despair"
Short-term relief of
symptoms,
does not cure the
disease,
has side effects
Specificity
correction of
intracellular damage,
low probability of
recurrence
less side-effects
1 course of therapy+
IVF= $ 5500
1 operation + hormone
therapy + IVF =
$ 6700
1 course of therapy +
IVF = $ 5250
1 biopsy + 1 genetic
analysis + the cost of
drugs = $ 760
7. Competitive advantages
• individual approach to treatment
• effective targeted selection of drugs
• lower economic cost of treatment
• optimization of the making decision on the
treatment option for each patient
9. Current state
• Bioinformatic analysis of the main signaling pathways
involved in pathogenesis of endometriosis in the article
«Molecular aspects of development and regulation of
endometriosis» in Reproductive Biology and
Endocrinology Journal
• Perspective article about possibility of using Oncofinder
software to implement the idea
10.
11. Planned
• Creating a database of intracellular changes that
underlie endometriosis
• Creating the medical protocol of personalized
approach to diagnosis and treatment of
endometriosis
• Obtaining a patent on intellectual property
14. Business model
Counseling CenterPotential customers
• Department of Obstetrics and
Gynecology in Hospitals
• Reproductive centers
• Fertility clinics
Genetic Testing
Personalized treatment
16. Thank you for your attention!
Yana Aznaurova
aznaurova.endo@gmail.com
www.ScientistDoctor.com
Федеральный научно-клинический центр
детской гематологии,
онкологии и иммунологии
им. Димы Рогачёва
