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Challenges in Management of Advanced Heart Disease
“ YTP UPDATE 2020”
Author - Dr Indranil Dutta
MBBS, MS(OBG), FIAOG, FAGE, FIAMS
Dip in Advanced Gynae Endoscopy(Germany)
Associate Prof, IQCMC, Durgapur
President KOGS
Dr. Neharika M Bora
MD(obgyn), DRM Germany
Rainbow IVF, Agra
BROUGHT TO YOU BY
YTP CHAIRPERSON
Cardiovascular disease is a leading cause of maternal death. The normal cardiovascular hemodynamic
adaptations to pregnancy are remarkable, but tolerated without difficulty in the majority of women. However, in women
with cardiovascular dysfunction, these adaptations may precipitate cardiovascular decompensation. Risk stratification of
pregnancy risk should preferably take place before conception. Management of these women requires multidisciplinary
involvement of all key areas, including cardiology, nursing, maternal/fetal medicine and obstetric anesthesia. For higher-
risklesions,pregnancyshouldbemanagedincenterswithexpertiseinthisfield.
There are numerous contributors of this rising risk, including advancing maternal age, pre-existing
cardiovascular risk factors, the rise in multifetal pregnancies and survival to fertility age among childhood cancer
survivors and women with congenital heart disease. Unlike most cardiovascular conditions, there are no large randomized
controlledtrialstoguidedecision-making,andguidelinesarebasedprincipallyonexpertconsensus.
It is increasingly likely that a cardiologist will be called upon to manage these women, so it is incumbent upon
them to understand the basic cardiovascular hemodynamics of pregnancy and fundamental risk stratification and
management oftheseconditions.
In the United States, disease and dysfunction of the heart and vascular system as “cardiovascular disease” is
now the leading cause of death in pregnant women and women in the postpartum period accounting for 4.23 deaths per
100,000 live births, a rate almost twice that of the United Kingdom. The most recent data indicate that cardiovascular
1
diseasesconstitute 26.5%ofU.S.pregnancy-relateddeaths .
CHD was the most common form of heart disease complicating pregnancy in the Western world (accounting for
74% of cases in the Canadian Cardiac Disease in Pregnancy [CARPREG] registry and 66% of cases in the European
Registry on Pregnancy and Cardiac Disease [ROPAC] registry), whereas in less developed countries, rheumatic heart
2,3
diseaseplaysalargerrole
The normal cardiovascular hemodynamic adaptations to pregnancy are remarkable but tolerated without
difficulty in the majority of women. In women with cardiovascular dysfunction, however, these adaptations may precipitate
cardiovascular decompensation. Hemodynamic changes begin in the first trimester, with a 30–50 % rise in cardiac output,
driven by an increase in stroke volume and, to a lesser extent, heart rate. Systemic vascular resistance falls as a result of
endogenous vasodilators, as well as flow into the low-resistance uteroplacental unit. During labor and delivery, cardiac
output is further increased because of auto transfusion from the contracting uterus as well as an increase in heart rate
becauseofmaternalpainduring labor.
Hemodynamics of Pregnancy
The care of pregnant women with heart disease involves several stakeholders with different perspectives but
common goals: pre-conceptional counselling is important followed by delivery of a healthy baby and a mother free of
cardiac complications. This team should include an obstetric anesthesiologist, maternal fetal medicine specialist, nursing
staffandacardiologistwithexpertiseinthemanagement ofpregnantwomen
Multidisciplinary Care
Women with mechanical heart valves have an elevated risk of complications during pregnancy and only a 58 %
chance of a having an uncomplicated pregnancy with a live birth. The use of anticoagulants during pregnancy is
challengingandinfluencedbyahypercoagulablestateandchangesinthevolumeofdistribution andcreatinine clearance
Anticoagulation for Mechanical Heart Valves
Fortunately, pregnancy-associated acute MI (PAMI) is uncommon, although its incidence is increasing and inhospital
mortality remains high at 4.5 %The management of PAMI is individualized. However, in the presence of hemodynamic
instability, heart failure or refractory chest pain, angiography is warranted. As a high proportion of PAMI cases are caused
by SCAD, in which coronary angiography can propagate dissection, methods to reduce coronary manipulation are
recommended such as avoiding deep catheter engagement of the coronary ostia and gentle contrast injections. Coronary
CT may have an emerging role in the population of patients who are at a lower risk with suspected CAD, and provides
additionaldataonthevesselwallsuchaspresenceofplaque,intramuralhematomaordissection.
Acute MI During Pregnancy
Despite the increased hemodynamic burden of labor and delivery, including a further increase in heart rate, stroke volume
and cardiac output, vaginal delivery remains the optimal method of delivery. Cesarean section increases the risk of
maternal infection, leads to great hemodynamic shifts and blood loss, brings a risk of surgical injury and raises the
likelihood of thrombotic events. Although there is no consensus over absolute contraindications for vaginal delivery,
cesarean section can be considered for some women with certain cardiac conditions, including preterm labor in those
receiving full oral anticoagulation, Marfan's syndrome with an aorta over 45 mm, acute or chronic aortic dissection, and
intractableheartfailure.Generally,cesareansectionisreservedforobstetricalindications
Mode of Delivery
Fetaloutcomesarealsoimpaired in somemotherswith CHD.Higher chancesofIUGRwith LowBurth Weight babies.More
incidences of preterm labour, increased risk of miscarriage or intrauterine demise, and increased perinatal mortality.
Decreased maternal cardiac output and maternal cyanosis are significantly associated with an increase in fetal
4,5
complications .
Impact on Fetal Outcomes
Cardiovascular disease is a leading cause of maternal death. Cardiovascular training programs are increasingly providing
education on the management of cardiovascular disorders during pregnancy and it is increasingly likely that cardiologists
willbecalledupontomanagethesewomen.
Conclusion
1. ACOG Practice Bulletin No. 212: Pregnancy and Heart Disease, Author Information, Obstetrics & Gynecology: May
2019-Volume133-Issue5-pe320-e356,doi:10.1097/AOG.0000000000003243
2. Siu S, Sermer M, Colman J, Alvarez N, Mercier L, Morton B, Kells C, Bergin L, Kiess M, Marcotte F, Taylor D, Gordon E,
Spears J, Tam J, Amankwah K, Smallhorn J, Farine D, Sorensen S. Prospective multicenter of pregnancy outcomes in
womenwithheartdisease.Circulation.2001;104:515–521.
3. Roos-Hesselink JW, Ruys TP, Stein JI, Thilén U, Webb GD, Niwa K, Kaemmerer H, Baumgartner H, Budts W, Maggioni
AP, Tavazzi L, Taha N, Johnson MR, Hall R; ROPAC Investigators. Outcome of pregnancy in patients with structural or
ischaemicheartdisease:resultsofaregistryoftheEuropeanSocietyofCardiology.EurHeartJ.2013;34:657–665.
4. Presbitero P, Somerville J, Stone S, Aruta E, Spiegelhalter D, Rabajoli F. Pregnancy in cyanotic congenital heart
disease.Outcomeofmotherandfetus.Circulation.1994;89:2673–2676.
5. Gelson E, Curry R, Gatzoulis MA, Swan L, Lupton M, Steer P, Johnson M. Effect of maternal heart disease on fetal
growth.ObstetGynecol.2011;117:886–891.
References

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  • 1. Challenges in Management of Advanced Heart Disease “ YTP UPDATE 2020” Author - Dr Indranil Dutta MBBS, MS(OBG), FIAOG, FAGE, FIAMS Dip in Advanced Gynae Endoscopy(Germany) Associate Prof, IQCMC, Durgapur President KOGS Dr. Neharika M Bora MD(obgyn), DRM Germany Rainbow IVF, Agra BROUGHT TO YOU BY YTP CHAIRPERSON Cardiovascular disease is a leading cause of maternal death. The normal cardiovascular hemodynamic adaptations to pregnancy are remarkable, but tolerated without difficulty in the majority of women. However, in women with cardiovascular dysfunction, these adaptations may precipitate cardiovascular decompensation. Risk stratification of pregnancy risk should preferably take place before conception. Management of these women requires multidisciplinary involvement of all key areas, including cardiology, nursing, maternal/fetal medicine and obstetric anesthesia. For higher- risklesions,pregnancyshouldbemanagedincenterswithexpertiseinthisfield. There are numerous contributors of this rising risk, including advancing maternal age, pre-existing cardiovascular risk factors, the rise in multifetal pregnancies and survival to fertility age among childhood cancer survivors and women with congenital heart disease. Unlike most cardiovascular conditions, there are no large randomized controlledtrialstoguidedecision-making,andguidelinesarebasedprincipallyonexpertconsensus. It is increasingly likely that a cardiologist will be called upon to manage these women, so it is incumbent upon them to understand the basic cardiovascular hemodynamics of pregnancy and fundamental risk stratification and management oftheseconditions. In the United States, disease and dysfunction of the heart and vascular system as “cardiovascular disease” is now the leading cause of death in pregnant women and women in the postpartum period accounting for 4.23 deaths per 100,000 live births, a rate almost twice that of the United Kingdom. The most recent data indicate that cardiovascular 1 diseasesconstitute 26.5%ofU.S.pregnancy-relateddeaths . CHD was the most common form of heart disease complicating pregnancy in the Western world (accounting for 74% of cases in the Canadian Cardiac Disease in Pregnancy [CARPREG] registry and 66% of cases in the European Registry on Pregnancy and Cardiac Disease [ROPAC] registry), whereas in less developed countries, rheumatic heart 2,3 diseaseplaysalargerrole The normal cardiovascular hemodynamic adaptations to pregnancy are remarkable but tolerated without difficulty in the majority of women. In women with cardiovascular dysfunction, however, these adaptations may precipitate cardiovascular decompensation. Hemodynamic changes begin in the first trimester, with a 30–50 % rise in cardiac output, driven by an increase in stroke volume and, to a lesser extent, heart rate. Systemic vascular resistance falls as a result of endogenous vasodilators, as well as flow into the low-resistance uteroplacental unit. During labor and delivery, cardiac output is further increased because of auto transfusion from the contracting uterus as well as an increase in heart rate becauseofmaternalpainduring labor. Hemodynamics of Pregnancy The care of pregnant women with heart disease involves several stakeholders with different perspectives but common goals: pre-conceptional counselling is important followed by delivery of a healthy baby and a mother free of cardiac complications. This team should include an obstetric anesthesiologist, maternal fetal medicine specialist, nursing staffandacardiologistwithexpertiseinthemanagement ofpregnantwomen Multidisciplinary Care
  • 2. Women with mechanical heart valves have an elevated risk of complications during pregnancy and only a 58 % chance of a having an uncomplicated pregnancy with a live birth. The use of anticoagulants during pregnancy is challengingandinfluencedbyahypercoagulablestateandchangesinthevolumeofdistribution andcreatinine clearance Anticoagulation for Mechanical Heart Valves Fortunately, pregnancy-associated acute MI (PAMI) is uncommon, although its incidence is increasing and inhospital mortality remains high at 4.5 %The management of PAMI is individualized. However, in the presence of hemodynamic instability, heart failure or refractory chest pain, angiography is warranted. As a high proportion of PAMI cases are caused by SCAD, in which coronary angiography can propagate dissection, methods to reduce coronary manipulation are recommended such as avoiding deep catheter engagement of the coronary ostia and gentle contrast injections. Coronary CT may have an emerging role in the population of patients who are at a lower risk with suspected CAD, and provides additionaldataonthevesselwallsuchaspresenceofplaque,intramuralhematomaordissection. Acute MI During Pregnancy Despite the increased hemodynamic burden of labor and delivery, including a further increase in heart rate, stroke volume and cardiac output, vaginal delivery remains the optimal method of delivery. Cesarean section increases the risk of maternal infection, leads to great hemodynamic shifts and blood loss, brings a risk of surgical injury and raises the likelihood of thrombotic events. Although there is no consensus over absolute contraindications for vaginal delivery, cesarean section can be considered for some women with certain cardiac conditions, including preterm labor in those receiving full oral anticoagulation, Marfan's syndrome with an aorta over 45 mm, acute or chronic aortic dissection, and intractableheartfailure.Generally,cesareansectionisreservedforobstetricalindications Mode of Delivery Fetaloutcomesarealsoimpaired in somemotherswith CHD.Higher chancesofIUGRwith LowBurth Weight babies.More incidences of preterm labour, increased risk of miscarriage or intrauterine demise, and increased perinatal mortality. Decreased maternal cardiac output and maternal cyanosis are significantly associated with an increase in fetal 4,5 complications . Impact on Fetal Outcomes Cardiovascular disease is a leading cause of maternal death. Cardiovascular training programs are increasingly providing education on the management of cardiovascular disorders during pregnancy and it is increasingly likely that cardiologists willbecalledupontomanagethesewomen. Conclusion 1. ACOG Practice Bulletin No. 212: Pregnancy and Heart Disease, Author Information, Obstetrics & Gynecology: May 2019-Volume133-Issue5-pe320-e356,doi:10.1097/AOG.0000000000003243 2. Siu S, Sermer M, Colman J, Alvarez N, Mercier L, Morton B, Kells C, Bergin L, Kiess M, Marcotte F, Taylor D, Gordon E, Spears J, Tam J, Amankwah K, Smallhorn J, Farine D, Sorensen S. Prospective multicenter of pregnancy outcomes in womenwithheartdisease.Circulation.2001;104:515–521. 3. Roos-Hesselink JW, Ruys TP, Stein JI, Thilén U, Webb GD, Niwa K, Kaemmerer H, Baumgartner H, Budts W, Maggioni AP, Tavazzi L, Taha N, Johnson MR, Hall R; ROPAC Investigators. Outcome of pregnancy in patients with structural or ischaemicheartdisease:resultsofaregistryoftheEuropeanSocietyofCardiology.EurHeartJ.2013;34:657–665. 4. Presbitero P, Somerville J, Stone S, Aruta E, Spiegelhalter D, Rabajoli F. Pregnancy in cyanotic congenital heart disease.Outcomeofmotherandfetus.Circulation.1994;89:2673–2676. 5. Gelson E, Curry R, Gatzoulis MA, Swan L, Lupton M, Steer P, Johnson M. Effect of maternal heart disease on fetal growth.ObstetGynecol.2011;117:886–891. References