ito cells or hepatic stellate cells

1. Ito cells
Soroush Sarmadi
“Shiraz university”
“Faculty of veterinary medicine”
“Department of clinical science”

2. Liver histology

3. Ito cells
-The other cell type found in the peri-sinusoidal space is the
hepatic stellate cell or Ito cell.
-Ito cells are located in the liver in the space of Disse.

4. Electron micrograph of two hepatic sinusoids of the liver:

5. Ito cells
-These cells of mesenchymal origin.
-Primary storage site for hepatic vitamin A.
-Vitamin A is released from the hepatic stellate cell as retinol
(alcohol form) bound to retinol-binding protein (RBP).
-It is then transported from the liver to the retina, where its
stereoisomer 11-cis-retinal binds to the protein opsin to form
rhodopsin, the visual pigment of rods and cones of the retina.

6. Retinol-binding protein
-Retinol-binding proteins (RBP) are a family of proteins with
diverse functions.
-They are carrier proteins that bind retinol.
-RBP is synthesized within the liver.
-secretion being dependent upon retinol concentrations.

7. Ito cells
-In certain pathologic conditions, such as chronic inflammation
or liver cirrhosis, hepatic stellate cells lose their lipid and vitamin
A storage capability and differentiate into cells with characteristics
of myofibroblasts.
-they synthesize and deposit type I and type III collagen within the
peri-sinusoidal space, resulting in liver fibrosis.
-hepatic stellate cells play a role in remodeling the extracellular
matrix during recovery from liver injury.

8. Ito cell

9. Thanks for your attention